2010
DOI: 10.1074/jbc.m110.130575
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Essential in Vivo Roles of the C-type Lectin Receptor CLEC-2

Abstract: CLEC-2 has been described recently as playing crucial roles inClec-2 ؉/؉ embryos, we were able to demonstrate that CLEC-2 is involved in thrombus stabilization in vitro and in vivo, possibly through homophilic interactions without apparent increase in bleeding tendency. We propose that CLEC-2 could be an ideal novel target protein for an anti-platelet drug, which inhibits pathological thrombus formation but not physiological hemostasis.

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Cited by 243 publications
(119 citation statements)
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References 34 publications
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“…25-27 DUSP3 was dispensable for integrin α IIb β 3 outside-in signaling, as indicated by unaltered fibrin clot retraction (data not shown). Dusp3 -KO mice exhibited levels of thrombus formation comparable to the previously reported GPVI-KO/FcRγ-KO 28-30 CLEC-2-KO, 31 CLEC-2-depleted, 26 GPVI-depleted, 32 and CLEC-2/GPVI-depleted mice. 27 Similar to our findings in DUSP3-deficient mice, GPVI-KO and CLEC-2-KO mice do not exhibit prolonged bleeding time.…”
Section: Discussionsupporting
confidence: 84%
See 1 more Smart Citation
“…25-27 DUSP3 was dispensable for integrin α IIb β 3 outside-in signaling, as indicated by unaltered fibrin clot retraction (data not shown). Dusp3 -KO mice exhibited levels of thrombus formation comparable to the previously reported GPVI-KO/FcRγ-KO 28-30 CLEC-2-KO, 31 CLEC-2-depleted, 26 GPVI-depleted, 32 and CLEC-2/GPVI-depleted mice. 27 Similar to our findings in DUSP3-deficient mice, GPVI-KO and CLEC-2-KO mice do not exhibit prolonged bleeding time.…”
Section: Discussionsupporting
confidence: 84%
“…27 Similar to our findings in DUSP3-deficient mice, GPVI-KO and CLEC-2-KO mice do not exhibit prolonged bleeding time. 28, 31, 33 DUSP3-deficient mice were also protected against pulmonary thromboembolism induced by a mixture of collagen and epinephrine, similar to GPVI-KO mice. 33 …”
Section: Discussionmentioning
confidence: 76%
“…This also phenocopies the effects observed upon genetic deletion of Prospero homeobox 1 ( prox-1 ) [36], Src homology domain-containing leukocyte protein-76 ( slp-76) [37] or C-type lectin-like receptor 2 ( clec-2 ) [38]. All show impaired lymphatic vessel development and die in utero with severe edema and hemorrhages.…”
Section: Resultsmentioning
confidence: 72%
“…This newly recognized role for platelets in lymphatic development is based on murine models and is important because organization of the lymphatic system, lymphocyte, and other cellular trafficking via lymphatics and immune and inflammatory responses are intimately intertwined [272]. CLEC-2 is also required for stable platelet aggregation and thrombus stabilization in vivo and in vitro based on studies of genetically altered mice [269]. …”
Section: Platelets In Adaptive Immune Responsesmentioning
confidence: 99%