Essential oil from Fructus Alpiniae zerumbet ameliorates vascular endothelial cell senescence in diabetes by regulating PPAR-γ signalling: A 4D label-free quantitative proteomics and network pharmacology study

Liao, Jiajia; Fu, Lingyun; Tai, Shidie; Xu, Yini; Wang, Shengquan; Guo, Linlin; Guo, Die; Du, Youqi; He, Jinggang; Yang, Hong; Hu, Xiaoxia; Tao, Ling; Shen, Xiangchun

doi:10.1016/j.jep.2023.117550

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…An in vivo study was also carried out in diabetic mice with Alpiniae zerumbet administered orally, ameliorating vascular endothelial cell senescence by activating PPAR-γ signalling [89].…”

Section: Cellular Senescencementioning

confidence: 99%

Plant Monoterpenes and Essential Oils as Potential Anti-Ageing Agents: Insights from Preclinical Data

Zuzarte,

Sousa,

Alves-Silva

et al. 2024

Biomedicines

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Ageing is a natural process characterized by a time-dependent decline of physiological integrity that compromises functionality and inevitably leads to death. This decline is also quite relevant in major human pathologies, being a primary risk factor in neurodegenerative diseases, metabolic disorders, cardiovascular diseases and musculoskeletal disorders. Bearing this in mind, it is not surprising that research aiming at improving human health during this process has burst in the last decades. Importantly, major hallmarks of the ageing process and phenotype have been identified, this knowledge being quite relevant for future studies towards the identification of putative pharmaceutical targets, enabling the development of preventive/therapeutic strategies to improve health and longevity. In this context, aromatic plants have emerged as a source of potential bioactive volatile molecules, mainly monoterpenes, with many studies referring to their anti-ageing potential. Nevertheless, an integrated review on the current knowledge is lacking, with several research approaches studying isolated ageing hallmarks or referring to an overall anti-ageing effect, without depicting possible mechanisms of action. Herein, we aim to provide an updated systematization of the bioactive potential of volatile monoterpenes on recently proposed ageing hallmarks, and highlight the main mechanisms of action already identified, as well as possible chemical entity–activity relations. By gathering and categorizing the available scattered information, we also aim to identify important research gaps that could help pave the way for future research in the field.

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“…An in vivo study was also carried out in diabetic mice with Alpiniae zerumbet administered orally, ameliorating vascular endothelial cell senescence by activating PPAR-γ signalling [89].…”

Section: Cellular Senescencementioning

confidence: 99%

Plant Monoterpenes and Essential Oils as Potential Anti-Ageing Agents: Insights from Preclinical Data

Zuzarte,

Sousa,

Alves-Silva

et al. 2024

Biomedicines

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“…Itokawa et al [105] isolated alpinetin (18) from the rhizomes in 1981. Ohtsuki et al [109] performed a phytochemical investigation of the rhizomes and isolated pinocembrin (16), naringenin (19), and 3-methoxykaempferol (21). Other researchers have isolated quercetin (22) [106] and kaempferol-3-O-glucuronide (23) [114] from the rhizomes.…”

Section: Flavonoidsmentioning

confidence: 99%

“…The rhizomes are also used as a preservative or flavoring condiment in alcoholic beverages [ 19 ], and the seeds are a popular aromatic stomachic [ 18 , 20 ]. The Miao people in Guizhou Province (China) have used the mature fruits (pericarps, placenta, and seeds) as cardiovascular disease treatments [ 7 , 21 , 22 ]. In India, the rhizomes have been applied to sufferers of catarrhal and rheumatism affections [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemicals of Alpinia zerumbet: A Review

Nishidono,

Tanaka

2024

Molecules

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Alpinia zerumbet (Pers.) B.L.Burtt & R.M.Sm is a perennial plant of the Zingiberaceae family widely distributed in the subtropical and tropical areas of South America, Oceania, and Asia. Multiple plant parts of A. zerumbet have been traditionally used as medicinal sources, each with different clinical uses. These variations may arise from differences among the chemical components and/or accumulations of the active compounds in each part. Therefore, this review summarizes previous studies on the phytochemicals in A. zerumbet and reveals the similarities and differences among the chemical constituents of its multiple medicinal parts, including the leaves, rhizomes, fruits, seeds, and flowers. The results contribute to the scientific validation of the traditional understanding that A. zerumbet possesses different medicinal properties in each plant part. In addition, this review provides directions for further studies on the phytochemicals of this plant.

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Inhibition of the miR-1914-5p increases the oxidative metabolism in cellular model of steatosis by modulating the Sirt1-PGC-1α pathway and systemic cellular activity

Porto-Barbosa,

Ramos,

Pansa

et al. 2024

PLoS ONE

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Metabolic associated fatty liver disease (MAFLD) is considered an indicator of metabolic syndrome, which affects millions of people around the world and no effective treatment is currently available. MAFLD involves a wide spectrum of liver damage, that initiates from steatosis (fatty live) and may progress to more complex pathophysiology. Then, details in lipid metabolism controlling should be explored aiming to control the fatty liver. In this context, the miR-1914-5p can be considered a potential biotechnology tool to control lipid metabolism in hepatic cells. This miRNA finds potential mRNA binding sequences in more than 100 molecules correlated with energy production and lipid metabolism pointed in bioinformatic platforms. The present study addressed the miR-1914-5p effects in hepatic HepG2/LX-2 co-cultured cells in a in vitro steatotic environment stablished by the addition of 400 μM of a mixture of oleic and palmitic acids. The analyses demonstrated that the inhibition of the miRNA reduced energetic metabolites such as total lipids, triglycerides, cholesterol and even glucose. In addition, the miR-inhibitor-transfected cells did not present any deleterious effect in cellular environment by controlling reactive oxygen species production (ROS), mitochondrial membrane potential (ΔΨm) and even the pro-inflammatory environment. Moreover, the functional effect of the investigated miR, suggested its close connection to the modulation of Sirt-1-PGC1-α pathway, a master switch metabolic route that controlls cellular energetic metabolism. Our assays also suggested a synergistic effect of this miR-1914-5p in cell metabolism, which should be considered as a strong candidate to control steatotic environment in future clinical trials.

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Essential oil from Fructus Alpiniae zerumbet ameliorates vascular endothelial cell senescence in diabetes by regulating PPAR-γ signalling: A 4D label-free quantitative proteomics and network pharmacology study

Cited by 4 publications

References 38 publications

Plant Monoterpenes and Essential Oils as Potential Anti-Ageing Agents: Insights from Preclinical Data

Plant Monoterpenes and Essential Oils as Potential Anti-Ageing Agents: Insights from Preclinical Data

Phytochemicals of Alpinia zerumbet: A Review

Inhibition of the miR-1914-5p increases the oxidative metabolism in cellular model of steatosis by modulating the Sirt1-PGC-1α pathway and systemic cellular activity

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