Essential oil characterization of Ocimum basilicum and Syzygium aromaticum free and complexed with β-cyclodextrin. Determination of its antioxidant, antimicrobial, and antitumoral activities

Miyoshi, Juliana Harumi; Castro, Juliana Cristina; Fenelon, Vanderson Carvalho; Garcia, Francielle P.; Nakamura, Celso V.; Nogueira, Ana Cláudia Fernandes; Ueda-Nakamura, Tânia; Souza, Hâmara Milaneze de; Mangolim, Camila Sampaio; Moura-Costa, Gislaine F.; Matioli, Graciette

doi:10.1007/s10847-021-01107-0

Cited by 16 publications

(8 citation statements)

References 40 publications

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“…Nanotechnology is currently widely used in different areas 1 such as solar energy conversion 2 , catalysis 3 , medicine 4 , and water treatment 5 . Some specific applications of nanotechnology in biotechnology 6 and biomedicine 7 include additives for textile industry 8 , food packaging 9 , 10 , protein immobilization 11 , and development of optoelectronic materials 12 .…”

Section: Introductionmentioning

confidence: 99%

Biogeneration of silver nanoparticles from Cuphea procumbens for biomedical and environmental applications

González-Pedroza

Benítez

Navarro-Marchal

et al. 2023

Sci Rep

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Nanotechnology is one of the most important and relevant disciplines today due to the specific electrical, optical, magnetic, chemical, mechanical and biomedical properties of nanoparticles. In the present study we demonstrate the efficacy of Cuphea procumbens to biogenerate silver nanoparticles (AgNPs) with antibacterial and antitumor activity. These nanoparticles were synthesized using the aqueous extract of C. procumbens as reducing agent and silver nitrate as oxidizing agent. The Transmission Electron Microscopy demonstrated that the biogenic AgNPs were predominantly quasi-spherical with an average particle size of 23.45 nm. The surface plasmonic resonance was analyzed by ultraviolet visible spectroscopy (UV–Vis) observing a maximum absorption band at 441 nm and Infrared Spectroscopy (FT IR) was used in order to structurally identify the functional groups of some compounds involved in the formation of nanoparticles. The AgNPs demonstrated to have antibacterial activity against the pathogenic bacteria Escherichia coli and Staphylococcus aureus, identifying the maximum zone of inhibition at the concentration of 0.225 and 0.158 µg/mL respectively. Moreover, compared to the extract, AgNPs exhibited better antitumor activity and higher therapeutic index (TI) against several tumor cell lines such as human breast carcinoma MCF-7 (IC50 of 2.56 µg/mL, TI of 27.65 µg/mL), MDA-MB-468 (IC50 of 2.25 µg/mL, TI of 31.53 µg/mL), human colon carcinoma HCT-116 (IC50 of 1.38 µg/mL, TI of 51.07 µg/mL) and melanoma A-375 (IC50 of 6.51 µg/mL, TI of 10.89 µg/mL). This fact is of great since it will reduce the side effects derived from the treatment. In addition, AgNPs revealed to have a photocatalytic activity of the dyes congo red (10–3 M) in 5 min and malachite green (10–3 M) in 7 min. Additionally, the degradation percentages were obtained, which were 86.61% for congo red and 82.11% for malachite green. Overall, our results demonstrated for the first time that C. procumbens biogenerated nanoparticles are excellent candidates for several biomedical and environmental applications.

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Section: Introductionmentioning

confidence: 99%

Biogeneration of silver nanoparticles from Cuphea procumbens for biomedical and environmental applications

