ESRRG-controlled downregulation of KCNN1 in primary sensory neurons is required for neuropathic pain
Huixing Wang,
Wanhong Zuo,
Xiaozhou Feng
et al.
Abstract:Peripheral nerve injury–induced neuronal hyperactivity in the dorsal root ganglion (DRG) participates in neuropathic pain. The calcium-activated potassium channel subfamily N member 1 (KCNN1) mediates action potential afterhyperpolarization (AHP) and gates neuronal excitability. However, the specific contribution of DRG KCNN1 to neuropathic pain is not yet clear. We report that chronic constriction injury (CCI) of the unilateral sciatic nerve or unilateral ligation of the fourth lumbar nerve produced the downr… Show more
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