Esophageal motor disturbances in progressive systemic sclerosis*

Henry, Maria Aparecida Coelho Arruda; Harbermann, M. C.; Rocha, Oswaldo Melo da

doi:10.1046/j.1442-2050.1999.00005.x

Cited by 18 publications

(14 citation statements)

References 4 publications

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“…9,10 Our study, however, shows that peristalsis is preserved in all patients with CTD when no other organs other than the esophagus are involved. Specifically, we demonstrated that in most patients with cutaneous and gastrointestinal manifestations only, the motility profile was similar to that of patients with GERD but without CTD.…”

Section: Connective Tissue Disorders and Esophageal Motilitymentioning

confidence: 60%

Gastroesophageal Reflux Disease and Connective Tissue Disorders: Pathophysiology and Implications for Treatment

Patti

Gasper

Fisichella

et al. 2008

Journal of Gastrointestinal Surgery

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These data show that esophageal motor function is preserved in most patients with CTD, so that they should be offered antireflux surgery early in the course of their disease to prevent esophageal and respiratory complications. In patients with ESLD in whom peristalsis is absent, a partial rather than a total fundoplication should be performed, as it allows control of reflux symptoms while avoiding postoperative dysphagia.

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Section: Connective Tissue Disorders and Esophageal Motilitymentioning

confidence: 60%

Gastroesophageal Reflux Disease and Connective Tissue Disorders: Pathophysiology and Implications for Treatment

Patti

Gasper

Fisichella

et al. 2008

Journal of Gastrointestinal Surgery

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“…Although the picture appears myogenic, it follows a course with degeneration in Auerbach's plexus. Esophageal emptying is delayed due to ineffective peristaltic movements; lower esophageal sphincter pressure falls and gastroesophageal reflux develops [7]. Related to this, candida esophagitis, erosive esophagitis, Barrett's esophagus, diverticles, fibrous stricture, and malignancy may develop as complications.…”

Section: Discussionmentioning

confidence: 99%

“…Stricture and findings compatible with esophagitis may be determined in endoscopic examination. Manometrically, low-amplitude peristaltic contractions and a reduction in lower sphincter pressure are typical [6, 7]. Pyrosis, dysphagia, acid regurgitation, aspiration, chest pain, nausea, and vomiting are complications frequently encountered with esophageal involvement of scleroderma.…”

Section: Discussionmentioning

confidence: 99%

Esophagectomy in Scleroderma: Report of a Case

Yekeler

Gürsan²

2008

Case Rep Gastroenterol

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Scleroderma is a generalized autoimmune disease with variable involvement of the skin and major organs (esophagus, lung, heart and kidney). Scleroderma is essentially a skin disease that frequently involves the digestive system. In scleroderma, the esophagus is the most frequently affected organ of the digestive system, and esophageal dysmotility, reflux and stricture may be observed in the advanced stage. Balloon dilatation and bougienage are generally sufficient in patients developing stricture, and the number of cases in whom resection is performed is very low. In a 20-year-old patient with difficulty in taking even liquid foods, tests revealed sclerodermal involvement of the distal end of the esophagus and stricture. Esophageal resection and gastric replacement were performed. Such systemic diseases as scleroderma, although rare, must be considered in the differential diagnosis of nonmalignant dysphagia, and resection must be borne in mind as a surgical option in cases of advanced stricture.

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“…Esophageal manometry was performed using the usual technique of our laboratory (7) which included an 8-channel probe, physiographic process and continuous infusion device. Through the analysis of the graphic records the following parameters were evaluated: lower and upper sphincter resting pressure of the esophagus (LES, UES) and its peristalsis.…”

Section: • Esophageal Manometrymentioning

confidence: 99%

Gastroesophageal reflux disease and vocal disturbances

Henry

Martins

Lerco

et al. 2011

Arq. Gastroenterol.

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CONTEXT: Gastroesophageal reflux disease is a chronic disease in which gastroduodenal contents reflux into the esophagus. The clinical picture of gastroesophageal reflux disease is usually composed by heartburn and regurgitation (typical manifestations). Atypical manifestations (vocal disturbances and asthma) may also be complaint. OBJECTIVE: To analyse the clinical, endoscopic, manometric and pHmetric aspects of patients suffering from gastroesophageal reflux disease associated with vocal disturbances. METHODS: Fifty patients with gastroesophageal reflux disease were studied, including 25 with vocal disturbances (group 1 - G1) and 25 without these symptoms (group 2 - G2). All patients were submitted to endoscopy, manometry and esophageal pHmetry (2 probes). The group 1 patients were submitted to videolaryngoscopy. RESULTS: Endoscopic findings: non-erosive reflux disease was observed in 95% of G1 patients and 88% of G2. Videolaryngoscopy: vocal fold congestion, asymmetry, nodules and polyps were observed in G1 patients. Manometric findings: pressure in the lower esophageal sphincter (mm Hg): 11.6 ± 5.2 in G1 and 14.0 ± 6.2 in G2 (P = 0.14); pressure in the upper esophageal sphincter (mm Hg): 58.4 ± 15.9 in G1 and 69.5 ± 30.7 in the controls. pHmetric findings: De Meester index: 34.0 ± 20.9 in G1 and 15.4 ± 9.4 in G2 (P<0.001); number of reflux episodes in distal probe: 43.0 ± 20.4 in G1 and 26.4 ± 17.2 in G2 (P = 0.003); percentage of time with esophageal pH value lower than 4 units (distal sensor): 9.0% ± 6.4% in G1 and 3.4% ± 2.1% in G2 (P<0.001); number of reflux episodes in proximal probe: 7.5 ± 10.9 in G1 and 5.3 ± 5.7 in G2 (P = 0.38); percentage of time with esophageal pH values lower than 4 units (Proximal probe): 1.2 ± 2.7 in G1 and 0.5 ± 0.7 in G2 (P = 0.21). CONCLUSIONS: 1) The clinical, endoscopic, and manometric findings observed in patients with vocal disturbance do not differ from those without these symptoms; 2) gastroesophageal reflux intensity is higher in patients with vocal disturbance; 3) patients without vocal disturbance can also present reflux episodes in the proximal probe.

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Esophageal motor disturbances in progressive systemic sclerosis*

Cited by 18 publications

References 4 publications

Gastroesophageal Reflux Disease and Connective Tissue Disorders: Pathophysiology and Implications for Treatment

Gastroesophageal Reflux Disease and Connective Tissue Disorders: Pathophysiology and Implications for Treatment

Esophagectomy in Scleroderma: Report of a Case

Gastroesophageal reflux disease and vocal disturbances

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