Esophageal Liposarcoma: A Case Report and Review of the Literature

Abstract

Liposarcomas are extremely rare occurrences in the esophagus. Here, we present an unusual case of esophageal liposarcoma that contributed to a long history of dysphagia before a definitive diagnosis was reached. The case is that of a 61-year-old woman who complained of dysphagia and foreign body sensation in her throat and was found to have a large filling defect within the cervical esophagus on barium esophagogram. She underwent endoscopic resection of the mass and was diagnosed with a five-centimeter long, well-differentiated esophageal liposarcoma, confirmed with fluorescence in situ hybridization for MDM2 gene locus amplification. Subsequent laser ablation of the tumor bed was conducted with no recurrences noted to date. Proper histologic identification, alongside adjunctive cytogenetic and molecular diagnostics, followed by definitive surgical resection and extended follow-up, are emphasized as critical in optimizing outcomes for this disease. A review of the existing English-language medical literature relating to esophageal liposarcoma was performed and summarized.

Dedifferentiated Mediastinal Liposarcoma: A Case Report

“…Liposarcomas are the most common type of soft tissue sarcomas characterized by adipocytic differentiation and mesenchymal origin. Liposarcomas mainly arise from the soft tissues of the extremities and the retroperitoneal region [1]. On the other hand, mediastinal liposarcoma constitutes a rare entity, accounting for fewer than 1% of mediastinal tumors, and approximately 2% of liposarcomas [2].…”