“…We found two reports of esophageal squamous papillomatosis with malignant degeneration, one of which had concomitant HPV infection. 4,5 Esophageal squamous papillomatosis is a rare lesion that is usually found incidentally on upper endoscopy or at autopsy. The reported incidence of this lesion at endoscopy varies widely, from 0.077% to 0.35%.…”
Section: Discussionmentioning
confidence: 99%
“…22 We found two reported cases of ESCC in association with esophageal papillomatosis. 4,5 Several etiologies have been proposed for ESP. The high incidence of papillomas in the lower esophagus raises suspicion that chronic irritation due to esophageal reflux could be a cause.…”
Section: Discussionmentioning
confidence: 99%
“…18,20,25 Conversely, the literature contains one report of adenocarcinoma and two reports of SCC in ESP treated with esophagectomy in 'low risk' areas. 4,5,22 We present a case of squamous cell carcinoma in situ within a large squamous papilloma of the esophagus, diagnosed after esophagectomy. To our knowledge this is the third such reported case in a 'low risk' area.…”
We present a case of esophageal papillomatosis with underlying squamous cell carcinoma in situ. An esophageal lesion resected from a 74-year-old woman demonstrated histological findings characteristic of squamous cell papilloma (fibrovascular core and numerous finger-like projections covered with hyperplastic squamous epithelium) and severe dysplasia characteristic of squamous cell carcinoma. The relation of squamous papilloma and squamous cell carcinoma is discussed. It is suggested that esophageal squamous cell papilloma is a premalignant lesion.
“…We found two reports of esophageal squamous papillomatosis with malignant degeneration, one of which had concomitant HPV infection. 4,5 Esophageal squamous papillomatosis is a rare lesion that is usually found incidentally on upper endoscopy or at autopsy. The reported incidence of this lesion at endoscopy varies widely, from 0.077% to 0.35%.…”
Section: Discussionmentioning
confidence: 99%
“…22 We found two reported cases of ESCC in association with esophageal papillomatosis. 4,5 Several etiologies have been proposed for ESP. The high incidence of papillomas in the lower esophagus raises suspicion that chronic irritation due to esophageal reflux could be a cause.…”
Section: Discussionmentioning
confidence: 99%
“…18,20,25 Conversely, the literature contains one report of adenocarcinoma and two reports of SCC in ESP treated with esophagectomy in 'low risk' areas. 4,5,22 We present a case of squamous cell carcinoma in situ within a large squamous papilloma of the esophagus, diagnosed after esophagectomy. To our knowledge this is the third such reported case in a 'low risk' area.…”
We present a case of esophageal papillomatosis with underlying squamous cell carcinoma in situ. An esophageal lesion resected from a 74-year-old woman demonstrated histological findings characteristic of squamous cell papilloma (fibrovascular core and numerous finger-like projections covered with hyperplastic squamous epithelium) and severe dysplasia characteristic of squamous cell carcinoma. The relation of squamous papilloma and squamous cell carcinoma is discussed. It is suggested that esophageal squamous cell papilloma is a premalignant lesion.
“…It is noteworthy to point out that all lesions of the Goltz syndrome with EPS, involved the distal esophagus (Table 2 ). Special endoscopy technologies were also used to detect and distinguish EPS lesions, such as narrow band imaging (NBI) with magnifying endoscopy [ 45 , 47 , 50 ], and Lugol’s solution staining [ 14 , 51 ] and endoscopic ultrasonography [ 39 , 52 , 53 ]. Fig.…”
If esophageal papilloma (EP) is a rare condition, esophageal papillomatosis (EPS) is a distinct rarity. To date, only 53 well documented cases have been described in English literature. However, the number of reports on EPS significantly increased to over 40 cases during the past 20 years. Perhaps, this is due to the broad use of endoscopy and related research achievements. Most of the cases are individual and it seems that there are no associations between them. And up to now no guidelines can be followed. To further understand this exceedingly rare disease, we had a comprehensive review of the epidemiology, etiology, clinical manifestations, pathogenesis, treatment, and clinical course of EPS.
