Essential Oil Chemical Characterization and Antioxidant Potential of Pulicaria inuloides from the Southwest of Algeria

Fadel, Hamza; Bensaid, Sara-Ouissem; Chalchat, Jean‐Claude; Figuérédo, Gilles; Cartigny, Pierre; Benayache, Fadila; Ghedadba, Nabil; Zerimech, Rania

doi:10.1007/s42250-020-00151-6

Cited by 3 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent phytochemical investigations of P. inuloides have led to the identification of components in the essential oils from aerial parts of the plant [ 25 ] and to the isolation of several polyphenolic and terpenoid constituents, including ent -kaurane diterpenoids, β -sitosterol, daucosterol, and methoxylated flavonols ( 10 , 11 , 13 ) [ 22 , 24 ]. The bioguided fractionation of the P. inuloides root extract yielded 8,9-epoxy-10-isobutyryloxythymyl isobutyrate ( 1 ) as a constituent responsible for the antileishmanial activity of the plant [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…Essential oil from the aerial parts of the plants collected in the Southwest of Algeria has been recently chemically characterized. Δ-Cadinene, α- epi -cadinol, and α-cadinol were identified as major constituents of the analyzed oil [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

“…Polar extracts from P. inuloides , as yet, have been characterized by their total phenolic content, total flavonoid content, antiparasitic, antioxidative, and radical scavenging activity [ 22 , 25 ]. There are no data on the chemical constituents of this part of the plant metabolome.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Constituents of Pulicaria inuloides and Cytotoxic Activities of Two Methoxylated Flavonols

et al. 2023

View full text Add to dashboard Cite

Plants of the genus Pulicaria are known for providing traditional medicines, spices, herbal teas, and insect deterrents. Pulicaria inuloides (Poir.). DC. is one of the less chemically studied species within the genus. Hydroalcoholic extracts from roots and aerial parts of P. inuloides were analyzed using the UHPLC-PAD-MSn technique and revealed the presence of six caffeoylquinic and eleven caffeoylhexaric conjugates together with hydroxykaempferol dimethyl ether and quercetagetin trimethyl ether. Moreover, constituents of chloroform extract from the whole P. inuloides plants were isolated and identified by spectroscopic methods. One new and four known caryophyllene derivatives, three thymol derivatives, and four polymethoxylated flavonols were found in the analyzed extract. The structure of the new compound was established by spectroscopic methods (HRESIMS, 1H NMR, 13C NMR, COSY, HSQC, HMBC, NOESY). The cytotoxicity of 6-Hydroxykaempferol 3,7-dimethyl ether and quercetagetin 3,7,3’-trimethyl ether (chrysosplenol C), which are major flavonols isolated from the plant, were tested on prostate epithelial cells (PNT2), prostate cancer cells (DU145 and PC3), human keratinocytes (HaCaT), and melanoma cells (HTB140 and A375). Both flavonols demonstrated moderate cytotoxic activity against PC3 cells (IC50 = 59.5 µM and 46.6 µM, respectively). The remaining cell lines were less affected (IC50 > 150 µM).

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%