Essential tremor cured by infarction adjacent to the thalamus.

Duncan, Robert B.; Bone, Ian; Melville, Ian D.

doi:10.1136/jnnp.51.4.591

Cited by 35 publications

(22 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 7 cases, there was improvement or disappearance of tremor following thalamic stroke [45, 48, 73, 78, 82, 86, 98]. Bilateral tremor was reported in 2 cases.…”

Section: Resultsmentioning

confidence: 99%

Post-Thalamic Stroke Movement Disorders: A Systematic Review

Gupta

Pandey²

2018

Eur Neurol

View full text Add to dashboard Cite

Background: After a stroke, movement disorders are rare manifestations mainly affecting the deep structures of the brain like the basal ganglia (44%) and thalamus (37%), although there have been case studies of movement disorders in strokes affecting the cerebral cortex also. Summary: This review aims to delineate the various movement disorders seen in association with thalamic strokes and tries to identify the location of the nuclei affected in each of the described movement disorders. Cases were identified through a search of PubMed database using different search terms related to post-thalamic stroke movement disorders and a secondary search of references of identified articles. We reviewed 2,520 research articles and only 86 papers met the inclusion criteria. Cases were included if they met criteria for post-thalamic stroke movement disorders. Case-cohort studies were also reviewed and will be discussed further. Key Messages: The most common post-stroke abnormal movement disorder reported in our review was dystonia followed by hemiataxia. There was a higher association between ischaemic stroke and movement disorder. Acute onset movement disorders were more common than delayed. The posterolateral thalamus was most commonly involved in post-thalamic stroke movement disorders.

show abstract

“…In 7 cases, there was improvement or disappearance of tremor following thalamic stroke [45, 48, 73, 78, 82, 86, 98]. Bilateral tremor was reported in 2 cases.…”

Section: Resultsmentioning

confidence: 99%

Post-Thalamic Stroke Movement Disorders: A Systematic Review

Gupta

Pandey²

2018

Eur Neurol

View full text Add to dashboard Cite

show abstract

“…Animal studies with the agent harmaline and lesions targeting the dentatorubroolivary tract cause 4-to 8-Hz tremor and, thus, support the pivotal role of the cerebellum in tremor generation (30). Clinical case studies showed that lesions involving the cerebellum (31) or the thalamus (32) can effectively alleviate tremor in essential tremor patients. The ventral intermediate nucleus is the most effective target for stereotactic interventions in tremor control, and rhythmic overactivity correlated with tremor profiles has been identified in the ventral intermediate thalamus in essentialtremor patients undergoing thalamotomy (33).…”

Section: Discussionmentioning

confidence: 99%

GABAergic Dysfunction in Essential Tremor: An¹¹C-Flumazenil PET Study

Boecker¹,

Weindl²,

Brooks³

et al. 2010

J Nucl Med

123

View full text Add to dashboard Cite

“…the olivocerebellar circuit. The most convincing clinical evidence is probably the observation that ET disappears after lesions of the cerebellum, 18 the pons, 19,20 or the thalamus 21 ; locations which are all part of the cerebrocerebello-cerebral loop. Positron emission tomography (PET) studies have shown that there is cerebellar hyperactivity in ET, although it is not yet clear whether this is the cause or the result of tremor in ET.…”

mentioning

confidence: 99%

Pathophysiology of nonparkinsonian tremors

2002

View full text Add to dashboard Cite

Patients with nonparkinsonian tremors are the second largest group treated with functional neurosurgery. We summarize the present pathophysiological knowledge of these conditions. Essential tremor (ET) may be due to oscillations within the olivocerebellar circuit. There is experimental evidence from animal models for such a mechanism, and clinical data indicate an abnormal function of the cerebellum in ET. Cerebellar tremor may be closely related to the tremor seen in advanced ET. The malfunction of the cerebellum causes a pathological feed-forward control. Additionally an oscillator within the cerebellum or its input/output pathways may cause cerebellar tremor. Almost nothing is known about the pathophysiology of dystonic tremor. Holmes tremor is based on a nigral and a cerebellar malfunction and presents clinically as the combination of tremor in Parkinson's disease and cerebellar tremor. Neuropathic tremor can be extremely disabling and is thought to be due to an abnormal interaction of the disturbances within the periphery and abnormal cerebellar feedback. Unlike the case of Parkinson's disease, functional neurosurgery of nonparkinsonian tremors is not yet based on a solid pathophysiological background.

show abstract

Essential tremor cured by infarction adjacent to the thalamus.

Cited by 35 publications

References 6 publications

Post-Thalamic Stroke Movement Disorders: A Systematic Review

Post-Thalamic Stroke Movement Disorders: A Systematic Review

GABAergic Dysfunction in Essential Tremor: An¹¹C-Flumazenil PET Study

Pathophysiology of nonparkinsonian tremors

Contact Info

Product

Resources

About

Essential tremor cured by infarction adjacent to the thalamus.

Cited by 35 publications

References 6 publications

Post-Thalamic Stroke Movement Disorders: A Systematic Review

Post-Thalamic Stroke Movement Disorders: A Systematic Review

GABAergic Dysfunction in Essential Tremor: An11C-Flumazenil PET Study

Pathophysiology of nonparkinsonian tremors

Contact Info

Product

Resources

About

GABAergic Dysfunction in Essential Tremor: An¹¹C-Flumazenil PET Study