“…Özofagus skuamoz hücre-li papilloma benign bir lezyondur, uzun süreli takiplerde malignitenin efllik etmedi¤i bildirilmifltir. Nadiren de skuamoz hücreli Ca ile komplike olabilir (26)(27)(28)(29).…”
Özofagusun benign bir lezyonu olan skuamoz hücreli papilloman›n etyolojisi net de¤ilse de gastroözofageal reflü hastal›¤›na ba¤l› özofajit veya Barret lezyonuna ba¤l› kronik irritasyon ve human papilloma virus infeksiyonu ile iliflkilendirilmifltir. Özofagus skuamoz hücreli papillomas› s›kl›kla soliter ve distal yerleflimlidir. Bu olgumuzda tüm özofagusu tutan çok say›da skuamoz hücreli papillomalar vard›.
Anahtar Kelimeler: Skuamoz hücreli papillom, özofagus, HPVThe pathogenesis of esophageal squamous papilloma is not fully open, but it is associated with esophagitis due to gastroesophageal reflux disease or Barrett's lesions and HPV infection. Esophageal squamous cell papillomas are usually located solitary and the distal esophagus. In this case multiple squamous cell papillomas of the esophagus is reported.Key words: Esophagus, squamous cell papilloma, HPV
G‹R‹fiÖzofagus skuamoz hücreli papillomas› nadir görülen, benign, skuamoz epitelyal bir tümördür. Genellikle endoskopik incelemede rastlant›sal olarak görülür (1, 2). Özofagus skuamoz hücreli papilloma s›kl›¤› otopsi ve endoskopi serilerinde %0.01 %0.45 oranlar›nda bildirilmifltir (3-6).Özofagus skuamoz hücreli papilloman›n etyolojisinde 2 faktörün rol ald›¤› düflünülmektedir. Birincisi minor travma, alkol, tütün, kronik besin "impaction", gastroözofageal cerrahi öyküsü ve gastroözofageal reflü hastal›¤› (GERD) gibi nedenler ile kimyasal veya mekanik irritasyona cevap olarak mukozada hiper-rejeneratif yan›t oluflmas›d›r. Özofagus skuamoz hücreli papilloman›n alt özofagusta daha s›k olmas›, bu böl-genin GERD'den s›k etkilenmesi nedeniyle mukozal irritasyon teorisini desteklemektedir (4).Di¤er teori ise human papilloma virus (HPV) infeksiyonunun etyolojide rol ald›¤› yolundad›r. Syrjanen ve arkadafllar› HPV'nin etyolojide rol ald›¤›n› göstermifllerdir. Ancak HPV'nin etyolojideki rolü hala tart›flmal›d›r (5).
OLGU SUNUMUK›rk sekiz yafl›nda kad›n hasta klini¤imize yutma güçlü¤ü flikayeti ile baflvurdu. fiikayeti son bir kaç ayd›r art›fl göstermiflti. Hastan›n kilo kayb›, bulant›, kusma flikayetleri mevcut de¤ildi. Sigara ve alkol kullanm›yordu. Hikayesinde radyoterapi öykü-sü veya yak›n akrabalara ait malign hastal›k öyküsü yoktu. Hastan›n tüm bat›n ultrasonografisinde patolojik bulgu saptanmad›. Gastroskopisinde özofagus proksimalinden bafllayarak özofagogastrik bileflkeye kadar tüm özofagusu diffüz olarak tutan 0.5-1 cm boyutlar› aras›nda de¤iflen, beyaz renkte, çok say›da parmaks› ç›k›nt› fleklinde polipoid lezyonlar izlendi (fiekil 1, 2). Çok say›da lezyondan biyopsiler al›nd›. Hastan›n de¤iflik lezyonlar›ndan al›nan tüm biyopsi örnekleri skuamoz hücreli papilloma ile uyumlu idi.
TARTIfiMAGastroözofageal reflü, reflu özofajit ve hiatal herni gibi özofa-gus skuamoz hücreli papilloma etyolojisinde rol oynad›¤› dü-flünülen hastal›klar›n co¤rafik da¤›l›m› hastal›¤›n prevelans› ve yerleflim yeri ile iliflkili olabilir. ‹talya ve Japonya'da yap›-lan çal›flmalarda reflü özofajit s›kl›¤›n›n bat› ülkelerine oranla daha düflük olmas› nedeni ile bu bölgelerde özofagus...
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