Esophageal motor abnormalities in gastroesophageal reflux and the effects of fundoplication

Gill, Richard C.; Bowes, Kenneth L.; Murphy, P.D.; Kingma, Y.J.

doi:10.1016/0016-5085(86)90570-6

Cited by 97 publications

(44 citation statements)

References 25 publications

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“…Our findings are similar to those described by other authors [7,[9][10][11][12][13][14][15], and suggest that the minimal or slight inflammatory changes in oesophageal mucosa cause a state of irritability with a tendency towards spastic con tractions of the oesophageal musculature, whereas severe inflammation leads to a decrease and, in some cases, a total loss of muscle contractability. These alterations lead to a poor clearance of refluxed material, which increases the duration of acid exposure of oesophageal mucosa, as was confirmed in our pH-metric study.…”

Section: Discussionsupporting

confidence: 92%

“…However, there is less information available on the role played by oesophageal motor alterations in the pathogenesis of this disease and even controversy on the subject. Thus, while some authors [7,[9][10][11][12][13][14][15] claim that peristaltic dysfunction is secondary to gastro-oesophageal reflux, others [8,[16][17][18][19] believe that it is a primary motor disorder forming part of a multifactorial aetiology.…”

Section: Introductionmentioning

confidence: 99%

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Correlation between Endoscopic and pH-Metric Findings and Motor Oesophageal Alterations in Reflux Oesophagitis

P¹,

Haro²,

Ortiz³

et al. 1991

Dig Surg

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This study analyses the resting pressure of the lower oesophageal sphincter and the motor function of the oesophageal body in 53 patients with gastro-oesophageal reflux disease, diagnosed through clinical data, endoscopy, biopsy and, in some cases, long-term monitoring of intra-oesophageal pH. The patients were divided into two groups: mild oesophagitis (n = 25) and severe oesophagitis (n = 28), and the manometric and pH-metric results obtained were compared with those of a control group comprising 20 healthy volunteers. This analysis concludes that resting sphincter pressure is inversely related to the severity of oesophagitis and acid reflux rate, and that there is a motor alteration in the oesophageal body, with a motor uncoordination model predominating in the mild oesophagitis group, and a hypokinetic motor model in the severe oesophagitis group. Both types of peristaltic dysfunction contribute to the increase in exposure of oesophageal mucosa to the material refluxed, thus aggravating the oesophagitis.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Correlation between Endoscopic and pH-Metric Findings and Motor Oesophageal Alterations in Reflux Oesophagitis

P¹,

Haro²,

Ortiz³

et al. 1991

Dig Surg

View full text Add to dashboard Cite

show abstract

“…Gill et al have reported shorter durations of contraction in this condition (Gill et al,1986). On the other hand, Singh et al have found a longer durations of contraction in patients with GERD compared with the controls (Singh et al,1992).…”

Section: Wwwintechopencommentioning

confidence: 86%

Esophageal Motility and Gastroesophageal Reflux

Grande¹,

Villa²,

Cadeddu³

2012

Gastroesophageal Reflux Disease

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“…In patients with reflux, a variety of abnormalities of peristaltic function may be noted. Current evidence suggests that a subset of patients with reflux disease have abnormal esophageal peristalsis with either a decreased incidence of the complete peristaltic sequence after swallowing, hypotensive peristaltic waves, or impaired response to esophageal distention [58,61]. However, from the clinical perspective, the question is whether these manometric findings in a patient can be predictive of significant gastroesophageal reflux disease?…”

Section: Gastroesophageal Reflux Diseasementioning

confidence: 99%

Clinical Value of Esophageal Motility Testing

DiMarino

Allen²,

Lynn³

et al. 1998

Dig Dis

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Esophageal motility testing is the method of choice in evaluating esophageal motor disorders. Some physicians, however, question the clinical utility of esophageal motility testing, since the results are often normal in symptomatic patients. The clinical utility of esophageal motility testing is reviewed for patients with a complaint of noncardiac chest pain, dysphagia or symptoms of gastroesophageal reflux disease. Esophageal motility testing is particularly useful for evaluating patients with dysphagia, but less so for gastroesophageal reflux disease patients, and has little clinical utility in patients with noncardiac chest pain.

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Esophageal motor abnormalities in gastroesophageal reflux and the effects of fundoplication

Cited by 97 publications

References 25 publications

Correlation between Endoscopic and pH-Metric Findings and Motor Oesophageal Alterations in Reflux Oesophagitis

Correlation between Endoscopic and pH-Metric Findings and Motor Oesophageal Alterations in Reflux Oesophagitis

Esophageal Motility and Gastroesophageal Reflux

Clinical Value of Esophageal Motility Testing

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