Essential Metal Related Metabolic Disorders

Mawani, Yasmin; Orvig, Chris

doi:10.1002/9783527633104.ch11

Cited by 3 publications

(1 citation statement)

References 137 publications

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“…For the huge construction company established by Osama bin Laden's father in 1931 -now one of the largest of global construction corporations -is both a key investor and main constructor in the building of Jeddah's Kingdom Tower. 60 There is also irrefutable evidence that various members of the Saudi royal family -along with their litany of Wahhabist religious clerics -were the principal financiers of al-Qaeda and the Taliban in the 1990s, in the run-up to the 2001 attacks as part of their long-standing support for Islamist jihad across the world. It has been estimated that between 1921 and 1991 Saudi royal and religious elites spent between $100 and $200 billion exporting the Wahhabist ideology that is at the root of the Islamist violence of the Taliban, al-Qaeda and ISIS.…”

Section: Spike In the Sandmentioning

confidence: 99%

Re-centring the City

2019

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Section: Spike In the Sandmentioning

confidence: 99%

Re-centring the City

2019

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Stable Isotope Composition of Metal Elements in Biological Samples as Tracers for Element Metabolism

Tanaka

Hirata

2018

ANAL. SCI.

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Stable isotope composition varies due to different reactivity or mobility among the isotopes. Various pioneering studies revealed that isotope fractionation is common for many elements, and it is now widely recognized that the stable isotope compositions of biometals can be used as new tracers for element metabolism. In this review, we summarize the recently published isotope compositions of iron (Fe), copper (Cu), zinc (Zn), and calcium (Ca) in various biological samples, including tissues from plants, animals, and humans. Discussions were carried out with respect to age, sex, organ, and the presence or absence of particular diseases for animals and humans. For Fe and Cu isotopes, changes in oxidation states generate large isotopic fractionation through the metabolism of those elements. Isotope composition of Zn greatly fractionates among tissues even without changes in oxidation state. Isotopic composition of Ca is a powerful tracer for the metabolism of Ca in bones. The review results suggest that the stable isotope compositions of the biometals can be used as effective markers for diagnostics of various kinds of diseases related to metabolic disorders.

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Stable Isotope Metallomics

Tanaka

Ogra

Mikuni-Takagaki

et al. 2019

J. Mass Spectrom. Soc. Jpn.

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In this paper, we describe both the analytical procedures of isotope ratio measurements and recent progresses in the stable isotope studies of biometals, including iron Fe and calcium Ca e mass spectrometer utilizing atmospheric pressure plasma ion source ICP-MS is the most versatile technique for the stable isotope analysis of heavy elements, and employed in most of the studies. e analytical procedures for minimizing the in uence of both mass spectrometric and non-mass spectrometric interferences are quite important for the precise isotopic analysis of Fe and Ca. For Fe isotopes, changes in oxidation states generate large isotopic fractionation through the metabolism of Fe, and the isotope ratio data of Fe can provide information about long-term nutritional status of Fe. For Ca, isotopic ratios of Ca can become a powerful tracer for evaluating the metabolism of Ca in bones. e data presented here revealed that the stable isotope compositions of the biometals can be used as an e ective marker for both diagnostics of various diseases related to metabolic disorder and evaluation of nutritional status of both wild and ancient animals.

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Essential Metal Related Metabolic Disorders

Cited by 3 publications

References 137 publications

Re-centring the City

Re-centring the City

Stable Isotope Composition of Metal Elements in Biological Samples as Tracers for Element Metabolism

Stable Isotope Metallomics

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