Essential oils of the leaves of Syzygium cumini (L.) Skeels and fruit peels of Hymenaea courbaril (L.) var. courbaril as molluscides against Biomphalaria glabrata

Everton, Gustavo Oliveira; Júnior, Paulo Sérgio Santos; Sales, Everton Holanda; Rosa, Paulo Victor Serra; Dias, Andressa Almeida Santana; Duarte, Ricardo Victor Seguins; Souza, Laurilene dos Santos; Neto, Ari Pereira de Araújo; Souza, Lauriane dos Santos; Santos, Monyka Brito Lima dos; Lages, Maria Gizelda Gomes; Filho, Victor Elias Mouchrek

doi:10.33448/rsd-v9i10.8215

Cited by 3 publications

(4 citation statements)

References 45 publications

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“…It is important to note that there is a disparity in the results found in the literature, with different major compounds identified in EOSC. In addition to those previously mentioned, τ-cadinol (21.44%) [19], 5-methyl-1,3,6-heptatriene (4.90%) [22], isocaryophyllene (18.01%) [36], cis-β-ocimene (27.98%) [17], caryophyllene oxide (17.24%) [37], β-caryophyllene (37.65%) [38], and α-pinene (21.09%) [39] are also reported.…”

Section: Discussionmentioning

confidence: 79%

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In Vitro and In Silico Biological Evaluation of the Essential Oil from Syzigium cumini Leaves as a Source of Novel Antifungal and Trichomonacidal Agents

Silva,

Moreira,

Bezerra

et al. 2024

Future Pharmacology

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As microbes develop resistance to various drugs, the treatment of infections becomes increasingly challenging, leading to prolonged illness, heightened severity of infections, elevated mortality rates, and increased healthcare costs. Essential oils are lipophilic and volatile mixtures of compounds that have gained attention in research for novel antimicrobial agents. Therefore, the present study evaluated the essential oil of Syzygium cumini leaves (EOSC) in order to prospect its antifungal and trichomonacidal activities. The essential oil from the leaves was extracted by steam distillation and analyzed by GC-MS. Antifungal activity was evaluated using the serial microdilution method. Additionally, the potential of the EOSC as an enhancer of fluconazole (FCZ) action was tested at subinhibitory concentrations. To assess anti-Trichomonas vaginalis activity, concentrations ranging from 15.6 to 500 μg/mL of EOSC were tested. Finally, the SwissADME platform was employed to analyze the physicochemical and pharmacokinetic characteristics of the major component of EOSC. The GC-MS analysis identified 94.24% of the components of EOSC, with α-pinene (51.11%) and nerol (8.25%) as major constituents. EOSC exhibited low antifungal activity against the evaluated Candida strains. However, the combination of EOSC and FCZ reduced the IC50 against Candida krusei from 45.29 to 0.30 μg/mL. EOSC also demonstrated significant activity against T. vaginalis (IC50 = 88.2 μg/mL). In silico prediction with α-pinene showed low toxic action and important physicochemical aspects for drug production. The essential oil of Syzygium cumini emerges as a promising candidate for the discovery of molecules with potential antifungal and anti-Trichomonas vaginalis applications.

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Section: Discussionmentioning

confidence: 79%

“…The preference for treatments using S. cumini is acceptable given its proven low toxicity, as evidenced in the studies by Everton et al [36] and Everton et al [33]. These studies found that EOSC does not exhibit significant toxicity towards the model organism Artemia salina.…”

Section: Discussionmentioning

confidence: 99%

In Vitro and In Silico Biological Evaluation of the Essential Oil from Syzigium cumini Leaves as a Source of Novel Antifungal and Trichomonacidal Agents

