Esporotricosis cutánea diseminada con compromiso articular en una mujer con diabetes tipo 2

Solorzano, Sendy; Ramirez, Renán; Cabada, Miguel M.; Montoya, Manuel; Cazorla, Ernesto

doi:10.17843/rpmesp.2015.321.1593

Cited by 8 publications

(3 citation statements)

References 11 publications

(15 reference statements)

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“…The most emblematic case of disseminated disease occurred in a diabetic and alcoholic patient who developed a fatal fungemia after 17 days of hospitalization [110]. The other cases corresponded to isolated monoarthritis, endophthalmitis and cutaneous disseminated sporotrichosis [111,112,113].…”

Section: Comorbidities As Risk Factors For Sporotrichosismentioning

confidence: 99%

Sporotrichosis In Immunocompromised Hosts

Queiroz‐Telles

Buccheri

Benard

2019

JoF

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Sporotrichosis is a global implantation or subcutaneous mycosis caused by several members of the genus Sporothrix, a thermo-dimorphic fungus. This disease may also depict an endemic profile, especially in tropical to subtropical zones around the world. Interestingly, sporotrichosis is an anthropozoonotic disease that may be transmitted to humans by plants or by animals, especially cats. It may be associated with rather isolated or clustered cases but also with outbreaks in different periods and geographic regions. Usually, sporotrichosis affects immunocompetent hosts, presenting a chronic to subacute evolution course. Less frequently, sporotrichosis may be acquired by inhalation, leading to disseminated clinical forms. Both modes of infection may occur in immunocompromised patients, especially associated with human immunodeficiency virus (HIV) infection, but also diabetes mellitus, chronic alcoholism, steroids, anti-TNF treatment, hematologic cancer and transplanted patients. Similar to other endemic mycoses caused by dimorphic fungi, sporotrichosis in immunocompromised hosts may be associated with rather more severe clinical courses, larger fungal burden and longer periods of systemic antifungal therapy. A prolonged outbreak of cat-transmitted sporotrichosis is in progress in Brazil and potentially crossing the border to neighboring countries. This huge outbreak involves thousands of human and cats, including immunocompromised subjects affected by HIV and FIV (feline immunodeficiency virus), respectively. We reviewed the main epidemiologic, clinical, diagnostic and therapeutic aspects of sporotrichosis in immunocompromised hosts.

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Section: Comorbidities As Risk Factors For Sporotrichosismentioning

confidence: 99%

Sporotrichosis In Immunocompromised Hosts

Queiroz‐Telles

Buccheri

Benard

2019

JoF

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“…The most frequent predisposing factor of CDS was HIV-AIDS [ 3 , 21 – 24 ], usually occurring in patients in stage C of AIDS (CD4+ count <200 cells/ mm 3 ) [ 3 , 17 ]. Second, CDS can be caused by uncontrolled diabetes [ 3 , 4 , 25 ]. Overall, the condition may be attributed to immunological deterioration related to cellular response, especially macrophage dysfunction [ 3 , 4 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…The most frequent predisposing factor of CDS was HIV-AIDS [3,[21][22][23][24], usually occurring in patients in stage C of AIDS (CD4+ count <200 cells/ mm 3 ) [3,17]. Second, CDS can be caused by uncontrolled diabetes [3,4,25]. Overall, the condition may be attributed to…”

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

Cutaneous disseminated sporotrichosis associated with diabetes: A case report and literature review

Xia,

Zhi,

Liu

2023

PLoS Negl Trop Dis

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Background Cutaneous disseminated sporotrichosis (CDS), also called hematogenous sporotrichosis, is a rare condition that usually affects immunocompromised patients. The current work presents the case of a woman with diabetes mellitus associated with CDS. Case presentation A 59-year-old woman with diabetes mellitus presented with a two-year history of ulcerated rashes on the left ankle and both sides of the jaw. Physical examination revealed three annular areas of erythematous and raised plaque with an ulcer over the left ankle and both sides of the jaw. Based on laboratory findings, elevated blood glucose concentration and decreased white cell count were observed. Sporothrix globosa was identified in the mycological culture of biopsied tissue from the three lesions and this was confirmed by DNA sequencing. The skin lesions healed after two-month itraconazole therapy. Conclusions Diabetes is a risk factor for disseminated sporotrichosis, which may be induced by hematogeneous spread, repeated inoculation, or autoinoculation. This study raises awareness among clinicians, with regard to the notion that people with possibly altered immune function are potentially vulnerable to severe clinical forms of sporotrichosis.

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Other Fungal Arthritis

Gómez

Hoyos

2019

Infections and the Rheumatic Diseases

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Esporotricosis cutánea diseminada con compromiso articular en una mujer con diabetes tipo 2

Cited by 8 publications

References 11 publications

Sporotrichosis In Immunocompromised Hosts

Sporotrichosis In Immunocompromised Hosts

Cutaneous disseminated sporotrichosis associated with diabetes: A case report and literature review

Other Fungal Arthritis

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