Essential Fatty Acids Influence Survival in Sepsis

Ja, Johnson; Ja, Griswold; Ff, Muakkassa

doi:10.1097/00005373-199307000-00020

Cited by 45 publications

(3 citation statements)

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“…They also contribute to a decrease in the production of leukotriene B 4 and prostaglandin E 2 , which play important roles in inflammation and pain. Mitigating pain and inflammation will improve recovery time and accelerate the healing process [68] [69]. Omega-3 fatty acids decrease muscle loss in dogs with chronic heart failure and improve appetite [70].…”

Section: Fatty Acidsmentioning

confidence: 99%

Nutritional Support of Dogs and Cats after Surgery or Illness

Corbee¹,

Kerkhoven²

2014

OJVM

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Nutritional support early during the postoperative period or after onset of illness decreases the mortality rate and shortens the duration of hospitalization of dogs and cats. The preferred feeding route is dependent on the condition of the patient. If there are no contraindications, every patient must receive nutritional support, at least consistent with the resting energy requirement (RER). Several nutrients may be beneficial during healing and recovery from illness or surgery, but further research is needed to empirically certify the effects of these nutrients in critically ill patients.

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Section: Fatty Acidsmentioning

confidence: 99%

Nutritional Support of Dogs and Cats after Surgery or Illness

Corbee¹,

Kerkhoven²

2014

OJVM

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“…In traumatized and surgical patients an enteral diet containing n-3 fatty acids significantly reduced infectious complications and septic events (Braga et al 1996;Kudsk et al 1996;Senkal et al 1997). Enhanced survival and reduced lung failure after enteral or parenteral administration of n-3 PUFAs was observed in experimental models of sepsis (Barton et al 1991;Grimminger et al 1997;Johnson et al 1993). Interestingly, by incorporation into various membrane (phospho)-lipid pools, n-3 PUFAs may affect lipid-signaling events in different cell types (Chakrabarti et al 1997;Diep et al 2000).…”

Section: Tlrs In Signaling and Immunonutrition: Clinical Aspectsmentioning

confidence: 99%

Innate Immunity Signaling Pathways: Links between Immunonutrition and Responses to Sepsis

Słotwiński

Słotwińska

Kędziora

et al. 2011

Arch. Immunol. Ther. Exp.

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Septic infections in patients treated in intensive care units show the highest mortality rates. Despite advances in treatment methods, there is still no therapy available to efficiently reduce the excessive inflammatory response, which can increase the risk of multiple organ failure. One of the ways to discover new, more efficient treatment methods involves regulating the mechanisms of inflammatory response to a massive infection. Toll-like receptors (TLRs) that recognize pathogen-associated molecular patterns play a significant role in innate antibacterial and inflammatory responses. The regulatory impact of immunonutrition on TLR expression in septic patients seems to be a promising research direction. This paper presents the main mechanisms for the innate immune response to lipopolysaccharide, based on the research results for both TLR-dependent and independent signaling pathways. Special emphasis was put on the research results for the TLR-dependent immune response and the anti-bacterial/anti-inflammatory response after applying immunonutrition with increased concentrations of glutamine and unsaturated fatty acids.

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“…Neben etablierten Therapieprinzipien, wie Fokussanierung,Antibiotika und hämody-namische Stabilisierung, wurden einhergehend mit den zunehmenden Erkenntnissen über die immunologischen Imbalancen in der Sepsis neue vorwiegend immunmodulatorische Therapieverfahren klinisch evaluiert [18]. Sowohl im Rahmen dieser Untersuchungen [41,61] als auch in Arbeiten zum Stressstoffwechsel [72] sowie zur Inzidenz kardiovaskulärer Erkrankungen [12] erwiesen sich einzelne Ernährungskomponenten zunächst experimentell als auch in vivo als potente Modulatoren protektiver immunologischer Reaktionen. Ebenfalls wuchs in den letzten Jahren vor dem Hintergrund der intestinalen Translokationsmechanismen das Wissen um die Notwendigkeit einer funktionierenden intestinalen Mukosa-Homöostase.…”

Section: Klinische Implikationenunclassified

Stellenwert immunnutritiver enteraler Ernährung in der operativen Intensivmedizin

et al. 2002

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Since imbalances in the immune system of the critically ill patient have been demonstrated, the role of the gastrointestinal tract for the pathogenesis of multiple organ failure has been a focus of research in intensive care medicine. Particularly, the integrity of the intestinal barrier function has been studied experimentally and clinically. The enormous number of gram-negative bacteria up to 10(11)/ml intestinal liquid inducing the release of significant amounts of endotoxin, is considered to be a vital threat to the intensive care unit (ICU) patient. Acute failure of the intestinal barrier following various types of severe shock or following parenteral nutrition inducing atrophy of intestinal mucosa may lead to multiple organ dysfunction. Maintenance of hemodynamic stability is a mainstay of therapy of the critically ill. In addition, the intestinal integrity can be preserved by the early onset of enteral nutrition. Moreover, recent concepts of enteral nutrition using immunomodulating nutrients like omega-3-fatty acids, glutamine, arginine, and nucleotides are under clinical evaluation.

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Essential Fatty Acids Influence Survival in Sepsis

Cited by 45 publications

References 0 publications

Nutritional Support of Dogs and Cats after Surgery or Illness

Nutritional Support of Dogs and Cats after Surgery or Illness

Innate Immunity Signaling Pathways: Links between Immunonutrition and Responses to Sepsis

Stellenwert immunnutritiver enteraler Ernährung in der operativen Intensivmedizin

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