Essential Role of STAT3 Signaling in Hair Follicle Homeostasis

Miyauchi, Katsumi; Ki, Sewon; Ukai, Masao; Suzuki, Yasufumi; Inoue, Kentaro; Suda, Wataru; Matsui, Toshinori; Ito, Yoshihiro; Honda, Kenya; Koseki, Haruhiko; Ohara, Osamu; Tanaka, Reiko; Okada‐Hatakeyama, Mariko; Kubo, Masato

doi:10.3389/fimmu.2021.663177

Cited by 10 publications

(4 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the specific targeting of STAT3 has been challenging. This is particularly critical since STAT3 signaling is also essential in hair follicle and bone homeostasis [ 24 , 25 ]. siRNAs, used for the specific down-regulation of targeted genes, have garnered considerable interest as an attractive new class of drugs for a broad range of clinical applications [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Specific Targeting of STAT3 in B Cells Suppresses Progression of B Cell Lymphoma

Wang,

Zhou,

Kong

et al. 2023

IJMS

View full text Add to dashboard Cite

The signal transducer and activator of transcription 3 (STAT3), which regulates multiple oncogenic processes, has been found to be constitutively activated in lymphoma, suggesting its potential as a therapeutic target. Here, we constructed an anti-CD19-N-(4-carboxycyclohexylmethyl) maleimide N-hydroxysuccinimide ester (SMCC)-protamine (CSP)-STAT3 small interfering RNA (siRNA) conjugate and demonstrated that the CSP-STAT3 siRNA conjugate could specifically bind to normal B cells and A20 lymphoma cells in vitro. It decreased the STAT3 expression in B cell lymphoma cell lines (A20, SU-DHL-2 and OCI-Ly3), resulting in reduced proliferation of lymphoma cells featured with lower S-phase and higher apoptosis. Using an A20 transplantable lymphoma model, we found that the CSP-STAT3 siRNA conjugate significantly inhibited tumor growth and weight. Ki-67, p-STAT3, STAT3, and serum IL-6 levels were all significantly reduced in A20-bearing mice treated with CSP-STAT3 siRNA. These findings indicate that specifically targeting STAT3 siRNA to B cell lymphoma cell lines can significantly decrease STAT3 activity and inhibit tumor progression in vitro and in vivo, suggesting its potential utilization for cancer treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Specific Targeting of STAT3 in B Cells Suppresses Progression of B Cell Lymphoma

Wang,

Zhou,

Kong

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…STAT-3 mutation determined in mice has been indicative of telogen to anagen phase obstruction; pointing that STAT-3 expression in basal keratinocytes through anti-EGFR treatment may give strong evidence of hypertrichosis onset. 14,19 Promising basic research information implicating EGFR, FGF, and STAT-3 with a majority of skin cutaneous hair morphogenesis and multistep transformation giving strong evidence of possible interactive mechanisms of undesirable documented events. So publishing distinct cases combined with EGFR manipulation undoubtedly will focus on a challenging era hinting uninvestigated drug-induced mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Pinnae and facial hypertrichosis induced by cetuximab

Alexandris

Alevizopoulos

Palamaris

et al. 2022

J Oncol Pharm Pract

View full text Add to dashboard Cite

Introduction Anti-EGFR targeted anti-cancer treatment is associated with various skin adverse events. Cetuximab is often associated with acneiform papules and skin disorders. Hypertrichosis cited in face pinnae and eyelash trichomegaly are seldom described. Case report A 72-year-old female cancer patient presented deteriorating facial-pinnae hypertrichosis and eyelash prolongation post cetuximab infusion. Management and outcome Consecutive cetuximab administration led to exaggerating hairy skin side effects, fully alleviated when the drug was discontinued. Discussion To the best of our knowledge, this is the first reported case of an anti-EGFR-associated diffuse pinnae hypertrichosis presentation in a female patient in literature. This distinct entity can be easily diagnosed and manipulated with early drug withdrawal. An extensive review of relevant basic molecular research is provided to increase physicians’ awareness.

show abstract

“…STAT3 (Signal Transducer and Activator of Transcription 3) is activated by cytokines and growth factors. This gene plays an important role in maintaining the homeosis of skin (48). STAT5A (Signal Transducer and Activator of Transcription 5A) protein serves a dual function of signal transduction and activation of transcription in cells exposed to cytokine and other growth factors.…”

Section: Candidate Genes In Aga Pathologymentioning

confidence: 99%

Bioinformatic analysis of gene expression data reveals Src family protein tyrosine kinases as key players in androgenetic alopecia

Premanand

Rajkumari

2023

Front. Med.

View full text Add to dashboard Cite

IntroductionAndrogenetic alopecia (AGA) is a common progressive scalp hair loss disorder that leads to baldness. This study aimed to identify core genes and pathways involved in premature AGA through an in-silico approach.MethodsGene expression data (GSE90594) from vertex scalps of men with premature AGA and men without pattern hair loss was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) between the bald and haired samples were identified using the limma package in R. Gene ontology and Reactome pathway enrichment analyses were conducted separately for the up-regulated and down-regulated genes. The DEGs were annotated with the AGA risk loci, and motif analysis in the promoters of the DEGs was also carried out. STRING Protein-protein interaction (PPI) and Reactome Functional Interaction (FI) networks were constructed using the DEGs, and the networks were analyzed to identify hub genes that play could play crucial roles in AGA pathogenesis.Results and discussionThe in-silico study revealed that genes involved in the structural makeup of the skin epidermis, hair follicle development, and hair cycle are down-regulated, while genes associated with the innate and adaptive immune systems, cytokine signaling, and interferon signaling pathways are up-regulated in the balding scalps of AGA. The PPI and FI network analyses identified 25 hub genes namely CTNNB1, EGF, GNAI3, NRAS, BTK, ESR1, HCK, ITGB7, LCK, LCP2, LYN, PDGFRB, PIK3CD, PTPN6, RAC2, SPI1, STAT3, STAT5A, VAV1, PSMB8, HLA-A, HLA-F, HLA-E, IRF4, and ITGAM that play crucial roles in AGA pathogenesis. The study also implicates that Src family tyrosine kinase genes such as LCK, and LYN in the up-regulation of the inflammatory process in the balding scalps of AGA highlighting their potential as therapeutic targets for future investigations.

show abstract

Essential Role of STAT3 Signaling in Hair Follicle Homeostasis

Cited by 10 publications

References 50 publications

Specific Targeting of STAT3 in B Cells Suppresses Progression of B Cell Lymphoma

Specific Targeting of STAT3 in B Cells Suppresses Progression of B Cell Lymphoma

Pinnae and facial hypertrichosis induced by cetuximab

Bioinformatic analysis of gene expression data reveals Src family protein tyrosine kinases as key players in androgenetic alopecia

Contact Info

Product

Resources

About