Essential role of Swp73p in the function of yeast Swi/Snf complex.

Cairns, Bradley R.; Levinson, Randy; Yamamoto, Keith R.; Kornberg, Roger D.

doi:10.1101/gad.10.17.2131

Cited by 115 publications

(77 citation statements)

References 55 publications

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“…Specifically, Snf12p is a subunit of the SWI/SNF complex that regulates transcription of the SUC2 and HO endonuclease genes as well as other genes. (Cairns et al 1996a). Rsc6p is a subunit of the related Rsc complex that regulates transcription of ribosomal protein genes as well as other genes (Cairns et al 1996b;Angus-Hill et al 2001).…”

Section: Resultsmentioning

confidence: 99%

Conserved Functions of Yeast Genes Support the Duplication, Degeneration and Complementation Model for Gene Duplication

Hoof

2005

Genetics

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Gene duplication is often cited as a potential mechanism for the evolution of new traits, but this hypothesis has not been thoroughly tested experimentally. A classical model of gene duplication states that after gene duplication one copy of the gene preserves the ancestral function, while the other copy is free to evolve a new function. In an alternative duplication, divergence, and complementation model, duplicated genes are preserved because each copy of the gene loses some, but not all, of its functions through degenerating mutations. This results in the degenerating mutations in one gene being complemented by the other and vice versa. These two models make very different predictions about the function of the preduplication orthologs in closely related species. These predictions have been tested here for several duplicated yeast genes that appeared to be the leading candidates to fit the classical model. Surprisingly, the results show that duplicated genes are maintained because each copy carries out a subset of the conserved functions that were already present in the preduplication gene. Therefore, the results are not consistent with the classical model, but instead fit the duplication, divergence, and complementation model.

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Section: Resultsmentioning

confidence: 99%

Conserved Functions of Yeast Genes Support the Duplication, Degeneration and Complementation Model for Gene Duplication

Hoof

2005

Genetics

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“…In yeast (Saccharomyces cerevisiae), the SWP73 protein is obligatory during growth at elevated temperature (Cairns et al, 1996). In mammals, selective incorporation of three BAF60 variants into SWI/SNF complexes directs lineage-specific cell differentiation, which is the best documented in muscle differentiation.…”

Section: Introductionmentioning

confidence: 99%

SWP73 Subunits of Arabidopsis SWI/SNF Chromatin Remodeling Complexes Play Distinct Roles in Leaf and Flower Development

et al. 2015

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(T.J.S.)Arabidopsis thaliana SWP73A and SWP73B are homologs of mammalian BRAHMA-associated factors (BAF60s) that tether SWITCH/SUCROSE NONFERMENTING chromatin remodeling complexes to transcription factors of genes regulating various cell differentiation pathways. Here, we show that Arabidopsis thaliana SWP73s modulate several important developmental pathways. While undergoing normal vegetative development, swp73a mutants display reduced expression of FLOWERING LOCUS C and early flowering in short days. By contrast, swp73b mutants are characterized by retarded growth, severe defects in leaf and flower development, delayed flowering, and male sterility. MNase-Seq, transcript profiling, and ChIP-Seq studies demonstrate that SWP73B binds the promoters of ASYMMETRIC LEAVES1 and 2, KANADI1 and 3, and YABBY2, 3, and 5 genes, which regulate leaf development and show coordinately altered transcription in swp73b plants. Lack of SWP73B alters the expression patterns of APETALA1, APETALA3, and the MADS box gene AGL24, whereas other floral organ identity genes show reduced expression correlating with defects in flower development. Consistently, SWP73B binds to the promoter regions of APETALA1 and 3, SEPALLATA3, LEAFY, UNUSUAL FLORAL ORGANS, TERMINAL FLOWER1, AGAMOUS-LIKE24, and SUPPRESSOR OF CONSTANS OVEREXPRESSION1 genes, and the swp73b mutation alters nucleosome occupancy on most of these loci. In conclusion, SWP73B acts as important modulator of major developmental pathways, while SWP73A functions in flowering time control.

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“…This prompted us to investigate the function of another putative subunit of SWI/SNF complexes in the control of flowering. The SWP73 component of the yeast (Saccharomyces cerevisiae) SWI/SNF complex has a functional role in transcriptional activation (Cairns et al, 1996). Orthologs of SWP73, called BAP60 in Drosophila melanogaster and BAF60 in human, have been extensively characterized biochemically and genetically (Tang et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

The BAF60 Subunit of the SWI/SNF Chromatin-Remodeling Complex Directly Controls the Formation of a Gene Loop at FLOWERING LOCUS C in Arabidopsis

et al. 2014

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SWI/SNF complexes mediate ATP-dependent chromatin remodeling to regulate gene expression. Many components of these complexes are evolutionarily conserved, and several subunits of Arabidopsis thaliana SWI/SNF complexes are involved in the control of flowering, a process that depends on the floral repressor FLOWERING LOCUS C (FLC). BAF60 is a SWI/SNF subunit, and in this work, we show that BAF60, via a direct targeting of the floral repressor FLC, induces a change at the highorder chromatin level and represses the photoperiod flowering pathway in Arabidopsis. BAF60 accumulates in the nucleus and controls the formation of the FLC gene loop by modulation of histone density, composition, and posttranslational modification. Physiological analysis of BAF60 RNA interference mutant lines allowed us to propose that this chromatinremodeling protein creates a repressive chromatin configuration at the FLC locus.

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Essential role of Swp73p in the function of yeast Swi/Snf complex.

Cited by 115 publications

References 55 publications

Conserved Functions of Yeast Genes Support the Duplication, Degeneration and Complementation Model for Gene Duplication

Conserved Functions of Yeast Genes Support the Duplication, Degeneration and Complementation Model for Gene Duplication

SWP73 Subunits of Arabidopsis SWI/SNF Chromatin Remodeling Complexes Play Distinct Roles in Leaf and Flower Development

The BAF60 Subunit of the SWI/SNF Chromatin-Remodeling Complex Directly Controls the Formation of a Gene Loop at FLOWERING LOCUS C in Arabidopsis

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