2008
DOI: 10.1016/j.imbio.2007.12.002
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Essential role of IFNβ and CD38 in TNFα-induced airway smooth muscle hyper-responsiveness

Abstract: We recently identified autocrine interferon (IFN)β as a novel mechanism mediating tumor necrosis factor (TNF)α-induced expression of inflammatory genes in airway smooth muscle (ASM) cells, including CD38, known to regulate calcium signaling. Here, we investigated the putative involvement of IFNβ in regulating TNFα-induced airway hyper-responsiveness (AHR), a defining feature of asthma. Using our pharmacodynamic model to assess ex vivo AHR isolated murine tracheal rings, we found that TNFα-induced enhanced cont… Show more

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Cited by 34 publications
(26 citation statements)
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“…KBP12.6 overexpression prevented the decrease in the association of FKBP12.6 with RyR2 induced by asthmatic serum (Figures 4C and 4D) and by IL-5, IL-13, and TNF-a ( Figures 4E and 4F), indicating that the decrease in the association of FKBP12.6 with RyR2 induced by asthmatic serum, IL-5, IL-13, and TNF-a is caused by a decrease in FKBP12. 6 5A and 5B) and with IL-5, IL-13, and TNF-a ( Figures 5C and 5D). These results indicate that asthmatic serum-, IL-5-, IL-13-, and TNF-a-induced decrease in the association of FKBP12.6 with RyR2 is responsible for the increase in calcium response of BSMCs to bradykinin.…”
Section: Fkbp126 Knockdown Enhances Calcium Response Of Bsmcs To Bramentioning
confidence: 91%
“…KBP12.6 overexpression prevented the decrease in the association of FKBP12.6 with RyR2 induced by asthmatic serum (Figures 4C and 4D) and by IL-5, IL-13, and TNF-a ( Figures 4E and 4F), indicating that the decrease in the association of FKBP12.6 with RyR2 induced by asthmatic serum, IL-5, IL-13, and TNF-a is caused by a decrease in FKBP12. 6 5A and 5B) and with IL-5, IL-13, and TNF-a ( Figures 5C and 5D). These results indicate that asthmatic serum-, IL-5-, IL-13-, and TNF-a-induced decrease in the association of FKBP12.6 with RyR2 is responsible for the increase in calcium response of BSMCs to bradykinin.…”
Section: Fkbp126 Knockdown Enhances Calcium Response Of Bsmcs To Bramentioning
confidence: 91%
“…Airway hyperresponsiveness to aerosolized acetyl-β-methylcholine chloride methacholine (MCh) inhalation was assessed using the FlexiVent system (SCIREQ, Montreal, Canada) as described before 23 . Briefly, lung mechanics were studied in tracheostomized mice under anesthesia by intra-peritoneal injection of ketamine and xylazine.…”
Section: Methodsmentioning
confidence: 99%
“…A classic example is tumor necrosis factor (TNF) a, which has been shown to increase ASM contractility to the spasmogens histamine, leukotriene D 4 , bradykinin, des-Arg 9 -bradykinin, serotonin, neurokinin A, the tromboxane A 2 analog U46619, and the muscarinic agonists acetylcholine, methacholine, and carbachol. TNFa is actually used by a few groups as an ex vivo model of AHR [24,25]. IL-1b is another classic example of a molecule shown to increase ASM contractility to several spasmogens, such as bradykinin, des-Arg 9 -bradykinin, substance P, serotonin, neurokinin A, and the muscarinic agonists acetylcholine and methacholine.…”
Section: Opinionmentioning
confidence: 99%