Essential oil of Xylopia aethiopica from Cameroon: Chemical composition, antiradical and in vitro antifungal activity against some mycotoxigenic fungi

Tegang, Alphonse Sokamte; Beumo, Thierry Marcel Ntsamo; Dongmo, Pierre Michel Jazet; Ngoune, Léopold Tatsadjieu

doi:10.1016/j.jksus.2017.09.011

Cited by 24 publications

(20 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Xylopia aethiopica (XA) which is a member of the family Annonaceae, is used as a spice in Western and Central Africa, as well as to treat bronchitis, headache and ulceration [5]. In addition to its anti-diabetic effect [6], anti-anaphylactic and anti-inflammatory activities [7], several studies have shown that XA extracts possess antibacterial and antifungal activities [8][9][10][11]. Imperata cylindrica (IC) (family Poaceae) also known as spear grass in West Africa, has diuretic, anti-inflammatory and antibacterial activities [12,13].…”

Section: Introductionmentioning

confidence: 99%

Potent Cytotoxicity of Four Cameroonian Plant Extracts on Different Cancer Cell Lines

et al. 2020

View full text Add to dashboard Cite

In this study, the potential cytotoxicity of four plant extracts originated from Cameroon: Xylopia aethiopica (XA), Imperata cylindrica (IC), Echinops giganteus (EG) and Dorstenia psilurus (DP) were examined in vitro. We tested the anti-proliferative activity of the methanolic extracts of these compounds using MTT assay on seven different human cancer cell lines: HeLa, MDA-MB-231, A549, HepG2, U-87, SK-OV-3 and HL60. Induction of cell death was assessed by cell cycle analysis, apoptosis was determined by Annexin V-FITC binding and caspase 3/7 activity. As well, changes in mitochondrial membrane potential (MMP) and cell migration were tested. The genetic toxicity, using the alkaline comet assay, was evaluated. The studied extracts inhibited the cell proliferation of all tested cancer cell lines with concentration dependent effect over time. All of these extracts mainly induced apoptosis of HeLa cells by the accumulation of hypodiploid cells in the sub-G0/G1 phase and increasing the activity of caspase 3/7, as well they showed potential MMP disturbance and expressed a marked inhibitory effect on cell migration. Assessment of probable genetic toxicity by these extracts revealed no or minimum incidence of genetic toxicity. Therefore, the studied plant extracts are exhibiting potent anticancer activity based upon marked induction of tumor-cell death.

show abstract

Section: Introductionmentioning

confidence: 99%

Potent Cytotoxicity of Four Cameroonian Plant Extracts on Different Cancer Cell Lines

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The value is comparable to that previously reported by Olonisakin et al 18 from dry fruits of X. aethiopica obtained from Nigeria (which was 1.2% (v/w)). The value is, however, lower than that discussed elsewhere in Africa where Tegang et al 10 reported extraction yield of 4.2% (v/w) for dry fruits of X. aethiopica Cameroun and Bakan-Vla et al 6 also reported similar values of 3.57% (v/w) and 4.68% (v/w) from dry fruits of X. aethiopica, respectively. The dissimilarity in the extraction yield could be attributed to plant age, provenance, weather, soil conditions (in the cultivation of the spice), harvest time, and extraction technique, as well as the drying technique, employed in the processing of the essential oils 19,20 .…”

Section: Discussionmentioning

confidence: 52%

“…The dissimilarity in the extraction yield could be attributed to plant age, provenance, weather, soil conditions (in the cultivation of the spice), harvest time, and extraction technique, as well as the drying technique, employed in the processing of the essential oils 19,20 . Several previous studies on the chemical profile of the essential oils of X. aethiopica reported in Nigeria and within the West Africa sub-region show that the oils contain more than 70 different chemical compounds which can be divided into four chemical classes: monoterpene hydrocarbons, oxygenated monoterpenes, oxygenated sesquiterpenes, and sesquiterpene hydrocarbons 6,7,10,[21][22][23][24] . Zárybaický et al 25 communicated in a review that several of these monoterpenes and sesquiterpenes have demonstrated hepatotoxicity which were linked to reactive metabolite formation and increased oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…There are several documented reports on the usefulness of this spice in traditional medicine to relieve toothache, dysentery, diarrhea, dermatitis, headache, cough, stomach ache, dizziness, amenorrhea, bronchitis, neuralgia, flatulence (as a carminative), female sterility, bowel issues (as a purgative), biliousness, and skin infections. Previous studies on the essential oils of X. aethiopica fruit have extensively reported on their chemical compositions [4][5][6][7] , as well as the antimicrobial, antifungal, antineoplastic and antihypertensive potencies in cells and animal models 6,[8][9][10] . Despite the reported numerous biochemical effects of the essential oils of X. aethiopica fruit, no toxicological data is available regarding the safety evaluation of the essential oils from the plant spice.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Safety assessment of essential oils from Xylopia aethiopica (Dunal) fruit from Nigeria