González-Pedroza

Benítez

Navarro-Marchal

et al. 2023

Sci Rep

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“…It consists of 81–95% phenols (eugenol with about 3% of acetyl eugenol), sesquiterpenes (a- and b-calyophyllenes), and small quantities of esters, alcohols, and ketones [ 24 , 27 , 28 , 29 , 30 , 36 , 41 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ]. The high level of eugenol present in clove oil endows it with intense biological and antimicrobial activity [ 53 ], which is why it was explored here as a stabilizing and reducing agent in the synthesis of AgNPs. Therefore, it is important to develop dental materials with antibacterial activity and better mechanical properties, which could be manufactured and employed in future clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Biogenic Silver Nanoparticles from Syzygium aromaticum against the Five Most Common Microorganisms in the Oral Cavity

et al. 2022

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Syzygium aromaticum (clove) has been used as a dental analgesic, an anesthetic, and a bioreducing and capping agent in the formation of metallic nanoparticles. The main objective of this study was to evaluate the antimicrobial effect in oral microorganisms of biogenic silver nanoparticles (AgNPs) formed with aqueous extract of clove through an ecofriendly method “green synthesis”. The obtained AgNPs were characterized by UV-Vis (ultraviolet-visible spectroscopy), SEM-EDS (scanning electron microscopy–energy dispersive X-ray spectroscopy), TEM (transmission electron microscopy), and ζ potential, while its antimicrobial effect was corroborated against oral Gram-positive and Gram-negative microorganisms, as well as yeast that is commonly present in the oral cavity. The AgNPs showed absorption at 400–500 nm in the UV-Vis spectrum, had an average size of 4–16 nm as observed by the high-resolution transmission electron microscopy (HR-TEM), and were of a crystalline nature and quasi-spherical form. The antimicrobial susceptibility test showed inhibition zones of 2–4 mm in diameter. Our results suggest that AgNPs synthesized with clove can be used as effective growth inhibitors in several oral microorganisms.

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“…oil of Ocimum basilicum from India [23], while the major compound in the essential oil of basil from Vietnam was methyl chavicol [24]. e remarkable differences in the compositions of the essential oils of basil plants are attributable to the effects of geographical parameters, the nature of the soil and irrigation water used, and the season of growth.…”

Section: Discussionmentioning

confidence: 99%

Optimization of GC-MS Method for Analysis of Basil Essential Oils from Algeria: Design of Experiments and Exploratory Pattern Recognition

Slougui

Slama

Boudaoud

et al. 2022

Journal of Chemistry

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An optimization procedure for multistep temperature-programmed capillary gas chromatography was developed for the analysis of basil essential oil. The current study was planned after performing the following three steps: a preliminary chromatographic study, primary parameter screening, and final method optimization by using 23 factorial and Doehlert designs (DOE). The optimized conditions were obtained by using a split ratio of 1 / 2 , a gas flow rate of 1.3 mL/min, and a heating rate of 2°C/min. This set of conditions was later used for the optimization of the final method. The optimal experimental conditions were subsequently obtained by response surface optimization (isotherm duration = 6.2 min and slope = 1.06°C/min). The compositions of essential oils from six varieties of basil (Ocimum B. (1), Ocimum B. purpurescens opal (2), Ocimum B. minimum (3), Ocimum. B. cinnamon (4), Ocimum B. (marcellas) (5), and Ocimum B. Citriodora (6)) grown in four regions of Algeria (Ouargla, south of Algeria (O); Mostaganem, west of Algeria (M); Algiers, north of Algeria (A), and Constantine, east of Algeria (C)) were determined. A statistical study was performed based on hierarchical ascending classification and principal component analysis to elucidate the relationships between the basil varieties, their region of growth, and their essential oil composition. In addition to identifying several chemotypes, such as linalool, linalool/eugenol, linalool acetate, methyl eugenol, methyl chavicol, eugenol, methyl cinnamate E, and geraniol, a new compound, namely, octadecenamide (Z) (oleamide), was detected in the essential oil of Ocimum basilicum L. from Algiers (A1).

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Essential oil characterization of Ocimum basilicum and Syzygium aromaticum free and complexed with β-cyclodextrin. Determination of its antioxidant, antimicrobial, and antitumoral activities

Cited by 16 publications

References 40 publications

Biogeneration of silver nanoparticles from Cuphea procumbens for biomedical and environmental applications

Biogeneration of silver nanoparticles from Cuphea procumbens for biomedical and environmental applications

Antimicrobial Activity of Biogenic Silver Nanoparticles from Syzygium aromaticum against the Five Most Common Microorganisms in the Oral Cavity

Optimization of GC-MS Method for Analysis of Basil Essential Oils from Algeria: Design of Experiments and Exploratory Pattern Recognition

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