Essential mineral and trace element nutriture methodology

Aggett, Peter; James, W. P. T.; Ralph, Ann; Reid, David M.; Herçberg, Serge; Galán, Pilar; Dhur, Agnès; Testolin, G.; Ciappellano, Salvatore; Arthur, J. R.

doi:10.1007/978-1-4899-6946-0_8

Cited by 2 publications

(1 citation statement)

References 158 publications

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“…The authors established reference ranges for serum concentrations of copper and zinc for the subjects in a previous study (11). They showed a normal distribution, were sex-specific, and corroborated with values reported for populations in the West (12)(13)(14). Apart from LDL-C, the lipid indices like the microminerals were sexspecific.…”

Section: Discussionsupporting

confidence: 76%

Serum microminerals and the indices of lipid metabolism in an apparently healthy population

Abiaka

Olusi

Al-Awadhi

2003

Clinical Laboratory Analysis

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Serum copper and zinc concentrations were measured in 560 apparently healthy Kuwaitis (238 males and 322 females) aged 15-80 years to assess micromineral effect on the indices of lipid metabolism. Following the recommended guidelines of the European Atherosclerosis Society (EAS) and the National Cholesterol Education Program Expert Panel (NCEPEP), the incidence of dyslipidemia was assessed from enzymatic assay data of triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) concentrations. Males had significantly lower TC (P=0.029) and HDL-C (P<0.0001) levels than females, while TG were significantly (P=0.023) lower in females. The prevalence of hypercholesterolemia, hypertriglyceridemia, elevated LDL-C, and low HDL-C levels were 35, 30, 22, and 13%, respectively. Copper did not correlate with zinc (r = -0.067, P = 0.135) but was positively associated with TC (r=0.196, P<0.0001), LDL-C (r=0.134, P = 0.003), TG (r = 0.092, P=0.039), and age (r=0.281, P<0.0001). It is concluded that unlike in animal studies, copper excess in humans is associated with hyperlipidemia and therefore will predispose to atherosclerosis.

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Section: Discussionsupporting

confidence: 76%

Serum microminerals and the indices of lipid metabolism in an apparently healthy population

Abiaka

Olusi

Al-Awadhi

2003

Clinical Laboratory Analysis

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Reference Ranges of Copper and Zinc and the Prevalence of Their Deficiencies in an Arab Population Aged 15-80 Years

Abiaka

Olusi

Al-Awadhi

2003

BTER

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Serum concentrations of copper and zinc were measured by flame atomic absorption spectrophotometry in 560 Kuwaitis aged from 15 to 80 yr who were in apparent good health to establish reference ranges and determine the prevalence of the deficiency of the trace metals. Zinc/copper ratios were derived by calculation. Because the mean +/- SD (microM) for copper in females (24.9 +/- 7) was significantly higher (p<0.0001) than in males (21.0 +/- 5.8) and vice versa for zinc (17.0 +/- 3.5 [males] vs 15.5 +/- 3.4 [females]) and zinc/copper ratios (0.87 +/- 0.28 [males] vs 0.67 +/- 0.27 [females]), gender-specific reference ranges were established in addition to reference ranges for the total population. The reference range for zinc was closer to those reported for other populations than was copper. Body mass index (BMI) and copper values were lower and the zinc/copper ratio was higher in the young (15-24 yr) compared to the older subjects. Copper concentrations were positively associated with BMI values (r=0.302, p<0.0001). Smokers had significantly lower (p=0.011) BMI than nonsmokers. The prevalence of copper and zinc deficiency, 0.36% and 0.53%, respectively, was low. Generally, the values for serum copper and zinc obtained for the Kuwaiti population studied suggest adequate dietary intake of the trace metals.

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Essential mineral and trace element nutriture methodology

Cited by 2 publications

References 158 publications

Serum microminerals and the indices of lipid metabolism in an apparently healthy population

Serum microminerals and the indices of lipid metabolism in an apparently healthy population

Reference Ranges of Copper and Zinc and the Prevalence of Their Deficiencies in an Arab Population Aged 15-80 Years

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