Let M be a compact, connected, orientable, hyperbolic 3-manifold whose boundary is a torus and which contains an essential closed surface S. It is conjectured that 5 is an upper bound for the distance between two slopes on ∂M whose associated fillings are not hyperbolic manifolds. In this paper we verify the conjecture when the first Betti number of M is at least 2 by showing that given a pseudo-Anosov mapping class f of a surface and an essential simple closed curve γ in the surface, then 5 is an upper bound for the diameter of the set of integers n for which the composition of f with the n th power of a Dehn twist along γ is not pseudo-Anosov. This sharpens an inequality of Albert Fathi. For large manifolds M of first Betti number 1 we obtain partial results. SetA singular slope for S is a slope r 0 ∈ C(S) such that any other slope in C(S) is at most distance 1 from r 0 . We prove that the distance between two exceptional filling slopes is at most 5 if either (i) there is a closed essential surface S in M with C(S) finite, or (ii) there are singular slopes r 1 = r 2 for closed essential surfaces S 1 , S 2 in M .