Essentials in pressure monitoring blood and other fluids

Cywinski, Jozef K.; Tardieu, Bernard; Heiß, H. W.

doi:10.1002/clc.4960050807

Cited by 20 publications

(21 citation statements)

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“…Mean arterial pressure was calculated as systolic plus doubled diastolic divided by 3. 13 Initially, sample size calculations were not estimated, because the difference found between the 2 groups on stored samples was very evident. On hindsight, power analysis of the P-IPG data from 27 versus 47 samples indicated that the power was 1.00 with a type I error rate (␣) of 0.05 and a population SD of 10.…”

Section: Discussionmentioning

confidence: 99%

Inositol Phosphoglycan P-Type in Preeclampsia

et al. 2007

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Abstract-A state of insulin resistance has been demonstrated in active preeclampsia, and women with clinical evidence of insulin resistance are at higher risk to develop this syndrome during pregnancy. Recently, inositol phosphoglycan P-type, a putative second messenger of insulin action, has been implicated in the pathophysiology of preeclampsia and is increased in the placenta, amniotic fluid, and maternal urine of preeclamptic women compared with normal pregnant women. We report here a case-control study to assess the potential of urinary levels of inositol phosphoglycan P-type as a screening test for preeclampsia. Twenty-seven preeclamptic women and 47 healthy pregnant women were recruited. A polyclonal antibody-based ELISA was developed to detect levels of inositol phosphoglycan P-type in urine. Its content in urinary specimens was found to be 30-fold higher in preeclamptic subjects than control subjects (329.1Ϯ21.8 versus 9.2Ϯ1.5; PϽ0.001), with a higher level in all of the preeclamptic cases. For 6 women who developed preeclampsia, Ͼ1 gestational date sample of urine was available, and retrospective analysis showed a significant time-related increase of the urinary level of inositol phosphoglycan P-type Յ7 weeks before clinical diagnosis of preeclampsia. Urinary level of inositol phosphoglycan P-type increased after diagnosis indicating a possible pathophysiological threshold level and steeply decreased after delivery. Key Words: preeclampsia Ⅲ screening test Ⅲ inositol phosphoglycan Ⅲ biological marker Ⅲ insulin resistance P reeclampsia (PE) represents the most severe form of hypertensive disorder of human pregnancy being associated with a substantial maternal and perinatal morbidity and mortality. 1 It affects Ϸ5% of all pregnancies, although its causes remain unclear. A state of insulin resistance has been demonstrated in active PE, 2,3 and women with clinical evidence of insulin resistance are at higher risk of developing this syndrome during pregnancy. 4 Recently, a family of putative insulin mediators, inositol phosphoglycans (IPGs), have been implicated in the pathophysiology of PE. A high concentration of bioactive IPG P-type (P-IPG) was found in human preeclamptic placenta, 5 urine, and amniotic fluid. 6 Further studies have provided evidence of insulin resistance in human placentas from preeclamptic pregnancies and demonstrated an association between P-IPG and the insulin signaling cascade. 7 IPGs have been demonstrated to exert insulin-mimetic activity in both glucose and lipid metabolism mainly through the activation of pyruvate dehydrogenase phosphatase, glycogen synthase phosphatase, and glycerol-3-phosphate acyltransferase. 8,9 The elevated concentration of glycogen in terminal villi from preeclamptic placentas, because of an increased activity of glycogen synthase, 10 may be a consequence of the abnormal content of P-IPG in the placentas of preeclamptic patients.In this report, we focus our attention on the urinary excretion of IPGs using a novel assay specifically developed to analyze uri...

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Section: Discussionmentioning

confidence: 99%

Inositol Phosphoglycan P-Type in Preeclampsia

et al. 2007

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“…Furthermore, total peripheral resistance, a measure of net constriction versus dilation in the arterial system, was calculated using the formula: (mean arterial pressure x 80 / cardiac output) [25]. Mean arterial pressure was calculated using the formula: [(2 x diastolic blood pressure) + systolic blood pressure / 3] [26]. Cardiac output and total peripheral resistance were used to differentiate challenge and threat states; with a challenge state characterized by higher cardiac output and lower total peripheral resistance [15].…”

Section: Stressmentioning

confidence: 99%

Robotically assisted laparoscopy benefits surgical performance under stress

et al. 2015

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“…MAP was calculated for each epoch with the following equation: MAP = DBP ? 1/3 (SBP -DBP) (Cywinski 1980).…”

Section: Mean Arterial Pressurementioning

confidence: 99%

The role of the menstrual cycle phase in pain perception before and after an isometric fatiguing contraction

et al. 2009

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The purpose of this study was to compare exercise-induced analgesia in young women after a fatiguing isometric contraction during different phases of the menstrual cycle. Twenty female subjects performed a submaximal (25% maximal voluntary contraction) isometric contraction until task failure during both the mid-follicular and mid-luteal phases of their menstrual cycle. Pain perception (i.e., pain threshold and pain ratings) was measured before and after the isometric fatiguing contraction. Other measures included mean arterial pressure, heart rate, and anxiety levels. Time to task failure of the fatiguing contraction was similar for the two phases of the menstrual cycle. Following the performance of the isometric contraction: (1) pain thresholds increased and pain ratings decreased; (2) anxiety levels increased; and (3) mean arterial pressure and heart rate increased. These changes were not dependent on the phase of the menstrual cycle. Thus, the menstrual cycle phase does not influence the magnitude of exercise-induced analgesia.

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Essentials in pressure monitoring blood and other fluids

Abstract: subsw;~-t-d~iii~-~ion,

Cited by 20 publications

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Inositol Phosphoglycan P-Type in Preeclampsia

Inositol Phosphoglycan P-Type in Preeclampsia

Robotically assisted laparoscopy benefits surgical performance under stress

The role of the menstrual cycle phase in pain perception before and after an isometric fatiguing contraction

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