Essential thrombocythemia

JAK2 V617F Gene Mutation in the Laboratory Work-Up of Myeloproliferative Disorders: Experience of a Major Referral Center in Lebanon

“…This type of mutation was detected in 20% of the V617F negative cases, and most of the exon12 positive cases belonged to the patients with IE (Martínez-Avilés et al, 2007). In patients presenting an elevated platelet count and expected to have ET, it is important to exclude long-lasting reactive thrombocytosis to confirm ET (Brière, 2007). Thrombocytosis is a common finding but it poses a difficult diagnostic challenge.…”

Role of therapeutic apheresis in pediatric disorders

“…[23] Patients having count more than 1,000,000/µL may develop thrombotic or hemorrhagic complications. [24] During apheresis procedure the platelet count can be decreased as much as one third to one-half the initial value. The procedure can be repeated as frequently as necessary until drug therapy becomes effective and symptoms disappear.…”

Inhibition of blood platelet adhesion, aggregation and secretion by Artemisia dracunculus leaves extracts

“…Thrombus of large arteries is associated with severe neurological, cardiac and peripheral disabilities and therefore, it is followed by a large number of mortality (Briere, 2007). Platelet hyperactivity is one the most important factors responsible for arterial thrombosis and atherosclerosis (Olas et al, 2005).…”