Essential oil, juice, and ethanol extract from bergamot confer improving effects against primary dysmenorrhea in rats

Zhang, Nanhai; Kong, Fang; Zhao, Liang; Yang, Xue; Wu, Wei; Zhang, Liebing; Ji, Baoping; Zhou, Feng

doi:10.1111/jfbc.13614

Cited by 8 publications

(4 citation statements)

References 46 publications

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“…To the best of our knowledge, the present study rstly used label-free quantitative proteomics in a rat model of PD to identify the key proteins directly, rather than mRNAs. The in vivo rat model managed with estradiol benzoate and oxytocin is frequently used in PD studies [13][14][15]. The rat model of PD in the present study was successfully established by using this method.…”

Section: Discussionmentioning

confidence: 92%

Protein expression profiling of rat uteruses with primary dysmenorrhea syndrome

Xie

Qian

2021

Arch Gynecol Obstet

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Purpose The aim of this study was to investigate differentially expressed proteins (DEPs) and their functions in the uteruses of primary dysmenorrhea (PD) rats by using label-free quantitative proteomics analysis.Methods The PD rat model was induced by injecting both estradiol benzoate and oxytocin. Twenty rats were equally divided into two groups: a control group (normal rats), a PD model group (PD rats). Writhing scores and serum levels of Prostaglandin E2 (PGE2) and Prostaglandin F2α (PGF2α) were used to evaluate the success of the rat PD model. The DEPs were identi ed and analyzed by label-free quantitative proteomics and bioinformatics analyses.Results A total of 276 DEPs were identi ed, including 119 up-regulated DEPs and 157 down-regulated DEPs. Bioinformatics revealed that the DEPs were mainly associated with 'protein binding', 'metabolism', 'signal conduction' and 'focal adhesion'. The proteomic ndings were veri ed by western blot analysis, which con rmed that myosin light chain kinase (MLCK), heat shock protein 90 AB1 (HSP90AB1), apolipoprotein A1 (Apoa1), p38 MAP kinase, c-Jun N-terminal kinase (JNK), and extracellular signalrelated kinase 1/2 (ERK1/2) were signi cantly differentially expressed in between the control and PD samples.Conclusions These results provide a deeper understanding the molecular pathogenesis of PD. The DEPs found in the present study may provide new ideas for further study of the mechanism of PD and aid the search for biomarkers for early diagnosis and treatment.

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Section: Discussionmentioning

confidence: 92%

Protein expression profiling of rat uteruses with primary dysmenorrhea syndrome

Xie

Qian

2021

Arch Gynecol Obstet

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“…Therefore, all studies evaluating the antiinflammatory and antioxidant effects on humans and not on animal models or cell lines or in vitro were included. The articles excluded, because they did not meet the inclusion criteria, were divided into 3 groups: excluded because they were not full-text [30][31][32][33][34][35], ex-cluded because they were performed on animal models [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51]., excluded because they were performed on cellular lines or in vitro [52][53][54][55][56]. In more detail, in their study, Giovanni Enrico Lombardo and colleagues analyzed the anti-inflammatory and antinociceptive activity of bergamot oil.…”

