Espondilodiscitis con absceso intrarraquídeo y paraespinal causada por bacilo de Calmette-Guérin (BCG)

Lara-Oya, Ana; Ramírez-Taboada, Jessica; Arenas-Miras, Mar; Rodríguez‐Grangér, Javier

doi:10.4067/s0716-10182015000700015

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Since 1992, 25 cases of M. bovis BCG vertebral osteomyelitis following instillations for bladder cancer have been reported in English literature and two cases in non-English literature [32,33]. Other articles with M. bovis BCG infection and spinal pain have been published [34][35][36], but they were not consistent with a vertebral osteomyelitis diagnosis.…”

Section: Reviewmentioning

confidence: 99%

Back pain following instillations of BCG for superficial bladder cancer is not a reactive complication: review of 30 Mycobacterium bovis BCG vertebral osteomyelitis cases

et al. 2019

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Introduction: Mycobacterium bovis BCG instillations are used in bladder cancer treatment. Adverse effects can occur. Osteoarticular complications are mainly reactive arthritis, but true infections have been described, such as vertebral osteomyelitis. Methods: We made a review of M. bovis BCG vertebral osteomyelitis after instillations for bladder cancer using PubMed search. We added 3 new French cases. Review: Twenty-seven cases of BCG vertebral osteomyelitis had been reported on PubMed. Of the 30 cases, all were male, averaging 73.4 ± 8.7 year-old. Median time between diagnosis and first and last instillation was 22.5 months and 14 months respectively. Half of vertebral osteomyelitis was thoracic, and lumbar in the other half. Sensitivomotor deficit was present at diagnosis in 42% of cases. Other infectious locations were common, mainly infectious abdominal aortic aneurysms (20%). Rifampicin, ethambutol and isoniazid were the usual therapy. Poor outcomes were reported with 50% of one or more spine surgery. Conclusion: M. bovis BCG vertebral osteomyelitis following bladder instillation for bladder cancer is a rare complication. However, the late onset of back pain after instillations differentiates them from reactive arthritis. Concomitant septic location such as infectious abdominal aortic aneurysms must be known.

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Section: Reviewmentioning

confidence: 99%

Back pain following instillations of BCG for superficial bladder cancer is not a reactive complication: review of 30 Mycobacterium bovis BCG vertebral osteomyelitis cases

et al. 2019

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Mycobacterium bovisBCG spinal osteomyelitis in a patient with bladder cancer without a history of BCG instillation

Gupte¹,

Matcha²,

Lauzardo

2018

BMJ Case Reports

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BCG has been used as intravesical immunotherapy for the treatment of bladder carcinoma. However, this treatment is not harmless and may lead to complications, with a reported incidence of systemic BCG infection ranging from 3% to 7%. We report a case of culture-proven (BCG) vertebral osteomyelitis in a 72-year-old patient with bladder carcinoma who was treated with intravesical mitomycin C but did not receive BCG. Cultures from biopsy recovered isolate resembling biochemically, but resistant to pyrazinamide (PZA). The patient was originally started on a four-drug antituberculous regimen of isoniazid, rifampin, ethambutol and PZA. After genotypic analysis identified the organism as (BCG), the regimen was changed to isoniazid and rifampin for 12 months. The patient responded well tothis treatment. This case is unique as the patient received only intravesical mitomycin and did not receive BCG, implying the possibility of transmission from contaminated equipment.

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Espondilodiscitis con absceso intrarraquídeo y paraespinal causada por bacilo de Calmette-Guérin (BCG)

Cited by 2 publications

References 12 publications

Back pain following instillations of BCG for superficial bladder cancer is not a reactive complication: review of 30 Mycobacterium bovis BCG vertebral osteomyelitis cases

Back pain following instillations of BCG for superficial bladder cancer is not a reactive complication: review of 30 Mycobacterium bovis BCG vertebral osteomyelitis cases

Mycobacterium bovisBCG spinal osteomyelitis in a patient with bladder cancer without a history of BCG instillation

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