ESSENCE‐Q obtained in routine Japanese public child health check‐ups may be a valuable tool in neurodevelopmental screening

Hatakenaka, Yuhei; Maeda, Masato; Ninomiya, Hitoshi; Hachiya, Koutaro; Fernell, Elisabeth; Gillberg, Christopher

doi:10.1111/apa.15029

Cited by 12 publications

(24 citation statements)

References 26 publications

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“…The mothers completed the ESSENCE-Q again, and specialists completed the ESSENCE-Q based on the observation of behaviors of the children and interviews with the mothers; in addition to the information recorded at the health checkups, all developmental areas under the ESSENCE umbrella, ie, general development, motor development, reaction to sensory stimuli, communication/language, activity/impulsiveness, social interrelatedness, attention, behavior, mood, sleep, eating and history of consciousness disturbance, were evaluated. 2 , 3 The Kyoto Scale of Psychological Development 2001 (KSPD2001), 23 the psychometric property comparable to Bayley Scales of Infant Development second edition (BSID-II), was used to evaluate cognitive function. Diagnostic Interview for Social and Communication Disorders (DISCO-10) 24 was used to assess the development of sociability and communication.…”

Section: Methodsmentioning

confidence: 99%

“…The evaluation criteria are as follows: poor, UI± < 0.2; fair, 0.2 ≤ UI± < 0.4; moderate, 0.4 ≤ UI± < 0.6; good, 0.6 ≤ UI± < 0.8 and very good, UI± ≥ 0.8. 3 , 31 We searched for a combination of motor development abnormalities for which the posterior probability exceeded the optimal cut-off value described above. …”

Section: Methodsmentioning

confidence: 99%

“…The evaluation criteria are as follows: poor, UI± < 0.2; fair, 0.2 ≤ UI± < 0.4; moderate, 0.4 ≤ UI± < 0.6; good, 0.6 ≤ UI± < 0.8 and very good, UI± ≥ 0.8. 3 , 31…”

Section: Methodsmentioning

confidence: 99%

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How Accurately Does the Information on Motor Development Collected During Health Checkups for Infants Predict the Diagnosis of Neurodevelopmental Disorders? – A Bayesian Network Model-Based Study

Hatakenaka¹,

Hachiya²,

Ikezoe³

et al. 2022

NDT

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Purpose We investigated to what extent early motor development problems predict a future diagnosis of neurodevelopmental disorders (NDDs)/Early Symptomatic Syndromes Eliciting Neurodevelopmental Examinations (ESSENCE) by using a Bayesian network model (BN). Subjects and methods Subjects were the children who had participated in the 18- and 36-month checkups in two cities in Japan between April 2014 and March 2015. Their motor development data at the 4-, 10- and 18-month-checkups were collected with ethical consideration. The diagnosis was confirmed at the age of six, after regular assessment in all developmental areas at a neurodevelopmental clinic. The accuracy of prediction of NDD based on posterior probabilities determined using the BN was evaluated using the area under the receiver operating characteristic (ROC) curve (AUC). The posterior probability (the optimal cut-off value) yielding the maximum Youden Index (sensitivity + specificity – 1) is determined with the ROC curve, and the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and utility index (UI) were computed. Results BN models showed associations between early motor items and developmental coordination disorders, borderline intelligence/intellectual disability, and speech and language disorder. The ROC curve for any NDD had an AUC of 0.735. The posterior probability with the maximal Youden Index was 0.138; at the optimal cut-off value, the sensitivity, specificity, PPV, NPV, UI+, and UI- were 0.619, 0.761, 0.250, 0.940, 0.155 and 0.715, respectively. Conclusion We utilized a novel approach in detailing the associations between certain early motor problems and specific NDDs. We showed that the presence of motor development problems early in development increases the probability of a future diagnosis of any NDD. Still, the sensitivity of early motor development problems as a screening tool was not high enough to be the sole instrument for detecting NDDs. The need for a broad, holistic ESSENCE perspective when looking at the course of motor development problems was stressed.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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How Accurately Does the Information on Motor Development Collected During Health Checkups for Infants Predict the Diagnosis of Neurodevelopmental Disorders? – A Bayesian Network Model-Based Study

Hatakenaka¹,

Hachiya²,

Ikezoe³

et al. 2022

NDT

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“…It is currently used in clinical and research contexts and has been validated in population-based and clinical samples in Japan and Europe, mostly in pre-school aged children. [9][10][11] One study investigated teacher-rated ESSENCE-Q in Swedish schoolaged children, but validation was restricted to intellectual functioning, showing that BIF was associated with higher teacher ESSENCE-Q-scores. 12 No school-based studies have established its validity in relation to other clinical-level problem groups.…”

