Essential Oil from Lemon Peels Inhibit Key Enzymes Linked to Neurodegenerative Conditions and Pro-oxidant Induced Lipid Peroxidation

Oboh, Ganiyu; Olasehinde, Tosin A.; Ademosun, Ayokunle O.

doi:10.5650/jos.ess13166

Cited by 57 publications

(51 citation statements)

References 43 publications

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“…Murali et al (2013) demonstrated the inhibitory effect of limonene on lipid peroxidation in experimental diabetic animals; hence, the inhibition of some pro-oxidants (Fe 2+ and SNP) induced lipid peroxidation in tissue homogenates of rat's pancreas, and heat by the essential oil could be due to the presence of limonene acting singly or synergistically with other antioxidant phytoconstituents of the essential oil. This finding is consistent with earlier reports on inhibition of MDA production or peroxide formation in mammalian tissues by plant components or extracts (Kelen and Tepe 2008;Oboh et al, 2014).…”

Section: Inhibition Of Lipid Peroxidationsupporting

confidence: 94%

Biological activities, antioxidant properties and phytoconstituents of essential oil from sweet basil (Ocimum basilicum L.) leaves

2015

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This study investigated the biological activities of essential oil from sweet basil leaves via its effect on α-amylase, α-glucosidase and angiotensin-I-converting enzyme (ACE) activities, inhibition of Fe 2+ and sodium nitroprusside (SNP)-induced lipid peroxidation in rats' pancreas and heart homogenates. The phytoconstituents of the oil were analysed using gas chromatography (GC). The essential oil exhibited a dose-dependent inhibition of α-amylase (IC 50 =3.21 mg/mL), α-glucosidase (IC 50 =3.06 mg/mL) and ACE (IC 50 =0.89 mg/ mL) activities in vitro. The oil also inhibited both Fe 2+ -and SNP-induced lipid peroxidation in rats' pancreas and heart. The GC analysis revealed the presence of about 28 phytoconstituents, with limonene (47.40 %), borneol (8.66 %), geranial (6.93 %), neral (5.71 %), myrcene (4.68 %), β-caryophyllene (4.68 %), α-terpineol (4.60 %), 1,8-cineole (4.17 %), linalool (3.53 %), β-elemene (3.05 %), germacrene D (2.68 %), and terpinen-4-ol (2.21 %) being the most prominent. Thus, the antioxidant and enzyme inhibitory effects of the essential oil could be attributed to the presence of these phytochemicals, which could be the principle responsible for the antidiabetic and antihypertensive properties of the essential oil. This study therefore, could provide the possible rationale for the application of essential oil from sweet basil leaves as functional foods and nutraceutical ingredient in the management of type 2 diabetes and hypertension.

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Section: Inhibition Of Lipid Peroxidationsupporting

confidence: 94%

Biological activities, antioxidant properties and phytoconstituents of essential oil from sweet basil (Ocimum basilicum L.) leaves

2015

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“…Inhibition of Fe 2+ ‐induced lipid peroxidation by the essential oils under study agreed with the reports of Kelen and Tepe () and Oboh et al . () on effective inhibition of reactive species by the plant essential oils and could be attributed to their bioactive chemicals such as limonene and linalool (Murali et al . ; Oboh et al .…”

Section: Resultsmentioning

confidence: 99%

“…; Oboh et al . ), or in synergy with other chemical compounds (Table ). Although the reason for the higher inhibition of MDA production by the seed essential oils could not be ascertained in this study, we suggested that the presence of volatile unsaturated fatty acids present in the seed essential oils (Table ) might have contributed immensely to the higher MDA inhibitory potential.…”

Section: Resultsmentioning

confidence: 99%

Comparative Study of Chemical Composition, In Vitro Inhibition of Cholinergic and Monoaminergic Enzymes, and Antioxidant Potentials of Essential Oil from Peels and Seeds of Sweet Orange (Citrus Sinensis [L.] Osbeck) Fruits

