Esophagitis

Infectious Strictures Requiring Esophageal Replacement in Children

“…The definitive diagnosis of herpes esophagitis is based on biopsy findings consisting of the presence of epithelial cells with spherical eosinophilic intranuclear bodies surrounded by a pale zone in addition to enlarged, apparently multinucleated cells and some cytoplasmic changes (19). However, the presence of multinucleated cells does not always reflect the viral origin of the disease (20), and immunohistochemical and electromicroscopic investigation may be necessary (21–23).…”