The patient was a 73-year-old woman with Parkinsonʼs disease, for which she was receiving medical treatment. She was referred to our hospital with a 2-day history of fever and dyspnea. The patient was diagnosed as having an esophageal ulcer with pericardial perforation, based on the findings of chest and abdominal contrast-enhanced CT and upper gastrointestinal endoscopy. Both surgical treatment under general anesthesia and percutaneous pericardial drainage were considered, but due to the patientʼs poor nutritional status, percutaneous drainage was performed. After drainage, antibiotic therapy, and enteral feeding, the inflammatory response improved and the fistula closed, and the patient was transferred to another hospital on day 54. The patient had no risk factors for an esophageal ulcer, such as a history of gastrointestinal surgery or radiation therapy, or medication, and no obvious precipitating factors could be identified.