Essential hypertension in patients exposed to high-arsenic exposed areas in western China: Genetic susceptibility and urinary arsenic metabolism characteristics

Cheng, Jin Q.; Li, Yuanyuan; He, Qian; Luo, Lanrong; Zhang, Yanting; Gao, Yanhui; Feng, Huiyun; Zhao, Liyun; Wei, Wei; Fu, Shanlin; Sun, Dianjun

doi:10.1016/j.jtemb.2021.126778

Cited by 10 publications

(7 citation statements)

References 64 publications

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“…The SNP typing technique has been reported in the study of Cheng et al. ( 27 ). 5% of duplicate DNA samples were analyzed for quality control, with consistence in more than 99% of the samples.…”

Section: Methodsmentioning

confidence: 99%

“…The SNPs were genotyped by SNPscan ™ multiplex SNP typing kit (Cat#: G0104K, Genesky Biotechnologies Inc. Shanghai, China), provided by Shanghai Tianhao Biotechnology Co., Ltd., China. The SNP typing technique has been reported in the study of Cheng et al (27). 5% of duplicate DNA samples were analyzed for quality control, with consistence in more than 99% of the samples.…”

Section: Snps Selection and Gene Sequencingmentioning

confidence: 99%

“…We observed that compared with the non-PSD group, PSD group showed a higher proportion of female (40.80% vs. 20.37%, p = 0.024), lower years of education (9 [6-12] vs. 12 [9][10][11][12][13][14][15][16]; p = 0.044), higher stroke severity (NIHSS score: 5 [1.5-8.5] vs. 2 [1-4.5]; p = 0.046), worse cognitive function (MMSE score: 24 [22][23][24][25][26][27] vs. 27 [23-29]; p = 0.027) and lower monocyte count (0.50 [0.35-0.60] vs. 0.50 [0.48-0.70]; p = 0.007). BMI, pulmonary infection, medicines (antibiotic, statin and antiplatelet agents), vascular risk factors (hypertension, diabetes mellitus, heart disease, hyperlipidemia, smoking, drinking and previous stroke), stroke type including TOAST classification, stroke hemisphere, stroke location, the times from stroke onset to chest CT scan and to the blood sample collection, complete blood count parameters (leukocyte, neutrophil, lymphocyte and platelet counts, platelet-tolymphocyte ratio, neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio), and SV did not show any significantly association with PSD status.…”

Section: Characteristics Of Psd and Non-psd Patientsmentioning

confidence: 99%

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The potential risk factors of early-onset post-stroke depression from immuno-inflammatory perspective

et al. 2022

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BackgroundMounting evidence strongly uncovered that peripheral immuno-inflammatory response induced by acute stroke is associated with the appearance of post-stroke depression (PSD), but the mechanism remains unclear.Methods103 stroke patients were assessed at 2 weeks after onset using Diagnostic and Statistical Manual of Mental Disorders, 5th edition and then divided into PSD and non-PSD groups. Polymorphisms of inflammatory molecules (interleukin [IL]-1β, IL-6, IL-10, IL-18, tumor necrosis factor-α [TNF-α], interferon-γ [IFN-γ] and C-reactive protein [CRP]), complete blood count parameters, splenic attenuation (SA) and splenic volume (SV) on unenhanced chest computed tomography, demographic and other clinical characteristics were obtained. Binary logistic regression model was used to analyze the associations between inflammation-related factors and the occurrence of PSD at 2 weeks after stroke.Results49 patients were diagnosed with PSD at 2 weeks after onset (early-onset PSD). The C/T genotypes of CRP rs2794520 and rs1205 were less in PSD group than non-PSD group (both adjusted odds ratio = 3.364; 95%CI: 1.039-10.898; p = 0.043). For CRP rs3091244, the frequency of G allele was higher (80.61% vs. 13.89%) while the frequency of A allele was lower (6.12% vs. 71.30%) in PSD patients than non-PSD patients (χ2 = 104.380; p<0.001). SA of PSD patients was lower than that of non-PSD patients in the presence of CRP rs2794520 C/T genotype and rs1205 C/T genotype (both t = 2.122; p = 0.039). Peripheral monocyte count was less in PSD group than non-PSD group (adjusted odds ratio = 0.057; 95%CI: 0.005-0.686; p = 0.024).ConclusionsCRP polymorphisms, SA based on CRP genotype, and peripheral monocytes are associated with the risk of early-onset PSD, suggesting peripheral immuno-inflammatory activities elicited by stroke in its aetiology.