Section: Introductionmentioning

confidence: 99%

“…Hatakenaka et al investigated the validity of ESSENCE-Q in detecting NDDs in three studies of preschool-aged children, one cohort referred for a work-up for NDDs, and two cohorts attending regular public health check-ups. 11,33,34 There was a high prevalence of NDDs in the studies of public health check-ups (9% and 17%). With the exception of ratings at 20 months of age, the AUC of ESSENCE-Q rated by mothers was low, whereas expert-rated ESSENCE-Q (by nurse or psychologist) showed good predictive validity with scores of 2 or 3 used as cutoff.…”

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confidence: 99%

The ESSENCE-Questionnaire for Neurodevelopmental Problems – A Swedish School-Based Validation Study in 11-Year-Old Children

Landgren¹,

Svensson²,

Knez³

et al. 2022

NDT

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Purpose To determine the prevalence of parent-rated developmental concern using the ESSENCE-Q (Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations-Questionnaire, 12-items, score range 0–24) and to ascertain the predictive validity and optimal cutoff level of the instrument in a school-based sample of 11-year-old children. Methods In a cross-sectional, school-based study, participants underwent a clinical assessment by a physician and a psychologist, teachers and parents completed the SDQ (Strength and Difficulties Questionnaire), medical health records and national tests were reviewed, and parents independently completed the ESSENCE-Q. In a case-conference outcomes were defined as a) the need for further clinical work-up due to suspected neurodevelopmental problems (NDPs) and b) degree of investigator-rated symptoms/impairment from NDPs on the CGI-S (Clinical Global Impression-Severity instrument, range 1–7, 4–7 defined as clinically symptomatic). Classification and optimal cutoffs of the ESSENCE-Q were determined using ROC (Receiver Operating Characteristic) analysis. Results Out of 343 eligible children, 223 enrolled, of whom 173 (50% of all eligible) had a parent-rated ESSENCE-Q. At least one of the 12 possible concerns was reported by parents of 36% of participants. Overall, in 101 (57%) participants a work-up was warranted, and 64 (37%) were clinically symptomatic from NDPs. The AUC of the ESSENCE-Q in detecting need for work-up was 0.70 (95% confidence interval [CI] 0.63–0.77), and the AUC in detecting clinically symptomatic participants was 0.82 (95% CI 0.76–0.88). ESSENCE-Q ratings correlated positively with CGI-S scores ( r =0.48, p <0.05). A cutoff of ≥3 had the highest accuracy (78%) with a negative predictive value of 82%. Ratings >6 conferred few false positives cases with positive likelihood ratios >10 and positive predictive values of 86% or more. Significance This study of the ESSENCE-Q in 11-year-old children suggests it might be an acceptable instrument for screening of NDPs in children in middle school, optimally in conjunction with other methods.

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Early neurodevelopmental problems and risk for avoidant/restrictive food intake disorder (ARFID) in 4‐7‐year‐old children: A Japanese birth cohort study

et al. 2022

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Background: An overrepresentation of neurodevelopmental problems (NDPs) has been observed in individuals with avoidant/restrictive food intake disorder (ARFID).Previous studies on the association between ARFID and NDPs have been limited by cross-sectional data from clinical samples of small size. This study aimed to extend previous research by using prospectively collected data in a non-clinical child cohort.We examined the occurrence of early NDPs in 4-7-year-old children with suspected ARFID and how predictive early NDPs are of ARFID. Methods: Data were collected via parent-report a sub-sample of the Japan Environment and Children's Study (JECS) including 3728 children born 2011-2014 in Kochi prefecture. NDPs were assessed biannually between 0.5 and 3 years of age with the Ages and Stages Questionnaire-3, at age 2.5 years with the ESSENCE-Q, and at age 1 and 3 years via parent-reported clinical diagnoses. ARFID was identified cross-sectionally (at age 4-7 years) using a newly developed screening tool. Logistic regressions were used to test association of (1) a composite early NDP risk score, (2) specific early NDPs, and (3) neurodevelopmental trajectories over time with ARFID. Results: Children in the highest risk percentiles of the NDP risk score had roughly three times higher odds of having suspected ARFID; the absolute risk of later ARFID for children above the 90th percentile was 3.1%. Early NDPs (excluding early This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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ESSENCE‐Q obtained in routine Japanese public child health check‐ups may be a valuable tool in neurodevelopmental screening

Cited by 12 publications

References 26 publications

How Accurately Does the Information on Motor Development Collected During Health Checkups for Infants Predict the Diagnosis of Neurodevelopmental Disorders? – A Bayesian Network Model-Based Study

How Accurately Does the Information on Motor Development Collected During Health Checkups for Infants Predict the Diagnosis of Neurodevelopmental Disorders? – A Bayesian Network Model-Based Study

The ESSENCE-Questionnaire for Neurodevelopmental Problems – A Swedish School-Based Validation Study in 11-Year-Old Children

Early neurodevelopmental problems and risk for avoidant/restrictive food intake disorder (ARFID) in 4‐7‐year‐old children: A Japanese birth cohort study

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