Section: Methodsmentioning

confidence: 99%

Anti-Inflammatory Effects of Bergamot on the Elderly: A Literature Review

Calabrò,

Bagnato,

Cerchiaro

et al. 2023

Act Scie Nutr

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Background: Bergamot (Citrus bergamia) is a plant belonging to the Rutaceae family, genus "Citrus". The cultivation of this plant is concentrated almost exclusively in a narrow geographical area of Calabria (Italy), in particular, in the Reggio Calabria area. Bergamot has been heavily used in the cosmetic industry but, in recent years, it is also embracing the medical branch due to its properties and effects, not only cholesterol-lowering but also anti-inflammatory and antioxidant. Like most citrus fruits, Bergamot is also rich in flavonoids (phenolic derivatives with antioxidant capacity) present in the form of more polar glycosidic derivatives, such as neoeriocitrin, naringin and neoesperidin. It is now known how, bergamot extracts could represent the scientific basis for the development of new and alternative strategies, in order to improve the state of health and mitigate inflammatory conditions. Objectives:The goal of our study was to analyze, through the scientific literature, the effects and anti-inflammatory and / or antioxidant properties of Bergamot on humans, particularly in the elderly. Methods:We have drawn up a flow chart and compared the studies in the literature through the use of Pubmed, on the anti-inflammatory effects of Bergamot on humans. In the present study, only 2 scientific studies partially met our objectives.Results: Despite the many scientific articles on Bergamot, to date there are still few those relating to the anti-inflammatory and/or antioxidant effects of Bergamot on humans. We excluded studies performed on mouse models, or in vitro, while others were excluded as they were not full-text.Conclusions: An adequate and balanced diet, especially in the elderly, is an important factor of longevity and health. Inflammatory diseases represent an important risk factor for various chronic diseases, including those typical of old age. Often in the geriatric age there are greater comorbidities that are associated with a progressive loss of lean mass and an increase in fat mass, due to the presence of an inflammatory state. Furthermore, aging could also cause a dysregulation of the immune system and an increase in the production of reactive oxygen species (ROS). All this translates into greater susceptibility to disease and reduced healing capacity in the elderly, in fact, we are talking about the frailty of the elderly. Several classes of drugs, including corticosteroids, non-steroidal antiinflammatory drugs (NSAIDs), and biologics are used to treat inflammatory disorders. However, they have several side effects, and biological ones are often expensive. To limit the side effects of these, in recent years, attention has shifted to the use of nutraceuticals in the treatment of inflammation. Of the many nutraceuticals we have focused our attention on Bergamot, as the polyphenols contained exert an anti-inflammatory activity both through antioxidant effects and by modulating the fundamental pro-inflammatory genes.

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“…In addition, BEO, and to a minor extent BJ and an ethanol bergamot extract, was shown to be effective in gynecological disorders such as primary dysmenorrhea induced by estradiol benzoate and oxytocin in rats. These bergamot derivatives alleviated dysmenorrhea, regulating the levels of PGF 2α and PGE 2 prostaglandins and the release of inflammatory mediators such as iNOS as well as activating the antioxidant defense mechanisms in the uterine tissue of rats [ 96 ]. Clinically, innovative results came from the treatment of patients affected by anitis/proctitis after treatment with a bergamot oil (known as Benebeo ® gel, Wellvit, Cosenza, Italia).…”

Section: Anti-inflammatory Activity Of Bergamot Derivatives and Bypro...mentioning

confidence: 99%

Bergamot Byproducts: A Sustainable Source to Counteract Inflammation

Russo,

Lombardo,

Bruschetta

et al. 2024

Nutrients

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Chronic inflammation is the result of an acute inflammatory response that fails to eliminate the pathogenic agent or heal the tissue injury. The consequence of this failure lays the foundations to the onset of several chronic ailments, including skin disorders, respiratory and neurodegenerative diseases, metabolic syndrome, and, eventually, cancer. In this context, the long-term use of synthetic anti-inflammatory drugs to treat chronic illnesses cannot be tolerated by patients owing to the severe side effects. Based on this, the need for novel agents endowed with anti-inflammatory effects prompted to search potential candidates also within the plant kingdom, being recognized as a source of molecules currently employed in several therapeutical areas. Indeed, the ever-growing evidence on the anti-inflammatory properties of dietary polyphenols traced the route towards the study of flavonoid-rich sources, such as Citrus bergamia (bergamot) and its derivatives. Interestingly, the recent paradigm of the circular economy has promoted the valorization of Citrus fruit waste and, in regard to bergamot, it brought to light new evidence corroborating the anti-inflammatory potential of bergamot byproducts, thus increasing the scientific knowledge in this field. Therefore, this review aims to gather the latest literature supporting the beneficial role of both bergamot derivatives and waste products in different models of inflammatory-based diseases, thus highlighting the great potentiality of a waste re-evaluation perspective.

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Essential oil, juice, and ethanol extract from bergamot confer improving effects against primary dysmenorrhea in rats

Cited by 8 publications

References 46 publications

Protein expression profiling of rat uteruses with primary dysmenorrhea syndrome

Protein expression profiling of rat uteruses with primary dysmenorrhea syndrome

Anti-Inflammatory Effects of Bergamot on the Elderly: A Literature Review

Bergamot Byproducts: A Sustainable Source to Counteract Inflammation

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