2017
DOI: 10.9740/mhc.2017.07.147
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Essential oil of lavender in anxiety disorders: Ready for prime time?

Abstract: Anxiety disorders are some of the most common psychiatric disorders, with potentially debilitating consequences on individual function. Existing pharmacotherapies for anxiety disorders are limited by delay to therapeutic effect, dependence, tolerance, withdrawal, and abuse potential. Therefore, safe and evidence-based complementary or alternative therapies may be important allies in the care of patients with anxiety disorders. Essential oils are lipophilic and concentrated botanical extracts that exhibit many … Show more

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Cited by 92 publications
(74 citation statements)
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“…LEO as a safe (GRAS) natural product of plants could be a good candidate to investigate its application in skin antiseptic formulation. According to literature data, LEO is well-tolerated on the surface of skin and is often administered orally or applied topically in an undiluted form [20]. However, Prashar et al [28] showed cytotoxic activity of LEO containing mainly linalyl acetate (51%) and linalool (35%) on human skin cells (HMEC-1, HNDF, and 153BR) at a concentration of 0.25% (v/v).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…LEO as a safe (GRAS) natural product of plants could be a good candidate to investigate its application in skin antiseptic formulation. According to literature data, LEO is well-tolerated on the surface of skin and is often administered orally or applied topically in an undiluted form [20]. However, Prashar et al [28] showed cytotoxic activity of LEO containing mainly linalyl acetate (51%) and linalool (35%) on human skin cells (HMEC-1, HNDF, and 153BR) at a concentration of 0.25% (v/v).…”
Section: Discussionmentioning
confidence: 99%
“…In addition, this oil has various pharmacological effects described in the available literature, such as antibacterial, antifungal, antioxidant, anxiolytic, anticonvulsant, and anticholinesterase properties [14][15][16][17][18][19]. According to Malcolm and Tallian [20], LEO is classified as Generally Recognized as Safe (GRAS) by the Food and Drugs Administration (FDA) (21CFR182.20 2015).…”
Section: Introductionmentioning
confidence: 99%
“…Most likely, this essential oil influenced other intracellular pathways to determine a concentration-dependent inhibition of neuronal networks and provoke the sedative effect on the CNS described in other studies [ 15 , 16 ]. Recent reports show that LA essential oil lacked appreciable affinity for norepinephrine or dopamine reuptake transporters, as well as monoamine oxidase-A or gamma-aminobutyric acid-A receptors, although LA essential oil and its main components exert affinity for the glutamate NMDA-receptor in a dose-dependent manner and also bind to the serotonin transporter [ 14 , 31 ]. These actions have been confirmed using positron emission tomography and magnetic resonance imaging scanning after 8 weeks of administering LA essential oil, since a reduced binding potential at the 5HT1A receptor in the hippocampus and the anterior cingulate cortex has been observed [ 54 , 55 ].…”
Section: Discussionmentioning
confidence: 99%
“…Numerous studies have reported long-lasting anxiety, anhedonia, and depressive-like symptomatology in defeated animals, which also show increased vulnerability to mental illnesses and higher drug intake [ 26 , 27 , 28 , 29 , 30 ]. Although, treatment with essential oils in humans reduces anxiety and depressive symptoms [ 31 ], the effect of these essences has not been directly studied in socially stressed animals. However, preliminary studies in humans under social stress indicate a potential positive effect [ 32 ].…”
Section: Introductionmentioning
confidence: 99%
“…There is no reported evidence of typical toxicological information such as acceptable daily intake or observed the adverse effect of botanicals usage (Kumar et al, 2017). Conversely, the botanicals and essential oils are usually classified as substances generally recognized as safe (Malcolm and Tallian, 2018).…”
Section: Characteristics Of Botanicals and Essential Oilsmentioning
confidence: 99%