Essential value of cocaine and food in rats: tests of the exponential model of demand

Christensen, Chesley J.; Silberberg, Alan; Hursh, Steven R.; Huntsberry, Mary E.; Riley, Anthony L.

doi:10.1007/s00213-008-1120-0

Cited by 70 publications

(101 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This preference shift occurred regardless of the dose of cocaine available and even following a long history of extended access to cocaine self-administration Cantin et al 2010). These findings are generally consistent with previous research (Carroll et al 1989;Carroll and Lac 1993) and with recent behavioral economics studies showing that food (or sucrose) demand was more inelastic than cocaine demand (Christensen et al 2008; Koffarnus and Woods 2011; for review, see Kearns et al 2011). They are also congruent with a recent study showing that mice preferred drinking sucrose over direct optostimulation of midbrain dopamine neurons (Domingos et al 2011).…”

Section: Drug Preference Over Nondrug Rewardssupporting

confidence: 89%

Animal Studies of Addictive Behavior

Vanderschuren

Ahmed

2012

Cold Spring Harbor Perspectives in Medicine

View full text Add to dashboard Cite

It is increasingly recognized that studying drug taking in laboratory animals does not equate to studying genuine addiction, characterized by loss of control over drug use. This has inspired recent work aimed at capturing genuine addiction-like behavior in animals. In this work, we summarize empirical evidence for the occurrence of several DSM-IV-like symptoms of addiction in animals after extended drug use. These symptoms include escalation of drug use, neurocognitive deficits, resistance to extinction, increased motivation for drugs, preference for drugs over nondrug rewards, and resistance to punishment. The fact that addiction-like behavior can occur and be studied in animals gives us the exciting opportunity to investigate the neural and genetic background of drug addiction, which we hope will ultimately lead to the development of more effective treatments for this devastating disorder.

show abstract

Section: Drug Preference Over Nondrug Rewardssupporting

confidence: 89%

Animal Studies of Addictive Behavior

Vanderschuren

Ahmed

2012

Cold Spring Harbor Perspectives in Medicine

View full text Add to dashboard Cite

show abstract

“…The exponential model accounted for >90% of the variance in consumption data. This compares well with between-session procedures where the model has been used (Christensen et al, 2008). Bentzley et al (2013) recently developed a within-session demand procedure where price is manipulated by varying reinforcer magnitude (i.e., dose), rather than reinforcer cost (i.e., FR).…”

Section: Discussionsupporting

confidence: 60%

“…A secondary goal was to evaluate the viability of a within-session demand curve procedure. In previous studies (e.g., Christensen et al, 2008), the FR was manipulated across blocks of sessions, necessitating a large amount of training to obtain a demand curve. The ability to generate a demand curve within a single session could accelerate the pace of data collection.…”

Section: Introductionmentioning

confidence: 99%

Dose and elasticity of demand for self-administered cocaine in rats

Kearns

Silberberg²

2016

Behavioural Pharmacology

Self Cite

View full text Add to dashboard Cite

The present experiment tested whether the elasticity of demand for self-administered cocaine in rats is dose-dependent. Subjects lever pressed for three different doses of intravenous cocaine – 0.11, 0.33, and 1.0 mg/kg/infusion – on a demand procedure where the number of lever presses required per infusion increased within a session. The main finding was that demand for the 0.11 mg/kg dose was more elastic than it was for the two larger doses. There was no difference in demand elasticity between the 0.33 and 1.0 mg/kg doses. These results parallel findings previously reported in monkeys. The present study also demonstrated that a within-session procedure can be used to generate reliable demand curves.

show abstract

“…The demand procedure used here was similar to that in Christensen et al (2008a). Rats were first trained to lever press for cocaine and for food on a fixed-ratio (FR) 1 schedule.…”

Section: Methodsmentioning

confidence: 99%

“…Because EV is not affected by scalar properties of the reinforcer in this way, it is thought to be a purer measure or reinforcer value. A growing number of recent studies have used the exponential demand model to quantify reinforcer value (e.g., Bentzley et al 2013, 2014; Christensen et al 2008a, 2008b; Koffarnus & Woods, 2013; Lamb & Daws, 2013; Schwartz et al 2016). …”

Section: Introductionmentioning

confidence: 99%

Essential values of cocaine and non‐drug alternatives predict the choice between them

et al. 2016

Self Cite

View full text Add to dashboard Cite

This study investigated the relationship between reinforcer value and choice between cocaine and two non-drug alternative reinforcers in rats. The essential value (a behavioral economic measure based on elasticity of demand) of intravenous cocaine and food (Experiment 1) or saccharin (Experiment 2) was determined in the first phase of each experiment. Food had higher essential value than cocaine, whereas the essential values of cocaine and saccharin did not differ. In the second phase of each experiment, rats were allowed to make mutually exclusive choices between cocaine and the non-drug alternative reinforcer. The main findings were that the essential value of cocaine was a positive predictor of cocaine preference and the essential value of food or saccharin was a negative predictor of cocaine preference. An analysis of within-session patterns of choice behavior revealed sequential dependencies, whereby rats were more likely to choose cocaine on a particular trial after having chosen the non-drug alternative on previous trials. When the time between choices was increased, these sequential dependencies disappeared. The results of these experiments are consistent with the suggestion that addiction-like behavior involves both overvaluation of drug reinforcers and undervaluation of non-drug reinforcers.

show abstract

Essential value of cocaine and food in rats: tests of the exponential model of demand

Abstract: The exponential model of demand accommodated the data variance for all cocaine and food demand curves. Compared to food, cocaine is a good of lower essential value.

Cited by 70 publications

References 32 publications

Animal Studies of Addictive Behavior

Animal Studies of Addictive Behavior

Dose and elasticity of demand for self-administered cocaine in rats

Essential values of cocaine and non‐drug alternatives predict the choice between them

Contact Info

Product

Resources

About