Esophagitis Dissecans Superficialis after COVID-19; A Case Report

Salehi, Amir Mohammad; Salehi, Hossain; Hasanzarrini, Maryam

doi:10.34172/mejdd.2022.293

Cited by 7 publications

(6 citation statements)

References 11 publications

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“…EDS, also known as sloughing esophagitis, is a benign yet rare pathological finding with less than 100 cases described in the literature. It distinctly appears as columns of peeling mucosa with normal underlying esophageal tissue on upper endoscopy [ 1 ]. Histopathology further reveals parakeratosis and intraepithelial splitting, although it is nonspecific and can be misinterpreted as Candida esophagitis [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…Despite its seemingly striking appearance, complete healing without complications is frequently achieved following the withdrawal of offending agents. It mostly affects those of older age on multiple medications, although the mechanism remains unclear [ 1 , 2 ]. We present a case of an 81-year-old female diagnosed with EDS following an acute 8-pound weight loss.…”

Section: Introductionmentioning

confidence: 99%

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Esophagitis Dissecans Superficialis: A Case Report

Zaher,

Patel,

Zaher

2023

Cureus

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Esophagitis dissecans superficialis (EDS) is a rare esophageal lesion characterized by sloughing of the esophageal mucosa. Typically asymptomatic and histopathologically nonspecific, diagnosis relies on endoscopic appearance. We report a case of an 81-year-old female who presented with an 8-pound weight loss in two weeks. Upper endoscopy showed severe mucosal changes with sloughing in the lower esophagus, consistent with EDS. Histopathology confirmed the diagnosis. No offending agents were identified, and high-dose proton pump inhibitors (PPIs) were initiated, resulting in symptom improvement. EDS remains poorly understood; it is associated with medication use, esophageal motility disorders, and autoimmune conditions. EDS should be considered in unexplained weight loss cases, with treatment focused on the discontinuation of culprits and PPI therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Esophagitis Dissecans Superficialis: A Case Report

Zaher,

Patel,

Zaher

2023

Cureus

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“…Moreover, the receptors of the angiotensin 2-converting enzyme are expressed in the gastric cells. Therefore, it is possible that SARS-CoV-2 can cause gastritis, PUD, GIB and in rare cases esophagitis dissecans superficialis [ 18 , 19 ]. However, the underlying mechanisms of vaccine-induced PUD are unclear.…”

Section: Discussionmentioning

confidence: 99%

Development of Peptic Ulcer following Second Shot of Sputnik V Vaccine: A Case Report and Literature Review of Rare Side Effects of Sputnik V Vaccine

Hasanzarrini,

Salehi,

Nirumandi Jahromi

2023

Case Reports in Infectious Diseases

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Considering the global spread of the coronavirus disease 2019 (COVID-19), it is expected that vaccination against its causative agent, the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), will reduce the related morbidity and mortality. However, the safety of the COVID-19 vaccines and their potential and unknown side effects are a matter of concern. With the ongoing development and implementation of COVID-19 vaccination programs around the world, the side effects, safety, and effectiveness of these vaccines are gradually being reported, providing researchers with valuable information that can affect the production and utilization of the COVID-19 vaccines. The present study intended to report a case of peptic ulcer disease (PUD) development following vaccination with Gam-COVID-Vac, a vector-based COVID‐19 vaccine containing two recombinant human adenoviruses (rAd26 and rAd5).

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“…To our knowledge, however, the oral‐coronavirus connection is unique due to the increased mortality risk and extended multiple tissue morbidity through PASC. Multiple studies have reported increased risk for respiratory, oesophageal‐intestinal, cardiovascular, renal, and neurologic‐brain disorders in COVID‐19 patients 25–30 . We propose that periopathogen‐derived metabolites and enzymes depress the host oral mucosal resistance and extend the initial oral infection systemically.…”

Section: Introductionmentioning

confidence: 88%

“…Multiple studies have reported increased risk for respiratory, oesophageal-intestinal, cardiovascular, renal, and neurologic-brain disorders in COVID-19 patients. [25][26][27][28][29][30] We propose that periopathogen-derived metabolites and enzymes depress the host oral mucosal resistance and extend the initial oral infection systemically. Further, PD pathogen-driven attenuation of host oral mucosal immunity targets the microbiome organization and perpetuates the survival of selective pathogens.…”

Section: Introductionmentioning

confidence: 99%

SARS‐CoV‐2, periodontal pathogens, and host factors: The trinity of oral post‐acute sequelae of COVID‐19

Schwartz,

Capistrano,

Gluck

et al. 2024

Reviews in Medical Virology

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COVID‐19 as a pan‐epidemic is waning but there it is imperative to understand virus interaction with oral tissues and oral inflammatory diseases. We review periodontal disease (PD), a common inflammatory oral disease, as a driver of COVID‐19 and oral post‐acute‐sequelae conditions (PASC). Oral PASC identifies with PD, loss of teeth, dysgeusia, xerostomia, sialolitis‐sialolith, and mucositis. We contend that PD‐associated oral microbial dysbiosis involving higher burden of periodontopathic bacteria provide an optimal microenvironment for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. These pathogens interact with oral epithelial cells activate molecular or biochemical pathways that promote viral adherence, entry, and persistence in the oral cavity. A repertoire of diverse molecules identifies this relationship including lipids, carbohydrates and enzymes. The S protein of SARS‐CoV‐2 binds to the ACE2 receptor and is activated by protease activity of host furin or TRMPSS2 that cleave S protein subunits to promote viral entry. However, PD pathogens provide additional enzymatic assistance mimicking furin and augment SARS‐CoV‐2 adherence by inducing viral entry receptors ACE2/TRMPSS, which are poorly expressed on oral epithelial cells. We discuss the mechanisms involving periodontopathogens and host factors that facilitate SARS‐CoV‐2 infection and immune resistance resulting in incomplete clearance and risk for ‘long‐haul’ oral health issues characterising PASC. Finally, we suggest potential diagnostic markers and treatment avenues to mitigate oral PASC.

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Esophagitis Dissecans Superficialis after COVID-19; A Case Report

Cited by 7 publications

References 11 publications

Esophagitis Dissecans Superficialis: A Case Report

Esophagitis Dissecans Superficialis: A Case Report

Development of Peptic Ulcer following Second Shot of Sputnik V Vaccine: A Case Report and Literature Review of Rare Side Effects of Sputnik V Vaccine

SARS‐CoV‐2, periodontal pathogens, and host factors: The trinity of oral post‐acute sequelae of COVID‐19

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