Essential actions of melatonin in protecting the ovary from oxidative damage

Cruz, María; Leal, Cláudia Lima Verde; Cruz, Jurandir Ferreira da; Tan, Dun Xian; Reíter, Russel J.

doi:10.1016/j.theriogenology.2014.07.011

Cited by 93 publications

(66 citation statements)

References 93 publications

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“…Further, it have been also described that melatonin, another recognized endogenous antioxidant, counteracted the damage of the testis and spermatogenesis in rats subjected to ICH [53]. However, results of our group showed that melatonin had no protective effect in testis and epididymis damaged, despite its amphiphilic nature, and its action of ROS scavenger [54,55].…”

Section: Reproductive Responses and Treatmentmentioning

confidence: 54%

Pharmacological approaches in either intermittent or permanent hypoxia: A tale of two exposures

Herrera

Farías

Ebensperger

et al. 2015

Pharmacological Research

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Section: Reproductive Responses and Treatmentmentioning

confidence: 54%

Pharmacological approaches in either intermittent or permanent hypoxia: A tale of two exposures

Herrera

Farías

Ebensperger

et al. 2015

Pharmacological Research

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“…This feature makes it an effective antioxidant, resulting in protections embryos of macromolecules against ROS [74,120]. In mammalian oocytes, melatonin can prevent damage generated by hypochlorous acid (HOCl) on spindle microtubules and chromosome alterations in metaphase-II mouse oocytes [121], upregulate MnSOD [90,122] and Cu - ZnSOD transcripts in cumulus cells [90], decrease ROS levels in oocytes [90], suppress Bax protein expression and decrease the Bax/Bcl-2 ratio in the ovaries [122], and prevent DNA damage [123] and nuclear fragmentation in cumulus cells [90].…”

Section: Melatonin Modulates Oxidative Stress On Gametes and In VImentioning

confidence: 99%

Melatonin Scavenger Properties against Oxidative and Nitrosative Stress: Impact on Gamete Handling and In Vitro Embryo Production in Humans and Other Mammals

Loren

Sánchez

Arias

et al. 2017

IJMS

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Oxidative and nitrosative stress are common problems when handling gametes in vitro. In vitro development in mammalian embryos is highly affected by culture conditions, especially by reactive oxygen species (ROS) and reactive nitrogen species (RNS), because their absence or overproduction causes embryo arrest and changes in gene expression. Melatonin in gamete co-incubation during in vitro fertilization (IVF) has deleterious or positive effects, depending on the concentration used in the culture medium, demonstrating the delicate balance between antioxidant and pro-oxidant activity. Further research is needed to better understand the possible impact of melatonin on the different IVP steps in humans and other mammals, especially in seasonal breeds where this neuro-hormone system highly regulates its reproduction physiology.

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“…The ability of melatonin to pass the biological barriers due to its amphiphilic nature makes it an effective antioxidant for protecting macromolecules against ROS [65,113]. In mammalian oocytes, melatonin can prevents the damage generated by hypochlorous acid (HOCl) on spindle microtubule and chromosome alteration in metaphase-II mouse oocytes [114], it can upregulates MnSOD [77,115] and Cu-ZnSOD transcripts in cumulus cells [77], it decreases ROS levels in oocytes [77], it can suppress Bax protein expression and decreases Bax/Bcl-2 ratio in ovaries [115], prevents DNA damage [116] and decreases nuclear fragmentation in cumulus cells [77].…”

Section: Melatonin Modulates Oxidative Stress On Gametes and In Vitromentioning

confidence: 99%

Melatonin Scavenger Properties against Oxidative and Nitrosative Stress: Impact on <em>In Vitro</em> Embryo Production in Mammals

Loren¹,

Sánchez²,

Arias³

et al. 2017

Preprint

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Oxidative and nitrosative stress are a common problem when manipulating gametes in vitro. In vitro development in mammalian embryos is highly affected by culture conditions, especially by reactive oxygen species (ROS) and reactive nitrogen species (RNS), because its absence or over production causes embryo arrest and changes in gene expression. Melatonin in gamete co-incubation during IVF has deleterious or positive effects depending on the concentration used in culture medium, demonstrating the delicate balance that must exist between antioxidant and pro-oxidant activity. Further research is needed to better understand the possible impact of melatonin on the different IVP steps in domestic animals, especially in seasonal breeds where this neuro-hormone system highly regulates its reproduction physiology.

show abstract

Essential actions of melatonin in protecting the ovary from oxidative damage

Cited by 93 publications

References 93 publications

Pharmacological approaches in either intermittent or permanent hypoxia: A tale of two exposures

Pharmacological approaches in either intermittent or permanent hypoxia: A tale of two exposures

Melatonin Scavenger Properties against Oxidative and Nitrosative Stress: Impact on Gamete Handling and In Vitro Embryo Production in Humans and Other Mammals

Melatonin Scavenger Properties against Oxidative and Nitrosative Stress: Impact on <em>In Vitro</em> Embryo Production in Mammals

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