Essential role of ultraviolet radiation in the decrease of corneal endothelial cell density caused by pterygium

Li, Xia; Dai, Yiqin; Xu, Weiwei; Xu, Jianjiang

doi:10.1038/s41433-018-0188-y

Cited by 14 publications

(20 citation statements)

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“…However, the results of our study came to a different conclusion. The ECD decrease in eyes with pterygium from our retrospective study was far less (76 cells/mm 2 , 3.1%) than those in the previous studies [11, 13, 15]. In our retrospective study, the ECD of eyes with unilateral pterygium was almost the same as the ECD of the contralateral eyes.…”

Section: Discussioncontrasting

confidence: 57%

“…In a previous study, outdoor workers with more UV radiation exposure was shown to have lower ECD compared to non-outdoor workers [19]. In a recent study, ECD decrease in eyes with pterygium was also found to be associated with the duration of UV radiation exposure [15]. The other cause of ECD decrease in eyes with pterygium is a variety of pathogenic factors including inflammation, angiogenesis and extracellular matrix modulators [9].…”

Section: Discussionmentioning

confidence: 99%

“…However, in patients with short UV exposure the ECD was not significantly different between the eyes with pterygium and the contralateral eyes. Moreover, patients with longer UV exposure had significantly lower ECD than patients with short UV exposure [15]. It appeared that in eyes with pterygium the UV exposure needed to reach a certain threshold to induce ECD decrease.…”

Section: Discussionmentioning

confidence: 99%

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Primary pterygium was not associated with corneal endothelial cell decrease in a rural Chinese population

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21 Purpose: To investigate the corneal endothelial cell density (ECD) in eyes 22 with primary pterygium.23 Methods: We first conducted a retrospective study to compare the ECD 24 between 1670 eyes with primary pterygium and 4060 eyes without pterygium. 25 Then we designed a prospective study to confirm the critical findings of the 26 retrospective study in 95 patients with unilateral primary pterygium.27 Results: In the retrospective study, the mean preoperative ECD in eyes with 28 primary ptergyium (2453±306 cells/mm 2 ) was statistically significantly lower 29 than those in eyes without pterygium (2529±313 cells/mm 2 , P<0.0001). 30 However, the difference was minor (76 cells/mm 2 , 3.1%). In the prospective 31 study, the mean ECD in eyes with unilateral primary pterygium (2480±263 32 cells/mm 2 ) was not significantly different from those in the contralateral eyes 33 (2527±277 cells/mm 2 , P=0.20). The hexagonality (P=0.10) or coefficient of 34 variation of size (P=0.15) of corneal endothelial cells was not significantly 35 different between eyes with pterygium and the contralateral eyes.36 Conclusion: Primary pterygium may not be associated with ECD decrease 37 in our study cohort. 38 Keywords: pterygium; corneal endothelial cell density; repeatability; 39 ultraviolet radiation 7 120 between patients in the PT group and those in the NPT group, or among 121 patients with bilateral pterygium, unilateral pterygium or without pterygium 122 (P>0.05). 123 The mean age of the patients (40 males and 55 females) in the 124 prospective study was 63.7±8.8 years. Forty-nine patients had pterygium in 125 the right eyes and 45 patients had pterygium in the left eye.126 ECD in the retrospective study 127 The mean preoperative ECD in the PT group (2453±306 cells/mm 2 ) 128 was statistically significantly lower than those in the NPT group (2529±313 129 cells/mm 2 , P<0.0001). The difference in ECD between the PT group and the 130 NPT group was 76 cells/mm 2 (3.1%). There was statistically significant 131 difference in preoperative ECD among patients with bilateral pterygium 132 (2444±329 cells/mm 2 ), unilateral pterygium (2486±309 cells/mm 2 ) or without 133 pterygium (2535±303 cells/mm 2 , P=0.001). In subgroup analysis, patients 134 with bilateral pterygium had lower ECD than patients without pterygium (91 135 cells/mm 2 , 3.7%, P=0.01). However, in patients with unilateral pterygium, the 136 ECD of the pterygium eyes (2487±313 cells/mm 2 ) was very similar to the 137 ECD of the contralateral eyes (2486±306 cells/mm 2 , P=0.99). The similar 138 ECD in both eyes of patients with unilateral pterygium raised our suspect 139 that ECD might not be decreased in eyes with pterygium in our population. 157 158 Discussion 9 159Pterygium is commonly seen in areas within the "pterygium zone" and 160 in people with outdoor occupations [1][2][3][4]. In our retrospective study, 29.1% 161(1670/5730) of eyes underwent cataract surgery had concomitant pterygium. 162Pterygium may cause corneal surface irregularity and astigmatism [5][6]....

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Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary pterygium was not associated with corneal endothelial cell decrease in a rural Chinese population

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“…13, 18 Our retrospective study results demonstrated that the ECD of eyes with unilateral pterygium was almost the same as the ECD of the contralateral normal eyes. Our prospective study showed that ECC hexagonality and ECV in eyes with unilateral PT was also not significantly different from those in the contralateral NPT eyes.…”

mentioning

confidence: 60%

“…Moreover, patients with longer UV exposure had significantly lower overall ECD than patients with short UV exposure. 18 These results suggest that in eyes with pterygium, UV exposure needs to reach a certain threshold to induce ECD decrease. One limitation of our study is that the UV exposure of patients was not recorded.…”

mentioning

confidence: 83%

Primary pterygium is not associated with corneal endothelial cell decrease in a rural Chinese population

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et al. 2019

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Purpose: To investigate corneal endothelial cell density (ECD) in eyes with primary pterygium. Methods: We first conducted a retrospective study to compare the ECD between 1670 eyes with primary pterygium and 4060 eyes without pterygium. Then we designed a prospective study to confirm the findings of our retrospective study in 95 patients with unilateral primary pterygium. Results: In the retrospective study, the mean ECD in eyes with primary pterygium (2453±306 cells/mm2) was significantly lower than those in eyes without pterygium (2529±313 cells/mm2, P<0.0001). However, the difference was not as high as previously reported (76 cells/mm2, 3.1%). In the prospective study, there was no significant difference in mean ECD in eyes with unilateral primary pterygium (2480±263 cells/mm2) and the contralateral eyes with no pterygium (2527±277 cells/mm2, P=0.20). There was also no significant difference in hexagonality (P=0.10) or coefficient of variation of size (P=0.15) of corneal endothelial cells between eyes with pterygium and the contralateral eyes with no pterygium. Conclusion: Primary pterygium may not be associated with a decrease in ECD in our study population of rural Chinese patients.

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Epidemiologic study of pterygium in Taiwan

et al. 2019

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Essential role of ultraviolet radiation in the decrease of corneal endothelial cell density caused by pterygium

Abstract: UV radiation exposure played a significant role in the effect of pterygium decreasing the corneal ECD.

Cited by 14 publications

References 32 publications

Primary pterygium was not associated with corneal endothelial cell decrease in a rural Chinese population

Primary pterygium was not associated with corneal endothelial cell decrease in a rural Chinese population

Primary pterygium is not associated with corneal endothelial cell decrease in a rural Chinese population

Epidemiologic study of pterygium in Taiwan

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