Esophageal Sphincter Device for Gastroesophageal Reflux Disease

doi:10.1056/nejmc1303656

Cited by 16 publications

(7 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Zur Beurteilung der Methode stehen zahlreiche prospektive und retrospektive Kohortenstudien, eine prospektiv randomisierte Studie mit dem Vergleich zu einer Doppeldosis Protonenpumpeninhibitoren (PPI) wie auch einige nicht randomisierte Studien im Vergleich zur laparoskopischen Fundoplikation zur Verfügung [9 -13]. Zwei größere Metaanalysen fassen die Ergebnisse zusammen [14,15].…”

Section: Magnetische Sphinkteraugmentation (Msa)unclassified

Alternative operative Verfahren zur Behandlung der gastroösophagealen Refluxerkrankung

Schoppmann

2021

Zentralbl Chir

View full text Add to dashboard Cite

ZusammenfassungDas Versagen der medikamentösen Therapie bei mehr als 30% der Patienten mit gastroösophagealer Refluxerkrankung (GERD) wie auch zunehmende Bedenken bez. einer säurehemmenden Dauertherapie haben zu einer neuen Fokussierung auf chirurgische Antirefluxtherapien geführt. Unter den Sphinkteraugmentationsverfahren haben die beiden laparoskopischen Verfahren, die magnetische (LINX) und die elektrische (EndoStim), eine breitere Anwendung gefunden. Die magnetische Sphinkteraugmentation stellte eine sehr sichere (Komplikationsrate 0,1% und Reoperationsrate 3,4%) Methode dar, die sowohl zu signifikanten Verbesserungen der subjektiven (GERD-HRQL-Verbesserung 19,9 auf 4,1; p = 0,001) als auch objektiven GERD-Erfolgsparameter (79% PPI-Freiheit und 89% Normalisierung der Säureexposition im distalen Ösophagus) führt. Die elektrische Sphinkteraugmentation hat erste vielversprechende Kurzzeitergebnisse in geringen Patientenanzahlen gezeigt (92% subjektive Beschwerdeverbesserung). Ein Vergleich zum operativen Goldstandard der laparoskopischen Fundoplikation ist bei beiden Methoden ausständig. Alternative, laparoskopische Antirefluxmethoden stellen eine potenzielle Alternative zur laparoskopischen Fundoplikation dar.

show abstract

Section: Magnetische Sphinkteraugmentation (Msa)unclassified

Alternative operative Verfahren zur Behandlung der gastroösophagealen Refluxerkrankung

Schoppmann

2021

Zentralbl Chir

View full text Add to dashboard Cite

show abstract

“…After one year follow-up, patients were reported to be off PPIs in 25% of cases. EsophyX offers advantages over surgery [14][15][16][17], in particular the absence of incision and thus a faster remission, as well as fewer complications in the short and long term compared to the undesirable side effects associated with laparoscopic anti-reflux procedure compromising the results in some patients. Currently published literature suggests that incidence of persistent side effects after TIF is low [4][5][6].…”

Section: Discussionmentioning

confidence: 99%

Evolution and Outcome of Eight Patients Undergoing Treatment of Gastroesophageal Disease by Esophyx

Abboud¹,

Khalek²

2017

J Gastrointest Dig Syst

View full text Add to dashboard Cite

Background: Gastroesophageal reflux disease (GERD) is arguably the most common disease encountered by the gastroenterologist. It is mainly caused by defects in the lower esophageal sphincter (LES) that induces spontaneous transient LES relaxations (tLESRs). This is a chronic condition with typical and atypical, sometimes troublesome manifestations requiring long term treatment. Anti-reflux surgery is an alternative option. The TIF (transoral incisionless fundoplication) procedure by offering some advantages over surgery could be recommended for patients whose symptoms recur upon discontinuation of the medications. This study intended to assess the safety and efficacy of TIF for treating GERD.

show abstract

“…The magnetic union between each of the beads allows the passage of the swallowed bolus but inhibits the reflux of stomach contents into the esophagus 5 ( Figure 1 ). Although several studies have demonstrated the safety and efficacy of the device 3 - 5 , 7 , 10 - 14 , 16 , 19 , 20 , 23 , 25 , 26 , 29 , 32 - 34 , 40 , 41 , 43 , 45 , 46 , 48 - 50 , 52 , 55 , large series and randomized trials supporting its use are still lacking.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Sphincter Augmentation Device for Gastroesophageal Reflux Disease: Effective, but Postoperative Dysphagia and Risk of Erosion Should Not Be Underestimated. A Systematic Review and Meta-Analysis

Valinoti,

Angeramo,

Dreifuss

et al. 2023

ABCD, arq. bras. cir. dig.

View full text Add to dashboard Cite

BACKGROUND: Magnetic ring (MSA) implantation in the esophagus is an alternative surgical procedure to fundoplication for the treatment of gastroesophageal reflux disease. AIMS: The aim of this study was to analyse the effectiveness and safety of magnetic sphincter augmentation (MSA) in patients with gastroesophageal reflux disease (GERD). METHODS: A systematic literature review of articles on MSA was performed using the Medical Literature Analysis and Retrieval System Online (Medline) database between 2008 and 2021, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A random-effect model was used to generate a pooled proportion with 95% confidence interval (CI) across all studies. RESULTS: A total of 22 studies comprising 4,663 patients with MSA were analysed. Mean follow-up was 27.3 (7–108) months. The weighted pooled proportion of symptom improvement and patient satisfaction were 93% (95%CI 83–98%) and 85% (95%CI 78–90%), respectively. The mean DeMeester score (pre-MSA: 34.6 vs. post-MSA: 8.9, p=0.03) and GERD-HRQL score (pre-MSA: 25.8 vs. post-MSA: 4.4, p<0.0001) improved significantly after MSA. The proportion of patients taking proton pump inhibitor (PPIs) decreased from 92.8 to 12.4% (p<0.0001). The weighted pooled proportions of dysphagia, endoscopic dilatation and gas-related symptoms were 18, 13, and 3%, respectively. Esophageal erosion occurred in 1% of patients, but its risk significantly increased for every year of MSA use (odds ratio — OR 1.40, 95%CI 1.11–1.77, p=0.004). Device removal was needed in 4% of patients. CONCLUSIONS: Although MSA is a very effective treatment modality for GERD, postoperative dysphagia is common and the risk of esophageal erosion increases over time. Further studies are needed to determine the long-term safety of MSA placement in patients with GERD.

show abstract

Esophageal Sphincter Device for Gastroesophageal Reflux Disease

Cited by 16 publications

References 23 publications

Alternative operative Verfahren zur Behandlung der gastroösophagealen Refluxerkrankung

Alternative operative Verfahren zur Behandlung der gastroösophagealen Refluxerkrankung

Evolution and Outcome of Eight Patients Undergoing Treatment of Gastroesophageal Disease by Esophyx

Magnetic Sphincter Augmentation Device for Gastroesophageal Reflux Disease: Effective, but Postoperative Dysphagia and Risk of Erosion Should Not Be Underestimated. A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About