Ademosun

Oboh

Olupona

et al. 2015

Journal of Food Biochemistry

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This study was designed to compare the chemical compositions and effect of essential oils from the peels and seeds of sweet orange on cholinergic (acetylcholinesterase [AChE], butyrylcholinesterase [BChE]) and monoaminergic (monoamine oxidase [MAO]) enzymes. The ability of the essential oils to protect the brain against Fe2+‐induced lipid peroxidation was also investigated. Forty and forty‐four compounds were identified in peels and seed essential oils, respectively, using gas chromatography. The essential oils inhibited AChE, BChE and MAO in dose‐dependent manner. However, essential oil from the peels had higher inhibition on cholinergic enzymes but lower inhibitory effect on MAO and Fe2+‐induced lipid peroxidation compared to the seed essential oils. This study also revealed the presence of volatile compounds. Conclusively, both essential oils could be used as therapeutic agents in the management of Alzheimer's disease. Practical Applications Sweet orange (Citrus sinensis) peels and seeds are waste materials in the production of orange juice and can be used as a source to produce essential oils which can be of use in the production of functional foods and nutraceuticals. This study provided reference information for the first time on the chemical composition and potential application of sweet orange peels and seed essential oils in the treatment and management of Alzheimer's diseases.

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“…S. macrocarpon is known to have medicinal benefits and these benefits have been ascribed to the phytochemicals in it such as phenols and flavonoids (Adewale et al, 2014;Oboh, Olasehinde, & Ademosun, 2014). Phenolics or polyphenols present in plant and plant products are secondary metabolites (Adewale et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…The activities of cholinesterases are important in neurotransmission regulation by the hydrolysis of acetylcholine into choline and acetate (Martorana, Esposito, & Koch, 2010). In the brain of an Alzheimer's disease patient, the level of cholinesterase activity is increased, this leads the drastic decrease in acetylcholine in the brain leading to a loss of memory, inadequacy in cholinergic neurotransmission and cognitive abilities Oboh et al, 2014). Some studies have shown that in Alzheimer's disease there is an increase BChE activity.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effect of ethyl acetate fraction ofSolanum macrocarponL. leaves on cholinergic, monoaminergic, and purinergic enzyme activities

et al. 2018

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This study evaluated the inhibitory effect of ethyl acetate fraction of Solanum macrocarpon L. leaves on cholinergic, monoaminergic, purinergic enzyme activities and identification of bioactive compounds. 2,2‐azino‐bis‐3‐ethylbenthiazoline‐6‐sulphonic acid (ABTS), metal ion chelating radicals scavenging activity, total phenolic and flavonoid contents were determined using standard methods. The inhibitory effects of the ethyl acetate fraction of S. macrocarpon on the specified enzymes were determined spectroscopically. Ethyl acetate fraction of S. macrocarpon showed a high ABTS radical scavenging activity and metal ion chelating radical scavenging activity. The fraction showed high contents of phenol and flavonoid. The fraction also inhibited AChE, BChE, MOA, tyrosinase, arginase, ecto‐5′ ‐nucleotidase, PDE‐5, ACE and stimulated the activity of Na+/K+‐ATPase. Bioactive compounds present in ethyl acetate fraction of S. macrocarpon leaves include kaempferol‐3‐rutinoside, rutin among others. Ethyl acetate fraction of S. macrocarpon leaves inhibited cholinergic, monoaminergic, and purinergic enzymes and had a stimulatory effect on Na+/K+‐ATPase. Practical applications Solanum macrocarpon L. leaves are commonly consumed as vegetable. The enormous medicinal potential of the ethyl acetate fraction is invaluable as it’s a probable source of polyphenols characterized with strong antioxidant activity. In addition, the leaves are used as functional foods and may play a crucial role in the management/treatment of diabetes mellitus, neurodegenerative diseases, and erectile dysfunction.

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Essential Oil from Lemon Peels Inhibit Key Enzymes Linked to Neurodegenerative Conditions and Pro-oxidant Induced Lipid Peroxidation

Cited by 57 publications

References 43 publications

Biological activities, antioxidant properties and phytoconstituents of essential oil from sweet basil (Ocimum basilicum L.) leaves

Biological activities, antioxidant properties and phytoconstituents of essential oil from sweet basil (Ocimum basilicum L.) leaves

Comparative Study of Chemical Composition, In Vitro Inhibition of Cholinergic and Monoaminergic Enzymes, and Antioxidant Potentials of Essential Oil from Peels and Seeds of Sweet Orange (Citrus Sinensis [L.] Osbeck) Fruits

Inhibitory effect of ethyl acetate fraction ofSolanum macrocarponL. leaves on cholinergic, monoaminergic, and purinergic enzyme activities

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