Essential oil composition of two Scutellaria species from Iran

Gharari, Zahra; Bagheri, Khadijeh; Danafar, Hossein; Sharafi, Ali

doi:10.1016/j.jtcms.2019.07.003

Cited by 14 publications

(15 citation statements)

References 31 publications

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“…Our finding for antioxidant potential was similar to some Scutellaria species: S. immaculata, S. ramosissima, and S. schachristanica [37]. Moreover, our listed data were also in favor of Zahra et al [36] which reported the essential oils of S. multicaulis and S. bornmuelleri for their antioxidant activity. due to the same assay and fungal strains used reported for the species belonging to the same genus Scutellaria.…”

Section: Antioxidant Assaysupporting

confidence: 88%

“…Our findings acceded with the data revealed by Yu et al [43] and Zhu et al [45] in the literature available for S. barbata and S. strigillosa, respectively. Our result consented to the data documented by Zahra et al [36] which screened S. multicaulis and S. bornmuelleri for the mentioned studies. The similarity was due to the same assay and fungal strains used that were reported for species belonging to the same genus Scutellaria and F. oxysporium in using the dose-dependent method in comparison with the standard and negative control (Figure 3B).…”

Section: Antifungal Assaysupporting

confidence: 81%

“…Our findings acceded with the literature data revealed by Yu et al [43] and Zhu et al [45] available for S. barbata and S. strigillosa, respectively. Our result consented to the data documented by Zahra et al [36] which screened S. multicaulis and S. bornmuelleri for the mentioned studies. The similarity was due to the same assay and fungal strains used reported for the species belonging to the same genus Scutellaria.…”

Section: Antifungal Assaysupporting

confidence: 81%

“…Therefore, we suggest that the oil, having a higher concentration of ethyl linoleate, ethyl oleate, linolenic acid, methyl ester, palmitic acid, and ethyl ester, may be useful as a safe whitening agent in cosmetics and a potential therapeutic agent for reducing skin hyperpigmentation in clinics. Moreover, other bioactive compounds as thymol, dodecanoic acid, ethyl ester, and phytol acetate are also present, which are well known for their medicinal values [36]. The aforementioned chemical constituents are already reported from S. brevibracteata [37], and S. heterophylla [38], belonging to the genus Scutellaria.…”

Section: Gc-ms Analysismentioning

confidence: 98%

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GC-MS Analysis and Biomedical Therapy of Oil from n-Hexane Fraction of Scutellaria edelbergii Rech. f.: In Vitro, In Vivo, and In Silico Approach

et al. 2021

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The current study aimed to explore the crude oils obtained from the n-hexane fraction of Scutellaria edelbergii and further analyzed, for the first time, for their chemical composition, in vitro antibacterial, antifungal, antioxidant, antidiabetic, and in vivo anti-inflammatory, and analgesic activities. For the phytochemical composition, the oils proceeded to gas chromatography-mass spectrometry (GC-MS) analysis and from the resultant chromatogram, 42 bioactive constituents were identified. Among them, the major components were linoleic acid ethyl ester (19.67%) followed by ethyl oleate (18.45%), linolenic acid methyl ester (11.67%), and palmitic acid ethyl ester (11.01%). Tetrazolium 96-well plate MTT assay and agar-well diffusion methods were used to evaluate the isolated oil for its minimum inhibitory concentrations (MIC), minimum bactericidal concentration (MBC), half-maximal inhibitory concentrations (IC50), and zone of inhibitions that could determine the potential antimicrobial efficacy’s. Substantial antibacterial activities were observed against the clinical isolates comprising of three Gram-negative bacteria, viz., Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa, and one Gram-positive bacterial strain, Enterococcus faecalis. The oils were also effective against Candida albicans and Fusarium oxysporum when evaluated for their antifungal potential. Moreover, significant antioxidant potential with IC50 values of 136.4 and 161.5 µg/mL for extracted oil was evaluated through DPPH (1,1-Diphenyl-2-picryl-hydrazyl) and ABTS assays compared with standard ascorbic acid where the IC50 values were 44.49 and 67.78 µg/mL, respectively, against the tested free radicals. The oils was also potent, inhibiting the α-glucosidase (IC50 5.45 ± 0.42 µg/mL) enzyme compared to the standard. Anti-glucosidase potential was visualized through molecular docking simulations where ten compounds of the oil were found to be the leading inhibitors of the selected enzyme based on interactions, binding energy, and binding affinity. The oil was found to be an effective anti-inflammatory (61%) agent compared with diclofenac sodium (70.92%) via the carrageenan-induced assay. An appreciable (48.28%) analgesic activity in correlation with the standard aspirin was observed through the acetic acid-induced writhing bioassay. The oil from the n-hexane fraction of S. edelbergii contained valuable bioactive constituents that can act as in vitro biological and in vivo pharmacological agents. However, further studies are needed to uncover individual responsible compounds of the observed biological potentials which would be helpful in devising novel drugs.