Silva,

Moreira,

Bezerra

et al. 2024

Future Pharmacology

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“…Essential oils are included among the important classes of special metabolites that the various plant groups produce, thus presenting, in their composition, terpenic, diterpenic, sesquiterpenic and phenylpropanoid compounds, oxygenated or hydrocarbons, with a physiological purpose in the protection of the plant, as a means of attraction pollinators, as well as, for medicine, in important acetylcholinesterase inhibitors, with antifungal, antibacterial, antiviral, cytotoxic, allelopathic activities, among others (Everton et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Chemical, physicochemical profile and dose-response effect of Hymenaea courbaril essential oil on bacteria

et al. 2022

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Hymenaea courbaril is a tree species belonging to the genus Hymenaea and family Fabaceae. This study aimed to extract the essential oil from the fruit peel and evaluate the physicochemical characteristics and bacterial activity. The fruits were collected in the municipality of Santa Helena de Goiás, Goiás, Brasil. The bark was crushed and the powder obtained used in the extraction of the essential oil in the Clevenger-type system. The physical-chemical evaluation was performed for organoleptic analysis, refractive index, relative density, optical rotation and solubility in 70% hydroethanolic solution. The chemical profile was evaluated by gas chromatography with a coupled mass emitter. The antibacterial assay was performed in a Petri dish at different oil concentrations and the antibiosis halo (mm) when present was evaluated with the aid of a caliper. The essential oil of the peel of the fruit of H. courbaril was aromatic, clear, slightly aromatic, presenting physicochemical characteristics similar to the several essential oils of plants. It demonstrated a chemical profile rich in molecules and effective antibacterial action.

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“…Schistosomiasis mansoni has in its biological cycle the involvement of mollusks of the genus Biomphalaria, which are the only intermediate hosts, and has man as the definitive host. This disease is popularly known as "mollusks disease" and/or "water belly", which courses with an acute or chronic condition, often with few symptoms or asymptomatic, but can also manifest in more severe forms, with an outcome of the death of the host (Rocha et al, 2016;Everton et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Applicability of Euphorbia milii var splendens latex in the control of Biomphalaria tenagophila

Coêlho

Esteves

Bastos

et al. 2021

RSD

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The present work aimed to evaluate in vitro the molluscicidal activity and latex toxicity of Euphorbia milii var. splendens (Bojer ex Hook) Ursch & Leandri for the control of mollusks of the species Biomphalaria tenagophila. Specimens of E. milii var. splendens cultivated in the rural region of Pindamonhangaba were selected, from which latex was obtained by the transverse incision of the aerial parts. For the molluscicide test, adult mollusks of the species B. tenagophila were separated into groups of 10 and submitted to latex immersion at concentrations of 2.5 ppm, 1.25 ppm, 0.625 ppm, and 0.3125 ppm for 24 hours. In parallel, the toxicity of latex at a concentration of 0.3125 ppm was determined by testing with Artemia salina (mortality assessment) and using the Allium cepa test (determination of growth inhibition, amount, and weight of roots). It was observed an important molluscicidal activity of E. milii var. splendens latex at the various concentrations evaluated. In addition, it was also possible to observe moderate toxicity against A. salina nauplii and in the toxicity test with A. cepa. This demonstrates the potential of using latex from E. milii var. splendens to control populations of B. tenagophila species, not only for the observed molluscicidal activity but also for the moderate mortality of A. salina nauplii, whereas in the A. cepa test no change was observed in the parameters evaluated in relation to the control group, demonstrating safety for use in the environment.

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Essential oils of the leaves of Syzygium cumini (L.) Skeels and fruit peels of Hymenaea courbaril (L.) var. courbaril as molluscides against Biomphalaria glabrata

Cited by 3 publications

References 45 publications

In Vitro and In Silico Biological Evaluation of the Essential Oil from Syzigium cumini Leaves as a Source of Novel Antifungal and Trichomonacidal Agents

In Vitro and In Silico Biological Evaluation of the Essential Oil from Syzigium cumini Leaves as a Source of Novel Antifungal and Trichomonacidal Agents

Chemical, physicochemical profile and dose-response effect of Hymenaea courbaril essential oil on bacteria

Applicability of Euphorbia milii var splendens latex in the control of Biomphalaria tenagophila

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