? Essentiality of hub proteins in protein-protein interaction networks of yeast

Ryu, Jea Woon; 이윤경,; 강태호,; Yoo, Jae-Soo; 정진수,; 박별나,; Kim, Hee Young; 여명호,

doi:10.3938/jkps.56.1527

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2024

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“…These hub proteins are physiologically more important and evolutionarily more conserved than the non-hub proteins in a PPI network. Although the relationship between a hub protein's biological significance and the degree of interaction is unclear, previous research has concluded that proteins with more than five, eight or twelve links can be identified as hub proteins [ 47 ].…”

Section: Datasetmentioning

confidence: 99%

Determining human-coronavirus protein-protein interaction using machine intelligence

Chakraborty¹,

Mitra²,

Bhattacharjee³

et al. 2023

Medicine in Novel Technology and Devices

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Section: Datasetmentioning

confidence: 99%

Determining human-coronavirus protein-protein interaction using machine intelligence

Chakraborty¹,

Mitra²,

Bhattacharjee³

et al. 2023

Medicine in Novel Technology and Devices

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In silico elucidation of protein-protein interaction network in fish pathogen Flavobacterium Columnare

Nematiasgarabad,

Hashim,

Yahya

2024

MAB

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Flavobacterium columnare is a virulent intracellular bacterial pathogen that causes an infection known as columnaris in many species of fish. Some economically important fish species are strongly affected by columnaris, leading to a high mortality rate and significant economic losses. Previous in silico studies have provided various biological insights into F. columnare, including its interaction with MHC class I alleles and the epitopic region within outer membrane proteins. However, the protein-protein interaction networks underlying the growth, defense, and pathogenesis of F. columnare remain largely unknown. This study was conducted to identify the protein-protein interaction (PPI) networks and hub proteins of F. columnare that can be used as drug or vaccine targets. A total of 500 protein sequences were retrieved from UniprotKB in FASTA format and analyzed using VaxiJen, PSORTb, STRING, Cytoscape, and BLASTp programs. The results demonstrated that 60% of F. columnare proteins were predicted as antigenic proteins, most of which were associated with catalytic activity and metabolic processes, identified as cytoplasmic proteins. Ten hub proteins with the highest number of functional interactions were identified, which were also antigenic and non-host homologous. In conclusion, F. columnare hub proteins represent potential therapeutic targets in drug and vaccine development against columnaris infection.

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? Essentiality of hub proteins in protein-protein interaction networks of yeast

Cited by 2 publications

References 0 publications

Determining human-coronavirus protein-protein interaction using machine intelligence

Determining human-coronavirus protein-protein interaction using machine intelligence

In silico elucidation of protein-protein interaction network in fish pathogen Flavobacterium Columnare

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