Esophagitis: Old Histologic Concepts and New Thoughts

Grin, Andrea; Streutker, Catherine

doi:10.5858/arpa.2014-0132-ra

Cited by 20 publications

(28 citation statements)

References 44 publications

(52 reference statements)

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“…EDS is characterized by sloughing of large fragments of the esophageal mucosa and has been described as “sloughing esophagitis” [2, 3]. EDS has been associated with medications such as bisphosphonates, non-steroidal anti-inflammatory drugs (NSAIDS), potassium chloride, and systemic diseases including celiac disease, collagen vascular disorders, and autoimmune bullous dermatoses.…”

Section: Discussionmentioning

confidence: 99%

Fungal Esophagitis Presenting With Esophagitis Dissecans Superficialis: Cause or Concurrence? A Diagnostic Conundrum

et al. 2016

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Esophagitis dissecans superficialis (EDS) is a rare desquamative disorder of the esophagus. It is characterized by sheets of sloughed squamous tissue with normal underlying mucosa. We present a case of a 68-year-old man with severe anemia and a positive fecal occult blood test who was found to have features suggestive of EDS during endoscopy. However, histological features were suggestive of both EDS and fungal esophagitis. To our knowledge, this is the first reported case in literature which discusses the clinical scenario of fungal infection being a possible etiology rather than a commonly accepted differential diagnosis of EDS. We also review the clinical features, diagnostic criteria and treatment of EDS.

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Section: Discussionmentioning

confidence: 99%

Fungal Esophagitis Presenting With Esophagitis Dissecans Superficialis: Cause or Concurrence? A Diagnostic Conundrum

et al. 2016

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“…For example, erosive gastroesophageal reflux disease (GERD), infections (especially Candida spp. and Herpes simplex virus), and pill esophagitis are associated with marked neutrophilic epithelial injury, erosion, and ulcer formation . Eosinophilic esophagitis, GERD, parasitic infections, Crohn's disease, drug hypersensitivity, hypereosinophilic syndrome, celiac disease, vasculitis, and collagen vascular disorders are commonly associated with increased intraepithelial eosinophils .…”

Section: Squamous Epithelial Injurymentioning

confidence: 99%

“…and Herpes simplex virus), and pill esophagitis are associated with marked neutrophilic epithelial injury, erosion, and ulcer formation. 13 Eosinophilic esophagitis, GERD, parasitic infections, Crohn's disease, drug hypersensitivity, hypereosinophilic syndrome, celiac disease, vasculitis, and collagen vascular disorders are commonly associated with increased intraepithelial eosinophils. 14 Lymphocytes tend to be a predominant component of inflammatory cells in chronic GERD, drugs-/medications-related injury, Crohn's disease (especially children), achalasia/motility disorders, autoimmune diseases, immunodeficiency (e.g., HIV and CVID), celiac disease, as well as dermatologic conditions, among others.…”

Section: Inflammatory Responsementioning

confidence: 99%

The microscopic anatomy of the esophagus including the individual layers, specialized tissues, and unique components and their responses to injury

Zhang

Patil

Odze

et al. 2018

Annals of the New York Academy of Sciences

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The esophagus, a straight tube that connects the pharynx to the stomach, has the complex architecture common to the rest of the gastrointestinal tract with special differences that relate to its function as a conduit of ingested substances. For instance, it has submucosal glands that are unique and have a specific protective function. It has a squamous lining that exists nowhere else in the gut except the anus and it has a different submucosal nerve plexus when compared to the stomach and intestines. All of the layers of the esophageal wall and the specialized structures including blood and lymphatic vessels and nerves have specific responses to injury. The esophagus also has unique features such as patches of gastric mucosa called inlet patches at the very proximal part and it has a special sphincter mechanism at the most distal aspect. This review covers the normal microscopic anatomy of the esophagus and the patterns of reaction to stress and injury of each layer and each special structure.

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Section: Histological Diagnosis Of Refluxmentioning

confidence: 99%

“…Other than bland diets and milk consumption, antacids remained the mainstay of GERD treatment until the 1970s when more specific acid blockers, such as histamine blockers and eventually proton pump inhibitors, became available. These medications are now used by a large proportion of the North American population, corresponding to the large proportion of the population having GERD …”

Section: Introductionmentioning

confidence: 99%

Relevance of histology in the diagnosis of reflux esophagitis

Tripathi

Streutker

Marginean

2018

Annals of the New York Academy of Sciences

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Reflux esophagitis is an important clinical diagnosis; however, the histologic findings can be nonspecific and overlap with other entities. Various benign changes can produce diagnostic difficulties for pathologists. In this review, the typical histologic findings of gastroesophageal reflux disease (GERD) of the esophagus are discussed, along with the issues relating to clinical correlation and technical aspects of endoscopic biopsies and specimen processing. The literature has been reviewed to discuss histologic definitions of GERD as well as current and developing controversies in the area of GERD. Histologic features are not entirely sensitive or specific for GERD. Awareness of these problems is essential; clinical and endoscopic information can be very useful in distinguishing GERD from other inflammatory lesions.

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Esophagitis: Old Histologic Concepts and New Thoughts

Abstract: Histologic features are not entirely sensitive and specific for inflammatory esophageal disorders. Awareness of these problems is essential; clinical and endoscopic information can be very useful in distinguishing among the various lesions.

Cited by 20 publications

References 44 publications

Fungal Esophagitis Presenting With Esophagitis Dissecans Superficialis: Cause or Concurrence? A Diagnostic Conundrum

Fungal Esophagitis Presenting With Esophagitis Dissecans Superficialis: Cause or Concurrence? A Diagnostic Conundrum

The microscopic anatomy of the esophagus including the individual layers, specialized tissues, and unique components and their responses to injury

Relevance of histology in the diagnosis of reflux esophagitis

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