Essential Thrombocytosis-Associated Thromboembolism in the Abdominal Aorta

Abstract

Essential thrombocytosis (ET) is a myeloproliferative disorder characterized by an anomalous increase in platelet production. Many patients with ET are asymptomatic. Few studies have reported ET-associated thromboembolism in large vessels such as the aorta. We report a patient with ET who presented with peripheral embolism from an abdominal aortic thrombus and developed acute limb ischemia. The patient underwent aortic replacement successfully. The patient’s platelet count was controlled with hydroxyurea, and no recurrence was noted over 2 years of follow-up.

Acute Occlusion of Right Femoral Artery Resulting in Gangrene of Right Leg Due to Essential Thrombocythemia and Atherosclerosis in COVID-19 era: A Case Report

“…Nevertheless, there were reports on essential thrombocythemia producing thrombosis of aorta [15][16][17]. In this case, combination of hypertension, smoking, severe atherosclerosis and essential thrombocythemia gave rise to extensive thrombosis of aorta; the rare variety of this case.…”

Two effective cases of additional pedal artery angioplasty for severe lower limb ischemia following acute thrombotic artery occlusion with hypercoagulable state diseases

“…Catheter-directed thrombolysis, which is directly delivered within the thrombus in femoropopliteal lesions, is also a feasible treatment for ALI patients (Byrne et al 2014 ). These treatment strategies had been adapted in ALI patients associated with hypercoagulable state diseases in previous reports (Moulinet et al 2016 ; Chong et al 2016 ; Morata Barrado et al 2009 ). However, high thrombus burden associated with hypercoagulable state disease in ALI patients might deteriorate the vascular bed, increase peripheral artery resistance, and lead to poor pedal outflow.…”

“…A rare potential cause of ALI includes thrombotic artery occlusion associated with hypercoagulable state diseases, such as antiphospholipid syndrome (APS) and essential thrombocythemia (ET) (Suzuki et al 2016 ; Moulinet et al 2016 ; Chong et al 2016 ; Morata Barrado et al 2009 ). Successful revascularisation, including thrombectomy, bypass surgery, endovascular treatment, or hybrid treatment (surgical revascularization and endovascular treatment) for thrombotic artery occlusion in hypercoagulable state patients, has been reported (Moulinet et al 2016 ; Chong et al 2016 ; Morata Barrado et al 2009 ). However, revascularization in infrapopliteal lesions, including below-the-ankle (BTA) lesions, may be difficult because of poor run-off vessels, and elevated peripheral vascular resistance associated with microcirculation failure, due to a high thrombus burden.…”

Incidental descending thoracic aortic thrombus: the conundrum of medical versus surgical therapy

“…A mural aortic thrombus is not encountered frequently in clinical practice and is in fact rare to diagnose prior to distal embolic complications, making the true incidence not well known. [1] Hematological disorders and states leading to hypercoagulability have been considered the main causes of aortic thrombi formation [2,3]. Though the complete mechanism of a direct mural aortic thrombus has not been fully explained, the state of hypercoagulability, stasis of blood flow, and endothelial injury (as expressed in Virchow's triad) appear to play a significant role.…”