ESR and cell culture studies on free radical-scavenging and antioxidant activities of isoflavonoids

Guo, Qingbin; Rimbach, Gerald; Moini, Hadi; Weber, Stefan; Packer, Lester

doi:10.1016/s0300-483x(02)00241-x

Cited by 131 publications

(77 citation statements)

References 26 publications

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“…Natural flavonoids and isoflavonoids have been found to influence intercellular redox status, to interact with specific proteins in intracellular signalling pathways, and to have antioxidant properties [1,2]. Of these two groups, due to their structural diversity, the structure-activity relationships (SARs) of flavonoids have been well studied using various antioxidant activity assays [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Structure and Antioxidant Activity Relationships of Isoflavonoids from Dalbergia parviflora

et al. 2014

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Abstract:The antioxidant activities of 24 isoflavonoids that were previously isolated as pure compounds from Dalbergia parviflora were evaluated using three different in vitro antioxidant-based assay systems: xanthine/xanthine oxidase (X/XO), ORAC, and DPPH. The isolates consisted of three subgroups, namely isoflavones, isoflavanones, and isoflavans, each of which appeared to have diversified substituents, and were thus ideal for the study of their structure-activity relationships (SARs). The SAR analysis was performed using the results obtained from both the inter-subgroup isoflavonoids with the same substitution pattern and the intra-subgroup compounds with different substitution patterns. The inter-subgroup comparison showed that the isoflavones exhibited the highest antioxidant activities based on all three assays. The intra-subgroup analysis showed that the additional presence of an OH group in Ring B at either R3′ or R5′ from the basic common structure of the R7-OH of Ring A and the R4′-OH (or -OMe) of Ring B greatly increased the antioxidant activities of all of the isoflavonoid subgroups and that other positions of OH and OMe substitutions exerted different effects on the activities depending on the subgroup and assay type. Therefore, based on the structural diversity of the isoflavonoids

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Section: Introductionmentioning

confidence: 99%

Structure and Antioxidant Activity Relationships of Isoflavonoids from Dalbergia parviflora

et al. 2014

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“…43) Isoflavonoids play an important role in prevention of breast cancer, prostrate cancer and atherosclerosis. 52) This accounts for the anti tumour property of the drug through modulating the ROS and lipid peroxidation.…”

Section: Resultsmentioning

confidence: 99%

Therapeutic Efficacy of Kalpaamruthaa on Lipid Peroxidation and Antioxidant Status in Experimental Mammary Carcinoma in Rats

Ramprasath

Shanthi

Sachdanandam

2006

JOURNAL OF HEALTH SCIENCE

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There has been a growing interest in studying the role played by lipid peroxidation and antioxidant status in breast cancer. Free radicals are found to be involved in both initiation and promotion of multistage carcinogenesis. In the present study, effects of Kalpaamruthaa (KA), a modified Siddha preparation on the levels of lipid peroxides (LPO) and status of antioxidants in several tissues were studied in mammary carcinoma rats. The levels of reactive oxygen species (ROS) were also measured in the control and experimental animals. A significant increase in the levels of LPO, ROS and a decreased levels of antioxidants observed in mammary carcinoma bearing rats were found to be reverted back to near normal levels on treatment with KA. Simultaneous treatment with KA showed more effect than post treatment with KA. Drug control animals showed no significant changes in the levels of ROS when compared with control animals. These results suggest that the free radical mediated damage during mammary carcinoma could have been controlled by KA by its free radical quenching and antioxidative potential. The above results also show that KA exert its anticancer effect on the development of breast cancer.

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“…Soy isoflavones, genistein and daidzein have strong antioxidant activity (Guo et al, 2002). Combination of isoflavones including genistein and daidzein has more pronounced inhibitory effects on breast cancer cell proliferation (Verma and Goldin, 1998).…”

Section: Discussionmentioning

confidence: 99%

Genistein and Daidzein, in Combination, Protect Cellular Integrity During 7,12-Dimethylbenz[a]anthracene (Dmba) Induced Mammary Carcinogenesis in Sprague-Dawley Rats

Pugalendhi¹,

Manoharan²,

Suresh³

et al. 2011

Afr. J. Trad. Compl. Alt. Med.

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The status of glycoconjugates (protein bound hexose, hexosamine, sialic acid and fucose) in plasma or serum serve as potential biomarkers for assessing tumor progression and therapeutic interventions. Aim of the present study was to investigate the protective effect of two major soy isoflavones, genistein and daidzein, in combination on the status of glycoconjugates in plasma, erythrocyte membrane and mammary tissues during 7,12-dimethylbenz[a]anthracene (DMBA) induced mammary carcinogenesis in female Sprague-Dawley rats. A single subcutaneous injection of DMBA (25 mg rat -1 ) in the mammary gland developed mammary carcinoma in female Sprague-Dawley rats. Elevated levels of plasma and mammary tissue glycoconjugates accompanied by reduction in erythrocyte membrane glycoconjugates were observed in rats bearing mammary tumors. Oral administration of genistein + daidzein (20 mg + 20 mg kg -1 bw/day) to DMBA treated rats significantly (p< 0.05) brought back the status of glycoconjugates to near normal range. The present study thus demonstrated that genistein and daidzein in combination protected the structural integrity of the cell surface and membranes during DMBA-induced mammary carcinogenesis.

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ESR and cell culture studies on free radical-scavenging and antioxidant activities of isoflavonoids

Cited by 131 publications

References 26 publications

Structure and Antioxidant Activity Relationships of Isoflavonoids from Dalbergia parviflora

Structure and Antioxidant Activity Relationships of Isoflavonoids from Dalbergia parviflora

Therapeutic Efficacy of Kalpaamruthaa on Lipid Peroxidation and Antioxidant Status in Experimental Mammary Carcinoma in Rats

Genistein and Daidzein, in Combination, Protect Cellular Integrity During 7,12-Dimethylbenz[a]anthracene (Dmba) Induced Mammary Carcinogenesis in Sprague-Dawley Rats

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