Esophageal ulcer associated with inappropriately taken doxycycline: A benign mimicker of esophageal cancer

Sasaki, Yasutsuna; Suzuki, Takeshi; Zai, Hiroaki; Urita, Yoshihisa

doi:10.1002/jgf2.55

Cited by 11 publications

(11 citation statements)

References 7 publications

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“…This treatment strategy did not improve the patient's condition so it was changed for tetracyclines (mostly because of a broad spectrum of activity and action against gram -bacteria). Most probably the cause of the oesophageal stricture in the present case was long-term doxycycline treatment without water administration as described previously (German et al 2005;Sasaki et al 2017). Unfortunately, due to better access to doxycycline tablets and the lack of possibility of daily intravenous administration of drugs for a long time, it was decided to use this solution, despite the risk of oesophageal stricture.…”

Section: Discussionsupporting

confidence: 58%

The use of Savary-Gilliard dilators in the treatment of an oesophageal stricture in a cat

Kaczmar

Makowska

Rychlik

2021

Preprint

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Oesophageal strictures in cats and dogs are relatively rare and the cause of this disorder can be multifactorial. However, the most common cause in cats is an inflammatory process. Conservative treatment strategies for this disorder includes image-guided interventions. Endoscopic methods are a form of a minimally invasive surgical treatment of the oesophageal strictures. Several endoscopic methods for the therapy of this condition are known, one of them is Savary-Gilliard dilators technique. In the present study of a case of oesophageal stricture in a cat, caused probably by doxycycline treatment without water administration, the authors used the Savary-Gilliard dilators as a therapy for its condition. The animal underwent 3 endoscopy procedures, where in the third one no abnormality in the oesophagus was observed. Moreover, the cat was asymptomatic 6 months after the last oesophagoscopy. In the authors opinion, based on the present case, some experience of the authors and previously described studies, the Savary-Gilliard dilators seems to be a safe, effective, relatively cheap and minimally invasive method of the oesophageal stricture therapy in the cat.

show abstract

Section: Discussionsupporting

confidence: 58%

The use of Savary-Gilliard dilators in the treatment of an oesophageal stricture in a cat

Kaczmar

Makowska

Rychlik

2021

Preprint

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“…Doxycycline can potentially have multiple activities in vivo, including anti-inflammatory activities (51) and effects on the intestinal microbiota (52). Doxycycline can induce esophageal ulceration mimicking a benign form of esophageal cancer (53)(54)(55), can cause gastrointestinal injury (56,57), and can stimulate colonic tumor growth (58). On the other hand, doxycycline can also have antitumorigenic effects (59)(60)(61)(62).…”

Section: Discussionmentioning

confidence: 99%

Temporal Control of the Helicobacter pylori Cag Type IV Secretion System in a Mongolian Gerbil Model of Gastric Carcinogenesis

Lin

McClain

Beckett

et al. 2020

mBio

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The Helicobacter pylori Cag type IV secretion system (T4SS) translocates the effector protein CagA and nonprotein bacterial constituents into host cells. In this study, we infected Mongolian gerbils with an H. pylori strain in which expression of the cagUT operon (required for Cag T4SS activity) is controlled by a TetR/tetO system. Transcript levels of cagU were significantly higher in gastric tissue from H. pylori-infected animals receiving doxycycline-containing chow (to derepress Cag T4SS activity) than in tissue from infected control animals receiving drug-free chow. At 3 months postinfection, infected animals receiving doxycycline had significantly increased gastric inflammation compared to infected control animals. Dysplasia (a premalignant histologic lesion) and/or invasive gastric adenocarcinoma were detected only in infected gerbils receiving doxycycline, not in infected control animals. We then conducted experiments in which Cag T4SS activity was derepressed during defined stages of infection. Continuous Cag T4SS activity throughout a 3-month time period resulted in higher rates of dysplasia and/or gastric cancer than observed when Cag T4SS activity was limited to early or late stages of infection. Cag T4SS activity for the initial 6 weeks of infection was sufficient for the development of gastric inflammation at the 3-month time point, with gastric cancer detected in a small proportion of animals. These experimental results, together with previous studies of cag mutant strains, provide strong evidence that Cag T4SS activity contributes to gastric carcinogenesis and help to define the stages of H. pylori infection during which Cag T4SS activity causes gastric alterations relevant for cancer pathogenesis. IMPORTANCE The “hit-and-run model” of carcinogenesis proposes that an infectious agent triggers carcinogenesis during initial stages of infection and that the ongoing presence of the infectious agent is not required for development of cancer. H. pylori infection and actions of CagA (an effector protein designated a bacterial oncoprotein, secreted by the Cag T4SS) are proposed to constitute a paradigm for hit-and-run carcinogenesis. In this study, we report the development of methods for controlling H. pylori Cag T4SS activity in vivo and demonstrate that Cag T4SS activity contributes to gastric carcinogenesis. We also show that Cag T4SS activity during an early stage of infection is sufficient to initiate a cascade of cellular alterations leading to gastric inflammation and gastric cancer at later time points.

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“…This treatment strategy did not improve the patient's condition so it was changed for tetracyclines (mostly because of a broad spectrum of activity and action against gram -bacteria). Most probably the cause of the oesophageal stricture in the present case was longterm doxycycline treatment without water administration as described previously (German et al 2005;Sasaki et al 2017). Unfortunately, due to better access to doxycycline tablets and the lack of possibility of daily intravenous administration of drugs for a long time, it was decided to use this solution, despite the risk of oesophageal stricture.…”

Section: Discussionmentioning

confidence: 68%

The use of Savary-Gilliard dilators in the treatment of an oesophageal stricture in a cat

2022

View full text Add to dashboard Cite

Oesophageal strictures in cats and dogs are relatively rare and the cause of this disorder can be multifactorial. However, the most common cause in cats is an inflammatory process.Conservative treatment strategies for this disorder includes image-guided interventions. Endoscopic methods are a form of a minimally invasive surgical treatment of the oesophageal strictures. Several endoscopic methods for the therapy of this condition are known, one of them is Savary-Gilliard dilators technique.In the present study of a case of oesophageal stricture in a cat, caused probably by doxycycline treatment without water administration, the authors used the Savary-Gilliard dilators as a therapy for its condition. The animal underwent 3 endoscopy procedures, where in the third one no abnormality in the oesophagus was observed. Moreover, the cat was asymptomatic 6 months after the last oesophagoscopy.In the authors opinion, based on the present case, some experience of the authors and previously described studies, the Savary-Gilliard dilators seems to be a safe, effective, relatively cheap and minimally invasive method of the oesophageal stricture therapy in the cat.

show abstract

Esophageal ulcer associated with inappropriately taken doxycycline: A benign mimicker of esophageal cancer

Cited by 11 publications

References 7 publications

The use of Savary-Gilliard dilators in the treatment of an oesophageal stricture in a cat

The use of Savary-Gilliard dilators in the treatment of an oesophageal stricture in a cat

Temporal Control of the Helicobacter pylori Cag Type IV Secretion System in a Mongolian Gerbil Model of Gastric Carcinogenesis

The use of Savary-Gilliard dilators in the treatment of an oesophageal stricture in a cat

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