Essential oils used in Modified Drug Delivery and its formulation of Liposomes for Topical Purpose

Singh, Aditya Pratap; Ansari, VA; Haider, Faheem; Akhtar, Jamal; Ahsan, Farogh

doi:10.5958/2321-5836.2020.00008.7

Cited by 10 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are various strategies for loading drugs into liposomes, which can overcome the early degradation and damage of drugs against the surrounding environment, so the stability of drugs is increased dramatically. As a result, liposomes can have many applications in the pharmaceutical industry, including: increasing the half‐life of the drug, drug protection, low toxicity, high biocompatibility and low immunogenicity 18–20 …”

Section: Introductionmentioning

confidence: 99%

“…increasing the half-life of the drug, drug protection, low toxicity, high biocompatibility and low immunogenicity. [18][19][20] The genetic targeting of the majority of pathway components in the PI3K/AKT pathway, which is more frequent than any other growth factor signaling pathway, often leads to its activation as a cancer driver in various types of cancers. 21 Numerous studies have shown that inhibitors of PI3K isoforms, AKT (AKT1, AKT2, and AKT3) activate the mammalian target of rapamycin (mTOR), and other pathway components for the treatment of melanoma cancer.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The anticancer impacts of free and liposomal caffeic acid phenethyl ester (CAPE) on melanoma cell line (A375)

Bahrami,

Farasat,

Zolghadr

et al. 2023

Cell Biochemistry & Function

View full text Add to dashboard Cite

The deadliest type of skin cancer, malignant melanoma, is also the reason for the majority of skin cancer‐related deaths. The objective of this article was to investigate the efficiency of free caffeic acid phenethyl ester (CAPE) and liposomal CAPE in inducing apoptosis in melanoma cells (A375) in in vitro. CAPE was loaded into liposomes made up of hydrogenated soybean phosphatidylcholine, cholesterol, and 1,2‐distearoyl‐sn‐glycero‐3 phosphoethanolamine‐N‐[methoxy (polyethylene glycol)‐2000], and their physicochemical properties were assessed. (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) test was performed for comparing the cytotoxicity of free CAPE and liposomal CAPE at dosages of 10, 15, 25, 50, 75 and the highest dose of 100 μg/mL for period of 24 and 48 h on A375 cell line to calculate IC50. Apoptosis and necrosis were evaluated in A375 melanoma cancer cells using flow cytometry. Atomic force microscopy was utilized to determine the nanomechanical attributes of the membrane structure of A375 cells. To determine whether there were any effects on apoptosis, the expression of PI3K/AKT1 and BAX/BCL2 genes was analyzed using the real‐time polymerase chain reaction technique. According to our results, the maximum amount of drug release from nanoliposomes was determined to be 91% and the encapsulation efficiency of CAPE in liposomes was 85.24%. Also, the release of free CAPE was assessed to be 97%. Compared with liposomal CAPE, free CAPE showed a greater effect on reducing the cancer cell survival after 24 and 48 h. Therefore, IC50 values of A375 cells treated with free and liposomal CAPE were calculated as 47.34 and 63.39 μg/mL for 24 h. After 48 h of incubation of A375 cells with free and liposomal CAPE, IC50 values were determined as 30.55 and 44.83 μg/mL, respectively. The flow cytometry analysis revealed that the apoptosis induced in A375 cancer cells was greater when treated with free CAPE than when treated with liposomal CAPE. The highest nanomechanical changes in the amount of cell adhesion forces, and elastic modulus value were seen in free CAPE. Subsequently, the greatest decrease in PI3K/AKT1 gene expression ratio occurred in free CAPE.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The anticancer impacts of free and liposomal caffeic acid phenethyl ester (CAPE) on melanoma cell line (A375)

Bahrami,

Farasat,

Zolghadr

et al. 2023

Cell Biochemistry & Function

View full text Add to dashboard Cite

show abstract

“…There are a wide range of applications in the medical field due to nanoencapsulation technology and the benefits that liposomes can offer: increased efficacy, high biocompatibility, low immunogenicity, drug protection, prolonged half-life of the drug, and low toxicity [23]. The use of liposomes in topical applications also has the advantage that it can reduce local irritation [24].…”

