Essential oil composition

Tisserand, Robert; Young, Rodney

doi:10.1016/b978-0-443-06241-4.00002-3

Cited by 51 publications

(78 citation statements)

References 61 publications

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“…Camphor is neurotoxic, and is also toxic to the liver, but the mechanisms are still to be elucidated. It was demonstrated that camphor is oxidized to 5-exo-hydroxyfenchone derivatives in human liver microsomes, and that might contribute to hepatic excretory impairment after administration of REO in the dose of 10 mg/kg [36,37]. Monoterpene α-pinene might also exert toxic effects in high doses.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant activity of rosemary (Rosmarinus officinalis L.) essential oil and its hepatoprotective potential

Rašković

Milanović

Pavlović

et al. 2014

BMC Complement Altern Med

351

188

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BackgroundNatural antioxidant products are increasingly being used to treat various pathological liver conditions considering the role of oxidative stress in their pathogenesis. Rosemary essential oil has already being used as a preservative in food industry due to its antioxidant and antimicrobial activities, but it was shown to possess additional health benefits. The aim of our study was to evaluate the protective effect of rosemary essential oil on carbon tetrachloride - induced liver injury in rats and to explore whether its mechanism of action is associated with modulation of hepatic oxidative status.MethodsChemical composition of isolated rosemary essential oil was determined by gas chromatography and mass spectrometry. Antioxidant activity was determined in vitro using DPPH assay. Activities of enzyme markers of hepatocellular damage in serum and antioxidant enzymes in the liver homogenates were measured using the kinetic spectrophotometric methods.ResultsIn this research, we identified 29 chemical compounds of the studied rosemary essential oil, and the main constituents were 1,8-cineole (43.77%), camphor (12.53%), and α-pinene (11.51%). Investigated essential oil was found to exert hepatoprotective effects in the doses of 5 mg/kg and 10 mg/kg by diminishing AST and ALT activities up to 2-fold in serum of rats with carbon tetrachloride - induced acute liver damage. Rosemary essential oil prevented carbon tetrachloride - induced increase of lipid peroxidation in liver homogenates. Furthermore, pre-treatment with studied essential oil during 7 days significantly reversed the activities of antioxidant enzymes catalase, peroxidase, glutathione peroxidase and glutathione reductase in liver homogenates, especially in the dose of 10 mg/kg.ConclusionsOur results demonstrate that rosemary essential oil, beside exhibiting free radical scavenging activity determined by DPPH assay, mediates its hepatoprotective effects also through activation of physiological defense mechanisms.

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Section: Discussionmentioning

confidence: 99%

Antioxidant activity of rosemary (Rosmarinus officinalis L.) essential oil and its hepatoprotective potential

Rašković

Milanović

Pavlović

et al. 2014

BMC Complement Altern Med

351

188

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“…They are complex aromatic oily liquids and most commonly contain terpenoids and phenylpropanoids. They are usually obtained from plants by steam distillation …”

Section: Essential Oils and Plant Extractsmentioning

confidence: 99%

Tackling scabies: novel agents for a neglected disease

2018

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The scabies mite, Sarcoptes scabiei var hominis, is an obligate ectoparasite of humans. It has been a source of distress for humanity since antiquity. The troublesome mite is emerging triumphant over current acaricidal agents with reports of emerging resistance and treatment failures. Scabies in endemic areas and crusted scabies offer additional management challenges. Exploration of indigenous plants and better understanding of mite biology and pathogenesis provide opportunities for the development of novel agents for this common pest. We review the recent diverse approaches to scabies, including the use of novel plant products with a better safety profile, translating the use of moxidectin from veterinary practice to human scabies, vaccination, immunotherapy, and development of drugs that directly target mite molecules.

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“…Adulteration of a pure substance occurs when it is intentionally altered by the addition of foreign materials or exposed to an environment that would induce a change [ 1 ]. In the context of the essential oil industry, adulteration can be used as a means to increase product yields, decrease production costs and/or enhance the perceived quality of the final product, with increased profit being the principal incentive [ 2 , 3 ]. Underlying this is the low manufacturing yields in comparison to the costs of high quality oil production and the sourcing of raw materials.…”

Section: Introductionmentioning

confidence: 99%

“…Modern methods routinely used for determining the composition and quality of essential oils include GC, high performance liquid chromatography (HPLC), Mass Spectrometry (MS) and Nuclear Magnetic Resonance (NMR) spectroscopy [ 2 ]. Chromatographic techniques such as GC and HPLC are used to separate essential oils into their individual constituents so that they can be identified and potentially quantified by a coupled detector such as a MS.…”

Section: Introductionmentioning

confidence: 99%

Chemometric Analysis of Lavender Essential Oils Using Targeted and Untargeted GC-MS Acquired Data for the Rapid Identification and Characterization of Oil Quality

et al. 2017

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Standard raw material test methods such as the ISO Standard 11024 are focused on the identification of lavender oil and not the actual class/quality of the oil. However, the quality of the oil has a significant effect on its price at market. As such, there is a need for raw material tests to identify not only the type of oil but its quality. This paper describes two approaches to rapidly identifying and classifying lavender oil. First, the ISO Standard 11024 test method was evaluated in order to determine its suitability to assess lavender oil quality but due to its targeted and simplistic approach, it has the potential to miss classify oil quality. Second, utilizing the data generated by the ISO Standard 11024 test methodology, an untargeted chemometric predicative model was developed in order to rapidly assess and characterize lavender oils (Lavandula angustifolia L.) for geographical/environmental adulteration that impact quality. Of the 170 compounds identified as per the ISO Standard 11024 test method utilizing GC-MS analyses, 15 unique compounds that greatly differentiate between the two classes of lavender were identified. Using these 15 compounds, a predicative multivariate chemometric model was developed that enabled lavender oil samples to be reliably differentiated based on quality. A misclassification analysis was performed and it was found that the predictions were sound (100% matching rate). Such an approach will enable producers, distributers, suppliers and manufactures to rapidly screen lavender essential oil. The authors concede that the validation and implementation of such an approach is more difficult than a conventional chromatographic assay. However, the rapid, reliable and less problematic screening is vastly superior and easily justifies any early implementation validation difficulties and costs.

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Essential oil composition

Cited by 51 publications

References 61 publications

Antioxidant activity of rosemary (Rosmarinus officinalis L.) essential oil and its hepatoprotective potential

Antioxidant activity of rosemary (Rosmarinus officinalis L.) essential oil and its hepatoprotective potential

Tackling scabies: novel agents for a neglected disease

Chemometric Analysis of Lavender Essential Oils Using Targeted and Untargeted GC-MS Acquired Data for the Rapid Identification and Characterization of Oil Quality

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