Essential and toxic element concentrations in blood and urine and their associations with diet: Results from a Norwegian population study including high-consumers of seafood and game

Birgisdóttir, Bryndís Eva; Knutsen, Helle Katrine; Haugen, Margaretha; Gjelstad, I.M.; Jenssen, Marthe Torunn Solhaug; Ellingsen, Dag G.; Thomassen, Yngvar; Alexander, Jan; Meltzer, Helle Margrete; Brantsæter, Anne Lise

doi:10.1016/j.scitotenv.2013.06.078

Cited by 107 publications

(77 citation statements)

References 50 publications

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“…Several studies have provided range values for toxic and essential elements in urine (Birgisdottir et al 2013;Fréry et al 2011;Hao et al 2015;Heitland and Koster 2006;Hoet et al 2013;Morton et al 2014;NHANES 2013). By comparing range values obtained in this study with those previously reported (Birgisdottir et al 2013;Fréry et al 2011;Hao et al 2015;Heitland and Koster 2006;Hoet et al 2013;Morton et al 2014;NHANES 2013), we found that many elements (e.g., Cu, Mo, Ni, Pb, Sb, Sn, Co and Tl) are highly comparable with the literature (Table 3). Nevertheless, for some contaminant such as Cd and As we can notice significant differences with previously reported values (Table 3).…”

Section: Discussionsupporting

confidence: 84%

Evaluation of Seasonal Variability of Toxic and Essential Elements in Urine Analyzed by Inductively Coupled Plasma Mass Spectrometry

et al. 2016

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Human exposure to elements is a process difficult to control and monitor. Studies on this topic usually rely on single spot urine sample to assess exposure, with the risk of ignoring variability over a longer period. In this work, we measured the urinary excretion of toxic and essential elements during 1 year with the overall goal of exploring the variability caused by seasonality on their concentration. Seven participants were recruited, and first morning urines were collected three times for each season, during November, January, April and July. Participants followed the same balanced diet during the week of collection. We then monitored nineteen essential and toxic elements in urines by inductively coupled plasma mass spectrometry. Unsupervised multivariate statistical analysis separated samples collected during summer from the ones collected during other seasons. Twelve elements had a significant seasonal variation (ANOVA test, p \ 0.05) and their levels resulted increased during summer. These elements were both contaminants, such as Ni, Hg, Cd and Tl, and essential elements such as Se and Cu. However, none of these elements was detected at toxic concentration. In this study, we point out for the first time the variability of urine element concentration due to seasonality and we propose that the season of collection should be considered when providing urinary reference values of elements.

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Section: Discussionsupporting

confidence: 84%

Evaluation of Seasonal Variability of Toxic and Essential Elements in Urine Analyzed by Inductively Coupled Plasma Mass Spectrometry

et al. 2016

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“…In contrast, consumption of all wine types under the high exposure scenario increased the modelled BLL by 2.15 μg/dL, which exceeded background BLL (Table 4). This finding agrees with previous research which suggests that wine consumption could be an important source of Pb exposure among certain wine consumers (Elinder et al 1988;Birgisdottir et al 2013;Tagne-Fotso et al 2016).…”

Section: Risk Associated With Pb In Winesupporting

confidence: 93%

A human health risk assessment of lead (Pb) ingestion among adult wine consumers

2017

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Background: Recent concerns have been raised regarding heavy metal content in wine and its potential health implications. The goal of this study was to determine if lead (Pb) intake poses a health risk among adult consumers of wine. This was achieved by performing a literature review of studies reporting Pb concentration in United States and international wines, determining adult wine consumption rates in the United States using NHANES dietary survey data, utilizing the U.S. EPA's Adult Lead Methodology (ALM) model to estimate adult blood lead levels (BLLs) from wine consumption under various exposure scenarios, and comparing modeled BLLs to guidance values. Models were stratified by average exposure (mean wine Pb concentration) and high exposure (95 th percentile wine Pb concentration) scenarios. Results: Lead concentration data was abstracted from a total of 31 studies, including wine from 18 countries for a total of 472 wine samples. The mean Pb content of international red and white wines were 33.9 μg/L (n = 282) and 35.7 μg/L (n = 118), respectively, while the mean Pb content of domestic red wine was 4.4 μg/L (n = 61). All modelled BLLs were below the Center for Disease Control (CDC) BLL guidance value of 5 μg/dL. Assuming a mean baseline BLL, an individual was required to drink 10.4 glasses of wine per day (all wine types) under the average exposure scenario and 3.7 glasses of wine per day (all wine types) under the high exposure scenario in order to elevate their BLL to the guidance value of 5 μg/dL. When stratified by region, a minimum of approximately 24 glasses of wine from the United States per day was required to raise adult BLLs to the 5 μg/dL guidance value. Conclusions: Overall, findings suggest that Pb content in wine does not pose a health risk to adult wine consumers.

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“…Birgisdóttir et al (2013) found that seafood intake was associated with a PCA-generated factor that included iodine (I), Se, As and Hg. Similarly, Kvalem et al (2009) observed four distinct food factors linking intake of fish liver and seagull eggs to blood concentrations of dioxins and PCBs.…”

Section: Introductionmentioning

confidence: 99%

“…Cd concentrations vary in foods, but fibre-rich foods like cereals (especially rice), vegetables and shellfish contribute to Cd intake (Vahter et al, 2007;Birgisdóttir et al, 2013). Bjermo et al (2013) have demonstrated meat intake to be inversely related to blood Cd concentrations.…”

Section: Introductionmentioning

confidence: 99%

The Northern Norway Mother-and-Child Contaminant Cohort (MISA) Study: PCA analyses of environmental contaminants in maternal sera and dietary intake in early pregnancy

Veyhe

Hofoss

Hansen

et al. 2015

International Journal of Hygiene and Environmental Health

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Essential and toxic element concentrations in blood and urine and their associations with diet: Results from a Norwegian population study including high-consumers of seafood and game

Cited by 107 publications

References 50 publications

Evaluation of Seasonal Variability of Toxic and Essential Elements in Urine Analyzed by Inductively Coupled Plasma Mass Spectrometry

Evaluation of Seasonal Variability of Toxic and Essential Elements in Urine Analyzed by Inductively Coupled Plasma Mass Spectrometry

A human health risk assessment of lead (Pb) ingestion among adult wine consumers

The Northern Norway Mother-and-Child Contaminant Cohort (MISA) Study: PCA analyses of environmental contaminants in maternal sera and dietary intake in early pregnancy

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