Section: Introductionmentioning

confidence: 99%

Liposomes with Caffeic Acid: Morphological and Structural Characterisation, Their Properties and Stability in Time

et al. 2021

View full text Add to dashboard Cite

Medical and pharmaceutical research has shown that liposomes are very efficient in transporting drugs to targets. In this study, we prepared six liposome formulas, three in which we entrapped caffeic acid (CA), and three with only phospholipids and without CA. Determination of entrapment efficiency (EE) showed that regardless of the phospholipids used, the percentage of CA entrapment was up to 76%. The characterization of the liposomes was performed using Dynamic Light Scattering (DLS), Atomic Force Microscopy (AFM), zeta potential and polydispersity and showed that about 75–99% of the liposomes had dimensions between 40 ± 0.55–500 ± 1.45 nm. The size and zeta potential of liposomes were influenced by the type of phospholipid used to obtain them. CA release from liposomes was performed using a six-cell Franz diffusion system, and it was observed that the release of entrapped CA occurs gradually, the highest amount occurring in the first eight hours (over 80%), after which the release is much reduced. Additionally, the time stability of the obtained liposomes was analysed using univariate and multivariate statistical analysis. Therefore, liposomes offer great potential in CA entrapment.

show abstract

Emerging Nanotechnology for the Treatment of Alzheimer’s Disease

Ansari

Singh

Mahmood

et al. 2024

CNSNDDT

View full text Add to dashboard Cite

Nanotechnology is a great choice for medical research, and the green synthesis approach is a novel and better way to synthesize nanoparticles. Biological sources are cost-effective, environmentally friendly, and allow large-scale production of nanoparticles. Naturally obtained 3 β-hydroxy-urs-12-en-28-oic acids reported for neuroprotective and dendritic structure are reported as solubility enhancers. Plants are free from toxic substances and act as natural capping agents. In this review, the pharmacological properties of ursolic acid (UA) and the structural properties of the dendritic structure are discussed. UA acid appears to have negligible toxicity and immunogenicity, as well as favorable biodistribution, according to the current study, and the dendritic structure improves drug solubility, prevents drug degradation, increases circulation time, and potentially targets by using different pathways with different routes of administration. Nanotechnology is a field in which materials are synthesized at the nanoscale. Nanotechnology could be the next frontier of humankind's technological advancement. Richard Feynman first used the term ‘Nanotechnology’ in his lecture, “There is Plenty of Room at the Bottom,” on 29th December, 1959, and since then, interest has increased in the research on nanoparticles. Nanotechnology is capable of helping humanity by solving major challenges, particularly in neurological disorders like Alzheimer's disease (AD), the most prevalent type, which may account for 60–70% of cases. Other significant forms of dementia include vascular dementia, dementia with Lewy bodies (abnormal protein aggregates that form inside nerve cells), and a number of illnesses that exacerbate frontotemporal dementia. Dementia is an acquired loss of cognition in several cognitive domains that are severe enough to interfere with social or professional functioning. However, dementia frequently co-occurs with other neuropathologies, typically AD with cerebrovascular dysfunction. Clinical presentations show that neurodegenerative diseases are often incurable because patients permanently lose some neurons. A growing body of research suggests that they also advance our knowledge of the processes that are probably crucial for maintaining the health and functionality of the brain. Serious neurological impairment and neuronal death are the main features of neurodegenerative illnesses, which are also extremely crippling ailments. The most prevalent neurodegenerative disorders cause cognitive impairment and dementia, and as average life expectancy rises globally, their effects become more noticeable.

show abstract

Essential oils used in Modified Drug Delivery and its formulation of Liposomes for Topical Purpose

Cited by 10 publications

References 0 publications

The anticancer impacts of free and liposomal caffeic acid phenethyl ester (CAPE) on melanoma cell line (A375)

The anticancer impacts of free and liposomal caffeic acid phenethyl ester (CAPE) on melanoma cell line (A375)

Liposomes with Caffeic Acid: Morphological and Structural Characterisation, Their Properties and Stability in Time

Emerging Nanotechnology for the Treatment of Alzheimer’s Disease

Contact Info

Product

Resources

About