2020

View full text Add to dashboard Cite

Introduction: The essential oils of Xylopia aethiopica fruits have been reported to possess numerous biochemical effects. However, no toxicological data is available regarding the safety evaluation of the essential oils from the plant spice. The present study was performed to evaluate the safety of essential oils from X. aethiopica (XAEO) fruit by acute and sub-acute oral toxicity studies in experimental rodents. Methods: In assessing the safety of XAEO, acute and sub-acute oral toxicity tests were performed following OECD guidelines 425 and 407, respectively, with slight modifications. At the end of each test, hematological and biochemical analysis of the collected blood was performed. Histopathological examination of vital organs of the animals was conducted for gross findings and for comparison to controls. Results: In acute oral toxicity, signs of toxicity were observed in the initial period of the experiment which culminated in the death of the mice before the end of the experiment. The sub-acute test observations indicated that generally, there were no significant differences (p<0.05) up to the high dose level compared to the controls. Conclusion: This study demonstrated the tolerability of XAEO administered daily for 28 days up to 450 mg/kg dose.

show abstract

“…The compounds β-pinene and α-pinene were also identified in the EO of Xylopia aethiopica , according to the analysis by Tegang et al [ 64 ] with contents of 32.16 ± 3.69% and 7.39 ± 1.69%, respectively. Kouame et al [ 65 ] found that the EOs of the leaves and fruits of a sample of X. aethopica were also characterized by β-pinene (16.01–20.50%) and α-pinene (10.39–17.77%).…”

Section: Resultsmentioning

confidence: 99%

Chemical Evaluation, Phytotoxic Potential, and In Silico Study of Essential Oils from Leaves of Guatteria schomburgkiana Mart. and Xylopia frutescens Aubl. (Annonaceae) from the Brazilian Amazon

et al. 2023

View full text Add to dashboard Cite

The essential oils (EOs) of Guatteria schomburgkiana (Gsch) and Xylopia frutescens (Xfru) (Annonaceae) were obtained by hydrodistillation, and their chemical composition was evaluated by gas chromatography-mass spectrometry (GC/MS). Herbicide activity was measured by analyzing the seed germination percentage and root and hypocotyl elongation of two invasive species: Mimosa pudica and Senna obtusifolia. The highest yield was obtained for the EO of Xfru (1.06%). The chemical composition of Gsch was characterized by the presence of the oxygenated sesquiterpenes spathulenol (22.40%) and caryophyllene oxide (14.70%). Regarding the EO of Xfru, the hydrocarbon monoterpenes α-pinene (35.73%) and β-pinene (18.90%) were the components identified with the highest concentrations. The germination of seeds of S. obtusifolia (13.33 ± 5.77%) showed higher resistance than that of seeds of M. pudica (86.67 ± 5.77%). S. obtusifolia was also more sensitive to the EO of Xfru in terms of radicle (55.22 ± 2.72%) and hypocotyl (71.12 ± 3.80%) elongation, while M. pudica showed greater sensitivity to the EO of Gsch. To screen the herbicidal activity, the molecular docking study of the major and potent compounds was performed against 4-hydroxyphenylpyruvate dioxygenase (HPPD) protein. Results showed good binding affinities and attributed the strongest inhibitory activity to δ-cadinene for the target protein. This work contributes to the study of the herbicidal properties of the EOs of species of Annonaceae from the Amazon region.

show abstract

Essential oil of Xylopia aethiopica from Cameroon: Chemical composition, antiradical and in vitro antifungal activity against some mycotoxigenic fungi

Cited by 24 publications

References 20 publications

Potent Cytotoxicity of Four Cameroonian Plant Extracts on Different Cancer Cell Lines

Potent Cytotoxicity of Four Cameroonian Plant Extracts on Different Cancer Cell Lines

Safety assessment of essential oils from Xylopia aethiopica (Dunal) fruit from Nigeria

Chemical Evaluation, Phytotoxic Potential, and In Silico Study of Essential Oils from Leaves of Guatteria schomburgkiana Mart. and Xylopia frutescens Aubl. (Annonaceae) from the Brazilian Amazon

Contact Info

Product

Resources

About