Esophageal squamous papilloma lacks clear clinicopathological associations

Abstract

AIMTo determine the prevalence of esophageal squamous papillomas (ESPs) in a tertiary teaching hospital and to assess for any clinical associations, including relations with esophageal squamous cell carcinomas (SCCs).METHODSData from a total of 6962 upper gastrointestinal endoscopies over a five year period were retrospectively obtained and analysed.RESULTSESP was found in sixteen patients (0.23%). Eight (50%) patients had a high body mass index, seven (44%) had history of cigarette smoking. Reflux esophagitis was found in four (25%) patients. All ESPs were solitary with a mean endoscopic size of 3.8 mm and located in the mid to lower esophagus. Human papilloma virus (HPV) was tested in three (19%) patients and was negative. Esophageal SCC was found in seven patients (0.10%) during the same period. None of the specimens were tested for HPV, and none had associated papillomatous changes.CONCLUSIONESP is an uncommon tumour with unclear clinical associations and malignant potential.

Clinicopathological characteristics of patients with oesophageal squamous papilloma in Turkey and comparison with the literature data: The largest case series ever reported from Turkey

“…Previous studies report varying data when it comes to the most frequent locations for ESPs. Although Bohn et al 11 state that they found ESPs to be located mostly in the upper oesophageal region in their study, there are many more studies reporting that the most frequent location for ESPs is the middle and distal oesophagus 9,14 . Publications stating that ESPs are most frequently seen in the distal oesophagus also mention that the aetiology could be mucosal damage due to acid reflux 9,10,15,19 .…”

“…Comparison of studies on ESP published after 2000 with more than eight cases is given in Table 3. In previous studies, ESP prevalence was reported as 0.08%‐0.45% in Italy, 0.01% in France, 0.42% in Taiwan, 0.23% in Australia and 0.20% in Japan 4,5,13‐17 . In a previous study with the largest case series from Turkey at that time, 38 patients were determined to have squamous papilloma 18 .…”

“…In line with the literature data, the ESP prevalence was 0.44% in our study. In previous studies, ESP detection age was reported as 50s 5,14,15,19 (Table 3). In Turkey, in a study conducted by Tiftikçi et al, the mean age was found to be 41 years 18 .…”

Squamous Cell Papilloma of the Esophagus: A Case Series Highlighting Endoscopic and Histologic Features

“…Complications with squamous cell carcinoma (SCC) have been reported [3][4][5][6]; however, the small absolute number of cases makes drawing any associations or conclusions between ESP and SCC difficult [12]. Review of the literature seems to suggest malignant potential appears highest in cases where the patient is symptomatic and has multiple lesions (papillomatosis), or a particularly large lesion [5,6].…”

Esophageal squamous cell papilloma on the background of gastroesophageal reflux disease: a clinical case in a 23-year-old obese man.

“…За За оцінюванням асоціації жирових накопичень цієї ділянки з гістологічними змінами СО стравоходу, доведено, що жирова тканина розташована навколо ГЕП, може модулювати пошкодження стравоходу у вигляді запалення, метаплазії та дисплазії епітелію СО шляхом ендокринних та, можливо, паракринних механізмів [18].…”