Essential oil of lemon myrtle (Backhousia citriodora) induces S-phase cell cycle arrest and apoptosis in HepG2 cells

Wang, Yun-Fen; Zheng, Yufeng; Yin-Yue, Cha; Yang, Feng; Dai, Shao‐Xing; Zhao, Suping; Chen, Hao; Xu, Min

doi:10.1016/j.jep.2023.116493

Cited by 7 publications

(5 citation statements)

References 83 publications

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“…Cytotoxicity assay: The toxicity of Artemisia essential oils on HEK-293T cells (human embryonic kidney 293 cells, were obtained from the Kunming Cell Bank of Chinese Academic of Sciences) was detected using the MTT method, consistent with the previous study [71]. Cells were treated with Artemisia essential oils (25, 50, 100 µg/mL) for 24 h. The cells incubated with 3 µM paclitaxel (PTX) (Adamas Reagent Co., Ltd., 48803A, Shanghai, China) was used as the positive control (paclitaxel was drugs widely used clinically for the treatment of cancer).…”

Section: Toxicity Analysissupporting

confidence: 67%

Comparative Analysis of Active Ingredients and Potential Bioactivities of Essential Oils from Artemisia argyi and A. verlotorum

et al. 2023

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Artemisia argyi H. Lév. and Vaniot is a variety of Chinese mugwort widely cultured in central China. A. verlotorum Lamotte, another variety of Chinese mugwort, has been used in the southern region of China since ancient times. Despite their similar uses in traditional medicine, little is known about the differences in their active ingredients and potential benefits. Herein, the chemical compositions of the essential oils (EOs) from both varieties were analyzed using chromatography-mass spectrometry (GC-MS). A series of databases, such as the Traditional Chinese Medicine Systems Pharmacology database (TCMSP), SuperPred database and R tool, were applied to build a networking of the EOs. Our results revealed significant differences in the chemical compositions of the two Artemisia EOs. However, we found that they shared similar ingredient–target–pathway networking with diverse bioactivities, such as neuroprotective, anti-cancer and anti-inflammatory. Furthermore, our protein connection networking analysis showed that transcription factor p65 (RELA), phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) and mitogen-activated protein kinase 1 (MAPK1) are crucial for the biological activity of Artemisia EOs. Our findings provided evidence for the use of A. verlotorum as Chinese mugwort in southern China.

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Section: Toxicity Analysissupporting

confidence: 67%

Comparative Analysis of Active Ingredients and Potential Bioactivities of Essential Oils from Artemisia argyi and A. verlotorum

et al. 2023

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“…JUN plays an essential role in tumour growth and progression by modulating several signalling pathways, including the MAPK signalling pathway [ 36 ]. p53 is a tumour suppressor gene, and its loss of function mutation leads to carcinogenesis [ 37 ]. Most human malignancies frequently exhibit mutations in the p53 gene, with p53 mutations accounting for over 50% of patients with non-small cell lung cancer (NSCLC) [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

Elucidating the anti-cancer potential of Cinnamomum tamala essential oil against non-small cell lung cancer: A multifaceted approach involving GC-MS profiling, network pharmacology, and molecular dynamics simulations

Mohanty,

Padhee,

Priyadarshini

et al. 2024

Heliyon

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“…Wang et al. ( 136 ) found that the essential oil of Backhousia citriodora could induces HepG2 cells S-phase cell cycle arrest and apoptosis. From Vernonia extensa , three elemane-type sesquiterpenoids, vernodalin, vernolepin, and vernolide were purified and exhibited apoptosis-inductive effect in HepG2 cells ( 137 ).…”

Section: Discussionmentioning

confidence: 99%

Progress of natural sesquiterpenoids in the treatment of hepatocellular carcinoma

Wang,

Meng,

Mao

2024

Front. Oncol.

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Hepatocellular carcinoma is one of the common malignant tumors of digestive tract, which seriously threatens the life of patients due to its high incidence rate, strong invasion, metastasis, and prognosis. At present, the main methods for preventing and treating HCC include medication, surgery, and intervention, but patients frequently encounter with specific adverse reactions or side effects. Many Traditional Chinese medicine can improve liver function, reduce liver cancer recurrence and have unique advantages in the treatment of HCC because of their acting mode of multi-target, multi-pathway, multi-component, and multi-level. Sesquiterpenoids, a class of natural products which are widely present in nature and exhibit good anti-tumor activity, and many of them possess good potential for the treatment of HCC. This article reviewed the anti-tumor activities, natural resources, pharmacological mechanism of natural sesquiterpenoids against HCC, providing the theoretical basis for the prevention and treatment of HCC and a comprehensive understanding of their potential for development of new clinical drugs.

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Essential oil of lemon myrtle (Backhousia citriodora) induces S-phase cell cycle arrest and apoptosis in HepG2 cells

Cited by 7 publications

References 83 publications

Comparative Analysis of Active Ingredients and Potential Bioactivities of Essential Oils from Artemisia argyi and A. verlotorum

Comparative Analysis of Active Ingredients and Potential Bioactivities of Essential Oils from Artemisia argyi and A. verlotorum

Elucidating the anti-cancer potential of Cinnamomum tamala essential oil against non-small cell lung cancer: A multifaceted approach involving GC-MS profiling, network pharmacology, and molecular dynamics simulations

Progress of natural sesquiterpenoids in the treatment of hepatocellular carcinoma

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