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Section: Antioxidant Assaysupporting

confidence: 88%

Section: Antifungal Assaysupporting

confidence: 81%

Section: Antifungal Assaysupporting

confidence: 81%

Section: Gc-ms Analysismentioning

confidence: 98%

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GC-MS Analysis and Biomedical Therapy of Oil from n-Hexane Fraction of Scutellaria edelbergii Rech. f.: In Vitro, In Vivo, and In Silico Approach

et al. 2021

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“…The retention index of each compound was calculated by using n-alkanes standards (C 8 –C 40 ). The compounds were identified by comparing the mass spectra of each chromatographic peak in the NIST05 library and comparing their calculated retention indexes with the retention indexes in the literature [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ].…”

Section: Methodsmentioning

confidence: 99%

Essential Oils from Zingiber striolatum Diels Attenuate Inflammatory Response and Oxidative Stress through Regulation of MAPK and NF-κB Signaling Pathways

Huang

Xie

et al. 2021

Antioxidants

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Zingiber striolatum Diels (Z. striolatum), a widely popular vegetable in China, is famous for its medicinal and nutritional values. However, the anti-inflammatory effects of essential oil from Z. striolatum (EOZS) remain unclear. In this study, EOZS from seven regions in China were extracted and analyzed by GC–MS. LPS-induced RAW264.7 cells and 12-O-Tetradecanoylphorbol 13-acetate (TPA)-stimulated mice were used to evaluate the anti-inflammatory effects of EOZS. Results show that 116 compounds were identified in EOZS from seven locations. Samples 2, 4 and 5 showed the best capability on DPPH radical scavenging and NO inhibition. They also significantly reduced the production of ROS, pro-inflammatory cytokines, macrophage morphological changes, migration and phagocytic capability. Transcriptomics revealed MAPK and NF-κB signaling pathways may be involved in the anti-inflammatory mechanism, and the predictions were proven by Western blotting. In TPA-induced mice, EOZS reduced the degree of ear swelling and local immune cell infiltration by blocking the activation of MAPK and NF-κB signaling pathways, which was consistent with the in vitro experimental results. Our research unveils the antioxidant capability and potential molecular mechanism of EOZS in regulating inflammatory response, and suggests the application of EOZS as a natural antioxidant and anti-inflammatory agent in the pharmaceutical and functional food industries.

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Bioactive Analysis of Antibacterial Efficacy and Antioxidant Potential of Aloe barbadensis Miller Leaf Extracts and Exploration of Secondary Metabolites Using GC–MS Profiling

Palaniyappan

Sridhar

Arumugam

et al. 2023

Appl Biochem Biotechnol

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Essential oil composition of two Scutellaria species from Iran

Cited by 14 publications

References 31 publications

GC-MS Analysis and Biomedical Therapy of Oil from n-Hexane Fraction of Scutellaria edelbergii Rech. f.: In Vitro, In Vivo, and In Silico Approach

GC-MS Analysis and Biomedical Therapy of Oil from n-Hexane Fraction of Scutellaria edelbergii Rech. f.: In Vitro, In Vivo, and In Silico Approach

Essential Oils from Zingiber striolatum Diels Attenuate Inflammatory Response and Oxidative Stress through Regulation of MAPK and NF-κB Signaling Pathways

Bioactive Analysis of Antibacterial Efficacy and Antioxidant Potential of Aloe barbadensis Miller Leaf Extracts and Exploration of Secondary Metabolites Using GC–MS Profiling

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