Esophageal squamous cell carcinoma: Integrated bioinformatics analysis for differential gene expression with identification of hub genes and lncRNA

Hasib, F.M. Yasir

doi:10.1016/j.bbrep.2022.101262

Cited by 2 publications

(4 citation statements)

References 41 publications

(29 reference statements)

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“…The expression of Hymai is partially connected to the expression of Plagl1 since Hymai is also transcribed upon the regulation of P1 promoter. Altered expression of both Plagl1 and Hymai were described as indicative of disease condition such as TNDM and tumours [ 46 , 47 ]. In our experiments, altered expression pattern of both Hymai and Plagl1it was recorded in the Rybp null mutant cardiac cultures ( figure 1 g , h ) suggesting that the lack of RYBP influences their expression and this might be related to disease conditions as well .…”

Section: Discussionmentioning

confidence: 99%

Polycomb protein RYBP activates transcription factor Plagl1 during in vitro cardiac differentiation of mouse embryonic stem cells

2023

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RING1 and YY1 binding protein (RYBP) is primarily known to function as a repressor being a core component of the non-canonical polycomb repressive complexes 1 (ncPRC1s). However, several ncPRC1-independent functions of RYBP have also been described. We previously reported that RYBP is essential for mouse embryonic development and that Rybp null mutant embryonic stem cells cannot form contractile cardiomyocytes (CMCs) in vitro . We also showed that PLAGL1, a cardiac transcription factor, which is often mutated in congenital heart diseases (CHDs), is not expressed in Rybp -null mutant CMCs. However, the underlying mechanism of how RYBP regulates Plagl1 expression was not revealed. Here, we demonstrate that RYBP cooperated with NKX2-5 to transcriptionally activate the P1 and P3 promoters of the Plagl1 gene and that this activation is ncPRC1-independent. We also show that two non-coding RNAs residing in the Plagl1 locus can also regulate the Plagl1 promoters. Finally, PLAGL1 was able to activate Tnnt2 , a gene important for contractility of CMCs in transfected HEK293 cells. Our study shows that the activation of Plagl1 by RYBP is important for sarcomere development and contractility, and suggests that RYBP, via its regulatory functions, may contribute to the development of CHDs.

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Section: Discussionmentioning

confidence: 99%

Polycomb protein RYBP activates transcription factor Plagl1 during in vitro cardiac differentiation of mouse embryonic stem cells

2023

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“…Immunohistochemical studies have shown that ESCC tumors larger than 6.5 cm show higher CXCL1 expression than in the sample of ESCC tumors smaller than 6.5 cm. CXCL1 expression is also higher in ESCC stages II-IV than in stage I, showing that the expression of CXCL1 increases with tumor growth and development [57]. At the same time, CXCL1 expression in ESCC is not associated with the depth of invasion or lymph node metastasis [56].…”

Section: Esophageal Cancermentioning

confidence: 98%

“…CXCL1 expression is elevated in ESCC tumors relative to healthy tissue [54,55], along with an elevated level of CXCL1 in the blood compared to healthy individuals [56]. Bioinformatic analyses have identified CXCL1 as one of the hub genes in ESCC [55,57]. A high level of CXCL1 in the blood is associated with a low risk of ESCC [58], which may reflect either antitumor mechanisms involving CXCL1 in the early stages of ESCC development or a protective effect.…”

Section: Esophageal Cancermentioning

confidence: 99%

“…At the same time, CXCL1 expression in ESCC is not associated with the depth of invasion or lymph node metastasis [56]. Higher CXCL1 expression in CAF in ESCC tumors may be associated with a poorer prognosis (Table 2) [56], and higher CXCL1 expression in tumors may be associated with a better prognosis for ESCC patients [57]. However, there are also studies that show no association between CXCL1 expression in the tumor and prognosis for esophageal cancer patients [65].…”

Section: Esophageal Cancermentioning

confidence: 99%

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The Clinical Significance and Role of CXCL1 Chemokine in Gastrointestinal Cancers

Korbecki

Bosiacki

Barczak

et al. 2023

Cells

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One area of cancer research is the interaction between cancer cells and immune cells, in which chemokines play a vital role. Despite this, a comprehensive summary of the involvement of C-X-C motif ligand 1 (CXCL1) chemokine (also known as growth-regulated gene-α (GRO-α), melanoma growth-stimulatory activity (MGSA)) in cancer processes is lacking. To address this gap, this review provides a detailed analysis of CXCL1’s role in gastrointestinal cancers, including head and neck cancer, esophageal cancer, gastric cancer, liver cancer (hepatocellular carcinoma (HCC)), cholangiocarcinoma, pancreatic cancer (pancreatic ductal adenocarcinoma), and colorectal cancer (colon cancer and rectal cancer). This paper presents the impact of CXCL1 on various molecular cancer processes, such as cancer cell proliferation, migration, and invasion, lymph node metastasis, angiogenesis, recruitment to the tumor microenvironment, and its effect on immune system cells, such as tumor-associated neutrophils (TAN), regulatory T (Treg) cells, myeloid-derived suppressor cells (MDSCs), and macrophages. Furthermore, this review discusses the association of CXCL1 with clinical aspects of gastrointestinal cancers, including its correlation with tumor size, cancer grade, tumor–node–metastasis (TNM) stage, and patient prognosis. This paper concludes by exploring CXCL1’s potential as a therapeutic target in anticancer therapy.

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Esophageal squamous cell carcinoma: Integrated bioinformatics analysis for differential gene expression with identification of hub genes and lncRNA

Cited by 2 publications

References 41 publications

Polycomb protein RYBP activates transcription factor Plagl1 during in vitro cardiac differentiation of mouse embryonic stem cells

Polycomb protein RYBP activates transcription factor Plagl1 during in vitro cardiac differentiation of mouse embryonic stem cells

The Clinical Significance and Role of CXCL1 Chemokine in Gastrointestinal Cancers

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