Essential Oils from Leaves of Medicinal Plants of Brazilian Flora: Chemical Composition and Activity against Candida Species

Costa, Maria da Conceição Mendes Ferreira da; Silva, Alexandre Gomes da; Silva, Ana Paula Sant'Anna da; Lima, Vera Lúcia de Menezes; Bezerra-Silva, Patrícia Cristina; Rocha, Suyana Karolyne Lino da; Navarro, Daniela Maria do Amaral Ferraz; Correia, Maria Tereza dos Santos; Napoleão, Thiago Henrique; Silva, Márcia Vanusa da; Paiva, Patrícia Maria Guedes

doi:10.3390/medicines4020027

Cited by 25 publications

(14 citation statements)

References 30 publications

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“…Plant extracts and essential oils derived from the leaves of plants of Brazilian origin described by Costa et al (2017) , such as Hymenaea courbaril var. courbaril , Myroxylon peruiferum , and Vismia guianensis , have shown therapeutic potential in this regard.…”

Section: Introductionmentioning

confidence: 99%

Pathogenesis and Clinical Relevance of Candida Biofilms in Vulvovaginal Candidiasis

et al. 2020

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The ability of Candida spp. to form biofilms is crucial for its pathogenicity, and thus, it should be considered an important virulence factor in vulvovaginal candidiasis (VVC) and recurrent VVC (RVVC). Its ability to generate biofilms is multifactorial and is generally believed to depend on the site of infection, species and strain involved, and the microenvironment in which the infection develops. Therefore, both cell surface proteins, such as Hwp1, Als1, and Als2, and the cell wall-related protein, Sun41, play a critical role in the adhesion and virulence of the biofilm. Immunological and pharmacological approaches have identified the NLRP3 inflammasome as a crucial molecular factor contributing to host immunopathology. In this context, we have earlier shown that Candida albicans associated with hyphae-secreted aspartyl proteinases (specifically SAP4-6) contribute to the immunopathology of the disease. Transcriptome profiling has revealed that non-coding transcripts regulate protein synthesis post-transcriptionally, which is important for the growth of Candida spp. Other studies have employed RNA sequencing to identify differences in the 1,245 Candida genes involved in surface and invasive cellular metabolism regulation. In vitro systems allow the simultaneous processing of a large number of samples, making them an ideal screening technique for estimating various physicochemical parameters, testing the activity of antimicrobial agents, and analyzing genes involved in biofilm formation and regulation ( in situ ) in specific strains. Murine VVC models are used to study C. albicans infection, especially in trials of novel treatments and to understand the cause(s) for resistance to conventional therapeutics. This review on the clinical relevance of Candida biofilms in VVC focuses on important advances in its genomics, transcriptomics, and proteomics. Moreover, recent experiments on the influence of biofilm formation on VVC or RVVC pathogenesis in laboratory animals have been discussed. A clear elucidation of one of the pathogenesis mechanisms employed by Candida biofilms in vulvovaginal candidiasis and its applications in clinical practice represents the most significant contribution of this manuscript.

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Section: Introductionmentioning

confidence: 99%

Pathogenesis and Clinical Relevance of Candida Biofilms in Vulvovaginal Candidiasis

et al. 2020

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“…activity of essential oils from leaves of Hymenaea courbaril var. courbaril, Myroxylon peruiferum, and Vismia guianensis from Brazil was assessed by Costa et al [99]. The oils containing caryophyllene oxide, trans-caryophyllene, spathulenol, α-pinene and humulene epoxide II showed antifungal activity against C. albicans, C. tropicalis, C. parapsilosis, C. glabrata, and C. krusei, demonstrating to have a good potential for clinical applications in the treatment of oral candidiasis.…”

Section: The Plant Extracts Composition Is Variable Depending On Thementioning

confidence: 99%

Promising Alternative Therapeutics for Oral Candidiasis

Rodrigues

Henriques

2019

CMC

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“…33448/rsd-v9i11.9787 In this context, essential oils, which have a complex mixture of volatile substances and act synergistically in the control of various insect pests, have been shown as an alternative strategy within Integrated Pest Management. This occurs not only because they do not leave residues in food or the environment, but also because they are generally rapidly degraded, which mitigates environmental contamination (Azevedo et al, 2013;Costa et al, 2017;Isman, 2006;Lima et al, 2013). Other characteristics include their action on mortality, deformations of the different stages of development, repellency and deterrence (Castro et al, 2006;G.…”

Section: Introductionmentioning

confidence: 99%

Chemical analysis and insecticidal activity of Ocimum gratissimum essential oil and its major constituent against Spodoptera frugiperda (Smith, 1797) (Lepidoptera: Noctuidae)

Monteiro

Oliveira

et al. 2020

RSD

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The fall armyworm, Spodoptera frugiperda, causes damage at several stages of the maize crop cycle. Due to its resistance to synthetic insecticides and the high costs of pest control, there is an ever-increasing amount of research on alternative or complementary products that have a minor environmental and financial impact on agriculture. Therefore, the aim of this study was to evaluate the chemical composition and insecticidal potential of Ocimum gratissimum (african basil) leaves essential oil and the effect of its major component, thymol, on S. frugiperda control. Gas Chromatography (GC) and Gas Chromatography-Mass Spectrometry (GC-MS) analysis identified p-cymene, γ-terpinene, and thymol compounds as the main constituents of the oil, which presented a yield of 4.75%. Among the 30 identified compounds, thymol (33.2%) was the major constituent, representing 97.8% of the total oil. The efficacy of both the oil and thymol standard (Sigma-Aldrich) was evaluated against S. frugiperda using topical acute toxicity and contact surface tests at different concentrations. The oil was more active than thymol standard, with topical acute toxicity of LD50 at 0.020 μl/insect and LC50 at 0.171 μl/cm2 for contact surface toxicity. The oil proved to be superior to the thymol standard, offering an effective and promising alternative for the control of S. frugiperda, which is most likely due to the contribution of other oil components that acted synergistically. Consequently, this result provides an opportunity for further study and the development of an effective fall armyworm control system.

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Essential Oils from Leaves of Medicinal Plants of Brazilian Flora: Chemical Composition and Activity against Candida Species

Cited by 25 publications

References 30 publications

Pathogenesis and Clinical Relevance of Candida Biofilms in Vulvovaginal Candidiasis

Pathogenesis and Clinical Relevance of Candida Biofilms in Vulvovaginal Candidiasis

Promising Alternative Therapeutics for Oral Candidiasis

Chemical analysis and insecticidal activity of Ocimum gratissimum essential oil and its major constituent against Spodoptera frugiperda (Smith, 1797) (Lepidoptera: Noctuidae)

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