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Section: Methodsmentioning

confidence: 99%

Section: Snps Selection and Gene Sequencingmentioning

confidence: 99%

Section: Characteristics Of Psd and Non-psd Patientsmentioning

confidence: 99%

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The potential risk factors of early-onset post-stroke depression from immuno-inflammatory perspective

et al. 2022

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“…We identified 15 SNPs in genes of IDO (IDO1 and IDO2) and its inducers (including IFN-g, TNF-a, IL-1b, IL-2 and IL-6) selected from previous literature associated with PSD or depression or stroke, with a minor allele frequency > 0.05 indexed in the Chinese Han population dataset of a genetic database (http://www.ensembl.org). Each SNP was genotyped using SNPscan ™ multiple SNP genotyping technology (22) unaware of the sample status.…”

Section: Gene Polymorphism Selection and Genotypingmentioning

confidence: 99%

The role of indoleamine 2,3-dioxygenase 1 in early-onset post-stroke depression

et al. 2023

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BackgroundThe immune-inflammatory response has been widely considered to be involved in the pathogenesis of post-stroke depression (PSD), but there is ambiguity about the mechanism underlying such association.MethodsAccording to Diagnostic and Statistical Manual of Mental Disorders (5th edition), depressive symptoms were assessed at 2 weeks after stroke onset. 15 single nucleotide polymorphisms (SNPs) in genes of indoleamine 2,3-dioxygenase (IDO, including IDO1 and IDO2) and its inducers (including pro-inflammatory cytokines interferon [IFN]-γ, tumor necrosis factor [TNF]-α, interleukin [IL]-1β, IL-2 and IL-6) were genotyped using SNPscan™ technology, and serum IDO1 levels were detected by double-antibody sandwich enzyme-linked immune-sorbent assay.ResultsFifty-nine patients (31.72%) were diagnosed with depression at 2 weeks after stroke onset (early-onset PSD). The IDO1 rs9657182 T/T genotype was independently associated with early-onset PSD (adjusted odds ratio [OR] = 3.008, 95% confidence interval [CI] 1.157-7.822, p = 0.024) and the frequency of rs9657182 T allele was significantly higher in patients with PSD than that in patients with non-PSD (χ2 = 4.355, p = 0.037), but these results did not reach the Bonferroni significance threshold (p > 0.003). Serum IDO1 levels were also independently linked to early-onset PSD (adjusted OR = 1.071, 95% CI 1.002-1.145, p = 0.044) and patients with PSD had higher serum IDO1 levels than patients with non-PSD in the presence of the rs9657182 T allele but not homozygous C allele (t = -2.046, p = 0.043). Stroke patients with the TNF-α rs361525 G/G genotype had higher serum IDO1 levels compared to those with the G/A genotype (Z = -2.451, p = 0.014).ConclusionsOur findings provided evidence that IDO1 gene polymorphisms and protein levels were involved in the development of early-onset PSD and TNF-α polymorphism was associated with IDO1 levels, supporting that IDO1 which underlie strongly regulation by cytokines may be a specific pathway for the involvement of immune-inflammatory mechanism in the pathophysiology of PSD.

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“…Hypertension in patients exposed to high As areas in western China has been investigated. 74 The study focused on genetic susceptibility and urinary As metabolism characteristics. A case-control study was conducted involving individuals exposed to high As levels (the As content in the pressurised well water was up to 510 μg L −1 , and that in the mechanical well water was 167 μg L −1 ) in two adjacent high-As areas in W China.…”

Section: Elemental Speciation Analysismentioning

confidence: 99%