Essential trace element alterations in amyotrophic lateral sclerosis

“…Trace elements have been implicated in the pathogenesis of the ALS for a long time. Because the new evidence has connected familial ALS with the metalloenzyme copper-zinc-manganese superoxide dismutases, the studies of their metabolism are being reinforced now [30]. In the central nervous system, zinc is highly localized in the cerebral cortex and hippocampus [31].…”

Section: Discussionmentioning

confidence: 99%

“…Mn toxicity induces parkinsonism in humans and has been associated with ALS-PD syndrome [30]. Zn, Cu and Mn play a crucial role in the activity of Cu/Zn SOD1, an enzyme that catalyses the conversion of toxic superoxide radicals to hydrogen peroxide and oxygen.…”

Section: Discussionmentioning

confidence: 99%

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Implementation of X-ray Fluorescence Microscopy for Investigation of Elemental Abnormalities in Amyotrophic Lateral Sclerosis

Tomik

Chwiej

Szczerbowska-Boruchowska

et al. 2006

Neurochem Res

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The abnormalities of metallochemical reactions may contribute to the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). In the present work, an investigation of the elemental composition of the gray matter, nerve cells and white matter from spinal cord tissues representing three ALS cases and five non-ALS controls was performed. This was done with the use of the synchrotron microbeam X-ray fluorescence technique (micro-SRXRF). The following elements were detected in the tissue sections: P, S, Cl, K, Ca, Fe, Cu, Zn and Br. A higher accumulation of Cl, K, Ca, Zn and Br was observed in the nerve cell bodies than in the surrounding tissue. Contrary to all other elements, Zn accumulation was lower in the white matter areas than in the gray matter ones. The results of quantitative analysis showed that there were no general abnormalities in the elemental accumulation between the ALS and the control group. However, for individual ALS cases such abnormalities were observed for the nerve cells. We also demonstrated differences in the elemental accumulation between the analyzed ALS cases.

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“…For the predominant, sporadic form of ALS, an imbalance in trace metal ions, possibly tied to increased oxidative stress, has been considered for some time. Recent studies provide evidence for decreases in copper in the cerebrospinal fluid and serum as well as increases in manganese in serum of diseased individuals compared to age-matched control [56].…”

Section: Cuznsod Mutations and Familial Alsmentioning

confidence: 99%

Mechanisms by which metals promote events connected to neurodegenerative diseases

Campbell

Smith

Sayre

et al. 2001

Brain Research Bulletin

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Although the exact causative phenomenon responsible for the onset and progression of neurodegenerative disorders is at present unresolved, there are some clues as to the mechanisms underlying these chronic diseases. This review addresses mechanisms by which endogenous or environmental factors, through interaction with redox active metals, may initiate a common cascade of events terminating in neurodegeneration.

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Essential trace element alterations in amyotrophic lateral sclerosis

Cited by 58 publications

References 22 publications

Atomic Absorption Spectroscopy: Fundamentals and Applications in Medicine

Atomic Absorption Spectroscopy: Fundamentals and Applications in Medicine

Implementation of X-ray Fluorescence Microscopy for Investigation of Elemental Abnormalities in Amyotrophic Lateral Sclerosis

Mechanisms by which metals promote events connected to neurodegenerative diseases

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