1985
DOI: 10.1016/s0140-6736(85)92313-x
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Essential Role of Post-Heparin Lipoprotein Lipase Activity and of Plasma Testosterone in Coronary Artery Disease

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Cited by 82 publications
(22 citation statements)
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“…158 Third, in an angiographic study, the severity of coronary artery disease was found to be negatively correlated more strongly with postheparin LPL activity than with HDL cholesterol. 164 This result was consonant with previous reports dating from the 1950s showing that the rate of clearance of plasma turbidity after intravenous heparin given postprandialry was lower in CHD cases than in healthy controls. 168166 These early observations were made before LPL had been discovered 187 and at a time when the clarifying effect of heparin was thought to reflect a change in the physical state of plasma lipids.…”
Section: Clinical Disorders Of High Density Upoproteln Metabolismsupporting
confidence: 90%
“…158 Third, in an angiographic study, the severity of coronary artery disease was found to be negatively correlated more strongly with postheparin LPL activity than with HDL cholesterol. 164 This result was consonant with previous reports dating from the 1950s showing that the rate of clearance of plasma turbidity after intravenous heparin given postprandialry was lower in CHD cases than in healthy controls. 168166 These early observations were made before LPL had been discovered 187 and at a time when the clarifying effect of heparin was thought to reflect a change in the physical state of plasma lipids.…”
Section: Clinical Disorders Of High Density Upoproteln Metabolismsupporting
confidence: 90%
“…Misclassification 19 In nearly all case-control studies4-7,9,13,14,16-20 that measured testosterone, and in the prospective Multiple Risk Factor Intervention Trial,2' testosterone levels were lower in men with ischemic heart disease, although, as in the present study, differences were not always statistically significant. Although the present study, like its predecessors, does not completely resolve the question of whether endogenous gonadal hormones are related to cardiovascular disease risk in men, these data make it increasingly unlikely that higher plasma estrogens are causally related to cardiovascular disease in older men.…”
Section: Discussioncontrasting
confidence: 48%
“…19 Previous clinical study have shown that post-heparin plasma LPL activity is decreased in hypertriglyceridemic subjects and has a strongly positive relation to the HDL-C level. 20,21 The present study revealed a negative correlation between preheparin LPL mass and TG and a positive correlation with HDL-C (Fig 2), which is consistent with reports by Tronvall et al 22 and Watanabe et al, 23 and suggests that preheparin LPL mass reflects the level of functioning LPL activity in vivo, even though lipase activity is not detected.…”
Section: Preheparin Lpl Mass and Lpl Activitysupporting
confidence: 93%